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The Effect of High-Dose Vitamin D on Inflammatory Markers of ICU Patients with COVID-19 | ||
| International Journal of Nutrition Sciences | ||
| مقاله 2، دوره 9، شماره 4، اسفند 2024، صفحه 260-268 اصل مقاله (555.81 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2024.102550.1320 | ||
| نویسندگان | ||
| Mohammad Hossein Zamanian1؛ Zohreh Javadfar* 2، 3؛ Shima Moradi3، 4؛ Roghayeh Mostafaei3، 4؛ Ali Soroush5؛ Sahar Cheshmeh6؛ Akram Rahimi* 2 | ||
| 1Department of Infectious Diseases, School of Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 2Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 3Department of Nutrition Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 4Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 5Department of Sports Medicine, Cardiovascular Research Center, Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 6Department of Molecular and Experimental Nutritional Medicine, University of Potsdam, Nuthetal, Germany | ||
| چکیده | ||
| Background: Vitamin D can inhibit hyper-inflammatory responses, and there are mechanistic reasons for vitamin D’s beneficial effects in COVID-19 patients. The aim of the present study was to assess how a single high dose of vitamin D can affect inflammatory markers among COVID-19 patients in critical conditions. Methods: A single center, double-blind, randomized clinical trial was conducted on 61 COVID-19 patients admitted to the intensive care units (ICUs). The intervention group received 300,000 IU vitamin D intramuscularly and identically placebo patients were monitored for one week. The levels of lactate dehydrogenase (LDH, IU/mL), C-reactive protein (CRP, mg/L), interleukin-6 (IL-6, Pg/L), lymphocytes, neutrophils, and neutrophil/lymphocyte (N/L) ratios were measured at the start and end of the study. Results: This trial included 44 patients with COVID-19 who had vitamin D deficiency at the start. After a high vitamin D dose intervention, lymphocyte level increased while LDH (IU/mL) and neutrophil levels, and N/L ratio decreased. CRP (mg/L) and IL-6 (Pg/L) levels significantly declined following intervention with a high-dose vitamin D. Conclusion: These findings suggest that high doses of vitamin D may improve inflammatory indices in COVID-19 ICU patients. | ||
تازه های تحقیق | ||
Mohammad Hossein Zamanian (Google Scholar) Zohreh Javadfar (Google Scholar) Akram Rahimi (Google Scholar) | ||
| کلیدواژه‌ها | ||
| Vitamin D؛ 25(OH)D؛ C-reactive protein Interleukin-6؛ COVID-19؛ Iran | ||
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