LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,415,570
تعداد دریافت فایل اصل مقاله11,291,389
Zamani, M, Etebari, M, Moradi, Sh. (1399). The Increment of Genoprotective Effect of Melatonin due to “Autooptic” Effect versus the Genotoxicity of Mitoxantrone. سامانه مدیریت نشریات علمی, 10(6), 771-782. doi: 10.31661/jbpe.v0i0.508
M Zamani; M Etebari; Sh Moradi. "The Increment of Genoprotective Effect of Melatonin due to “Autooptic” Effect versus the Genotoxicity of Mitoxantrone". سامانه مدیریت نشریات علمی, 10, 6, 1399, 771-782. doi: 10.31661/jbpe.v0i0.508
Zamani, M, Etebari, M, Moradi, Sh. (1399). 'The Increment of Genoprotective Effect of Melatonin due to “Autooptic” Effect versus the Genotoxicity of Mitoxantrone', سامانه مدیریت نشریات علمی, 10(6), pp. 771-782. doi: 10.31661/jbpe.v0i0.508
Zamani, M, Etebari, M, Moradi, Sh. The Increment of Genoprotective Effect of Melatonin due to “Autooptic” Effect versus the Genotoxicity of Mitoxantrone. سامانه مدیریت نشریات علمی, 1399; 10(6): 771-782. doi: 10.31661/jbpe.v0i0.508

The Increment of Genoprotective Effect of Melatonin due to “Autooptic” Effect versus the Genotoxicity of Mitoxantrone

Journal of Biomedical Physics and Engineering
مقاله 57، دوره 10، شماره 6، اسفند 2020، صفحه 771-782    اصل مقاله (1008.94 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.508
نویسندگان
M Zamani* 1؛ M Etebari2؛ Sh Moradi1
1MSc, Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2PhD, Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Mitoxantrone is a chemotherapy anti-cancer drug, which can have side effects on healthy cells like secondary cancers. On the other side, Melatonin is a hormone that is responsible for the daily rhythm adjustment and has several properties to be anticancer and anti-inflammatory. Recently, it has been shown that all living cells produce ultraweak photon emission (UPE) spontaneously and continuously. The intensity of UPE is in the order of a few, up to 104 photon/(cm2 sec) (or 10−19 to 10−14 W/cm2) measurable by photodetectors. UPEs are produced from diverse natural oxidative and biochemical reactions, especially free radical reactions and the simple cessation of excited molecules. Also, it has been evidenced that UPE has a signaling role at a distance among different cell cultures.
Objective: Here, we investigate the effect of UPE among similar cells (i.e. “Autooptic effect”) by using mirrors around the cell plate(s).
Material and Methods: In this experimental research, the HepG2 cells were co-treated by melatonin as a genoprotective and silver nanoparticles as a carrier against mitoxantrone’s genotoxicity. Our results are analyzed based on the Comet assay method, and the genoprotective effect of melatonin is investigated in presence of (and without) mirrors against the genotoxicity of mitoxantrone. Additionally, the autooptic effect is investigated in presence of Ag nanoparticles (NPs).
Results: The results indicated that Ag NPs with lower concentrations of melatonin made more protection as genoprotective agent, and the same results obtained by increasing access’ cells to drug.
Conclusion: The autooptic effect could increase the genoprotective effect of melatonin.
کلیدواژه‌ها
Genoprotective Effect؛ Melatonin؛ Genotoxicity؛ Mitoxantrone؛ Biophoton؛ Autooptic Effect؛ Free Radicals
سایر فایل های مرتبط با مقاله
مراجع
  1. Alberts DS, Peng YM, Bowden GT, Dalton WS, Mackel C. Pharmacology of mitoxantrone: mode of action and pharmacokinetics. Investigational New Drugs. 1985;3(2):101-7.
  2. Dogra S, Awasthi P, Nair M, Barthwal R. Interaction of anticancer drug mitoxantrone with DNA hexamer sequence d-(CTCGAG)2 by absorption, fluorescence and circular dichroism spectroscopy. J Photochem Photobiol B. 2013;123:48-54. doi: 10.1016/j.jphotobiol.2013.03.015. PubMed PMID: 23624101.
  3. Mishra S, Mishra RP. A comparison of the in vitro Genotoxicity of Anticancer Drugs Melphalan and Mitoxantrone. American Journal of Biomedical Sciences. 2013;5(3). doi: 10.5099/aj130300171.
  4. Blanz J, Mewes K, Ehninger G, Proksch B, Waidelich D, Greger B, et al. Evidence for oxidative activation of mitoxantrone in human, pig, and rat. Drug Metab Dispos. 1991;19:871-80. PubMed PMID: 1686230.
