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Protective Effect of Alginate Extraction of Brown Algae on MicroRNAs in Type 1 Diabetes of Rats | ||
| International Journal of Nutrition Sciences | ||
| مقاله 9، دوره 9، شماره 4، اسفند 2024، صفحه 318-324 اصل مقاله (498.48 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2024.102136.1314 | ||
| نویسندگان | ||
| Mohammad Sharifzadeh1؛ Aghil Esmaeili-Bandboni2؛ Mohammadreza Emami1؛ Abbas Mirshafiey* 3، 4؛ Mohammad Hassan Javanbakht* 5 | ||
| 1Department of Clinical Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Medical Biotechnology, School of Paramedical Science, Guilan University of Medical Sciences, Rasht, Iran | ||
| 3Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Livonian Biotech Millennium, Riga, LV-1013, Latvia | ||
| 5Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: MicroRNAs expressions that are known as Posttranscriptional repressors of gene expression in animals and plants have an important role in diabetic consequences and pathogenesis. This research aimed to investigate the expression of miR-34a, miR-126, and miR-125a-5p levels for diagnosis of diabetes, and the effect of α-L-guluronic acid and β-D-mannuronic acid supplementation on expression patterns of these MicroRNAs in diabetic rats. Methods: Total MicroRNAs levels were measured by Quantitative reverse transcription polymerase chain reaction (qRT-PCR) method. Body weight, fasting insulin level, food intake and Vitamin D level in four groups were also assessed after 4 weeks. Results: The analyses illustrate marked declines in expression of miR-126 (p=0.009) and miR-125a-5p (p=0.019) levels in the control diabetic group when compared to the control healthy group. Expression levels of miR-126 (p=0.026) and miR-125a-5p (p=0.041) were upregulated considerably in diabetic rats after treatment with β-D-mannuronic acid and α-L-guluronic acid, respectively. Conclusion: These results suggest that use of miR-126 and 125a-5p is a sensible criterion for diagnosing diabetes. β-D-mannuronic acid is also considered a new therapeutic agent to correct disturbances in the MicroRNAs profile of diabetic rats. | ||
تازه های تحقیق | ||
Mohammad Sharifzadeh (Google Scholar) Abbas Mirshafiey (Google Scholar) Mohammad Hassan Javanbakht (Google Scholar) | ||
| کلیدواژه‌ها | ||
| MicroRNAs؛ Diabetes؛ α-L-guluronic acid؛ β-D-mannuronic acid؛ Rat | ||
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آمار تعداد مشاهده مقاله: 568 تعداد دریافت فایل اصل مقاله: 124 |
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