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Effect of L-carnitine Supplementation on Pro- and Anti-Inflammatory Responses and Blood Pressure Changes Following Resistance Exercise in Non-Athletic Overweight Young Men | ||
| International Journal of Nutrition Sciences | ||
| مقاله 5، دوره 9، شماره 4، اسفند 2024، صفحه 281-290 اصل مقاله (961.77 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2024.102272.1321 | ||
| نویسندگان | ||
| Mehdi Hakimi* 1؛ Maryam Alimohammadi1؛ Hadi Roukhandeh1؛ Stefan Kolimechkov2 | ||
| 1Department of Physical Education and Sport Science, Marivan Branch, Islamic Azad University, Marivan, Iran | ||
| 2Independent Registered Scientist, STK Sport, London, United Kingdom | ||
| چکیده | ||
| Background: Amongst different therapeutic interventions, exercise can improve and control inflammatory and non-inflammatory diseases. This study investigated the effect of L-carnitine supplementation on serum levels of interleukin-8 (IL-8), IL-4, tumour necrosis factor-alpha (TNFα), nitric oxide (NO), and blood pressure after resistance exercise in young men. Methods: Twenty male volunteers were selected by targeted sampling, and were randomly divided into an experimental (L-carnitine supplement) and a control (placebo) groups. The subjects participated in a session of resistance exercise after taking 2 g/day of L-carnitine or a placebo for two weeks. Blood pressure was measured and blood samples after fasting were obtained in four stages of baseline, pre-exercise, immediately, and 24 hours post-exercise. Results: Consumption of L-carnitine could significantly increase serum levels of L-carnitine, IL-4 levels and decrease IL-8 and TNFα levels in the experimental group in comparison to the control group. In the control group, a significant decrease in IL-4 level and an increase in TNFα level were observed. NO and IL-8 increased significantly in both groups immediately after exercise, and then decreased significantly in both groups 24 hours post-exercise. There were significant differences in IL-4, TNFα, and IL-8 levels between the groups at pre-exercise, immediately and 24 h post-exercise in favor of the experimental group, while no significant changes were seen in blood pressure between the groups. Conclusion: It is likely that 2 weeks of L-carnitine supplementation may prevent the increase of inflammation caused by acute resistance exercise. | ||
تازه های تحقیق | ||
Mehdi Hakimi (Google Scholar) | ||
| کلیدواژه‌ها | ||
| L-carnitine؛ Resistance exercise؛ Inflammation؛ Blood pressure؛ Men | ||
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آمار تعداد مشاهده مقاله: 589 تعداد دریافت فایل اصل مقاله: 162 |
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