  5. Buschini A, Poli P, Rossi C. Saccharomyces cerevisiae as an eukaryotic cell model to assess cytotoxicity and genotoxicity of three anticancer anthraquinones. Mutagenesis. 2003;18:25-36. doi: 10.1093/mutage/18.1.25. PubMed PMID: 12473732.
  6. Ferguson LR, Denny WA. Genotoxicity of non-covalent interactions: DNA intercalators. Mutat Res. 2007;623:14-23. doi: 10.1016/j.mrfmmm.2007.03.014. PubMed PMID: 17498749.
  7. Kolodziejczyk P, Reszka K, Lown JW. Enzymatic oxidative activation and transformation of the antitumor agent mitoxantrone. Free Radic Biol Med. 1988;5:13-25. doi: 10.1016/0891-5849(88)90058-5. PubMed PMID: 3254299.
  8. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51:1-16. doi: 10.1111/j.1600-079X.2011.00916.x. PubMed PMID: 21752095.
  9. Sliwinski T, Rozej W, Morawiec-Bajda A, Morawiec Z, Reiter R, Blasiak J. Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair. Mutat Res. 2007;634:220-7. doi: 10.1016/j.mrgentox.2007.07.013. PubMed PMID: 17851115.
  10. Hardeland R. Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. The Scientific World Journal. 2012;2012:1-18. doi: 10.1100/2012/640389.
  11. Motilva V, Garcia-Maurino S, Talero E, Illanes M. New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin. J Pineal Res. 2011;51:44-60. doi: 10.1111/j.1600-079X.2011.00915.x. PubMed PMID: 21752096.
  12. Ferreira SG, Peliciari-Garcia RA, Takahashi-Hyodo SA, Rodrigues AC, Amaral FG, Berra CM, et al. Effects of melatonin on DNA damage induced by cyclophosphamide in rats. Braz J Med Biol Res. 2013;46:278-86. doi: 10.1590/1414-431X20122230. PubMed PMID: 23471360. PubMed PMCID: 3854377.
  13. Tozan-Beceren A. Melatonin protects against acrylamideinduced oxidative tissue damage in rats. Marmara Pharmaceutical Journal. 2012 ;3(16):213-21. doi: 10.12991/201216401.
  14. Cifra M, Fields JZ, Farhadi A. Electromagnetic cellular interactions. Progress in biophysics and molecular biology. 2011;105(3):223-46. doi: 10.1016/j.pbiomolbio.2010.07.003.
  15. Salari V, Tuszynski J, Bokkon I, Rahnama M, Cifra M. On the photonic cellular interaction and the electric activity of neurons in the human brain. Journal of Physics: Conference Series. 2011;329:(1). doi: 10.1088/1742-6596/329/1/012006.
  16. Gurwitsch A. Physikalisches über mitogenetische Strahlen. Development Genes and Evolution. 1924;103:490-8. doi: 10.1007/bf02107498.
  17. Cifra M, Pospisil P. Ultra-weak photon emission from biological samples: definition, mechanisms, properties, detection and applications. J Photochem Photobiol B. 2014;139:2-10. doi: 10.1016/j.jphotobiol.2014.02.009. PubMed PMID: 24726298.
  18. Petrash VV, Borovkov EI, Dovgusha VV, Ivanova VA, Egorov YN, Il’ina LV, editors. Autooptic Effect. Doklady Biochemistry and Biophysics. 2004;396:174-6. doi: 10.1023/B:DOBI.0000033522.90775.95.
  19. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen. 2000;35:206-21. doi: 10.1002/(SICI)1098-2280(2000)35:33.0.CO;2-J. PubMed PMID: 10737956.
  20. Devaraj B, Scott R, Roschger P, Inaba H. Ultraweak light emission from rat liver nuclei. Photochemistry and photobiology. 1991;54:289-93. doi: 10.1111/j.1751-1097.1991.tb02018.x.
  21. Prasad PN. Introduction to biophotonics. John Wiley & Sons; 2004.
  22. Nakano M. Low-level chemiluminescence during lipid peroxidations and enzymatic reactions. J Biolumin Chemilumin. 1989;4:231-40. doi: 10.1002/bio.1170040133. PubMed PMID: 2801214.
  23. Prasad A, Pospisil P. Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. PLoS One. 2011;6:e22345. doi: 10.1371/journal.pone.0022345. PubMed PMID: 21799835. PubMed PMCID: 3143142.
  24. Stoyanova II, Gulubova MV. Mast cells and inflammatory mediators in chronic ulcerative colitis. Acta Histochem. 2002;104:185-92. doi: 10.1078/0065-1281-00641. PubMed PMID: 12086339.
  25. Hackenberg S, Scherzed A, Kessler M, Hummel S, Technau A, Froelich K, et al. Silver nanoparticles: evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells. Toxicol Lett. 2011;201:27-33. doi: 10.1016/j.toxlet.2010.12.001. PubMed PMID: 21145381.
