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The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats | ||
| International Journal of Nutrition Sciences | ||
| مقاله 8، دوره 6، شماره 3، آذر 2021، صفحه 155-160 اصل مقاله (1.36 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2021.92067.1145 | ||
| نویسندگان | ||
| Damilola Ifeoluwa Alawode1؛ Jerome Ndudi Asiwe* 1، 2؛ Emuesiri Goodies Moke3؛ David Ehikhuemen Okonofua1؛ Kamaldeen Olalekan Sanusi1؛ Ebunoluwa Oluwabusola Adagbada1؛ Mariam Onono Yusuf1؛ Adesoji Adedipe Fasanmade1 | ||
| 1Cardiorespiratory Research Unit, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria | ||
| 2Department of Physiology, PAMO University of Medical Sciences, Port-Harcourt, Nigeria | ||
| 3Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria | ||
| چکیده | ||
| Background: Cnidoscolus aconitifolius is widely used by traditional healers in treating plethora of ailments either alone, in combination with other therapeutic agents or as addictive to food/drinks. This study investigated the effect of different doses of C. aconitifolius on cardiorenal function in both normotensive and hypertensive male Wistar rats. Methods: Forty-two male Wistar rats (120-150 g) were categorized into two normotensive and hypertensive groups. Normotensive was group 1 receiving food and water; while normotensive groups 2 and 3 received food and water together with 200 mg and 800 mg of C. aconitifolius for 4 weeks. The hypertensive group 1 received only high salt diet (HSD) and water and hypertensive groups 2 and 3 received HSD and water together with 200 mg and 800 mg of C. aconitifolius, respectively for 4 weeks after confirmation of hypertension. The animals were sacrifice by cervical dislocation and blood sample was collected, and serum was decanted for assays; while heart and kidney were harvested for histological investigation. Results: There were significant reductions in systolic, diastolic and mean arterial blood pressure in hypertensive animals; while was not different in normotensive animals. Urine creatinine and fractional excretion decreased; while the histomorphology of the heart in hypertensive animals showed restorative and regenerative effects of C. aconitifolius. Conclusion: This study suggests that C. aconitifolius potentiates cardiorenal functions by affecting the functional markers, as well as histology. | ||
| کلیدواژه‌ها | ||
| Cnidosculus aconitifolius؛ Cardiorenal؛ Hypertension؛ Creatinine؛ Rat | ||
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