  26. Pospisil P, Prasad A, Rac M. Role of reactive oxygen species in ultra-weak photon emission in biological systems. J Photochem Photobiol B. 2014;139:11-23. doi: 10.1016/j.jphotobiol.2014.02.008. PubMed PMID: 24674863.
  27. Ahn JM, Eom HJ, Yang X, Meyer JN, Choi J. Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, caenorhabditis elegans. Chemosphere. 2014;108:343-52. doi: 10.1016/j.chemosphere.2014.01.078. PubMed PMID: 24726479.
  28. Etebari M, Ghannadi A, Jafarian-Dehkordi A, Ahmadi F. Genotoxicity evaluation of aqueous extracts of co-toneaster discolor and Alhagi pseudalhagi by com-et assay. Journal of Research in Medical Sciences. 2012;17.
  29. Etebari M, Zolfaghari B, Jafarian-Dehkordi A, Rakian R. Evaluation of DNA damage of hydro-alcoholic and aqueous extract of Echium amoenum and Nardostachys jatamansi. J Res Med Sci. 2012;17:782-6. PubMed PMID: 23798947. PubMed PMCID: 3687887.
  30. Tavakoli M, Bateni E, Rismanchian M, Fathi M, Doostmohammadi A, Rabiei A, et al. Genotoxicity effects of nano bioactive glass and Novabone bioglass on gingival fibroblasts using single cell gel electrophoresis (comet assay): An in vitro study. Dent Res J (Isfahan). 2012;9:314-20. PubMed PMID: 23087738. PubMed PMCID: 3469899.
  31. Park MV, Neigh AM, Vermeulen JP, De La Fonteyne LJ, Verharen HW, Briede JJ, et al. The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles. Biomaterials. 2011;32:9810-7. doi: 10.1016/j.biomaterials.2011.08.085. PubMed PMID: 21944826.
  32. McShan D, Ray PC, Yu H. Molecular toxicity mechanism of nanosilver. J Food Drug Anal. 2014;22:116-27. doi: 10.1016/j.jfda.2014.01.010. PubMed PMID: 24673909. PubMed PMCID: 4281024.
  33. Poljaková J, Eckschlager T, Hraběta J, Hřebačková J, Smutný S, Frei E, Martínek V, Kizek R, Stiborová M. The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells. Biochemical Pharmacology. 2009;77(9):1466-79. doi: 10.1016/j.bcp.2009.01.021.
  34. Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013;65(2):157-70. doi: 10.1111/j.2042-7158.2012.01567.x.
  35. Kizek R, Adam V, Hrabeta J, Eckschlager T, Smutny S, Burda JV, Frei E, Stiborova M. Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances. Pharmacology & Therapeutics. 2012;133(1):26-39. doi:10.1016/j.pharmthera.2011.07.006.
  36. Ferreira SG, Peliciari-Garcia RA, Takahashi-Hyodo SA, Rodrigues AC, Amaral FG, Berra CM, Bordin S, Curi R, Cipolla-Neto J. Effects of melatonin on DNA damage induced by cyclophosphamide in rats. Braz J Med Biol Res. 2013;46(3):278-86. doi: 10.1590/1414-431X20122230. PubMed PMID: 23471360. PubMed PMCID: PMC3854377.
  37. Ma D, Tremblay P, Mahngar K, Akbari-Asl P, Pandey S, Collins J, Hudlicky T. Induction of apoptosis and autophagy in human pancreatic cancer cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin. Am J Biomed Sci. 2011;3(4):278-91. doi: 10.5099/aj110400278.
  38. Carli PM, Sgro C, Parchin-Geneste N, Isambert N, Mugneret F, Girodon F, Maynadie M. Increase therapy-related leukemia secondary to breast cancer. Leukemia. 2000;14(6):1014-7. doi: 10.1038/sj.leu.2401787. PubMed PMID: 10865966.
  39. Franke SI, Prá D, Erdtmann B, Henriques JA, Da Silva J. Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis. Mutagenesis. 2005;20(4):279-83. doi: 10.1093/mutage/gei034. PubMed PMID: 15956044.
  40. Jamil K, Shaik AP. Pesticide induced cytogenetic risk assessment in human lymphocyte culture in vitro. Bull Environ Contam Toxicol. 2005;75(1):7-14. doi: 10.1007/s00128-005-0711-2. PubMed PMID: 16228866.
  41. Le Deley MC, Suzan F, Cutuli B, Delaloge S, Shamsaldin A, Linassier C, Clisant S, De Vathaire F, Fenaux P, Hill C. Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer. Journal of clinical oncology. 2007;25(3):292-300. doi: 10.1200/JCO.2006.05.9048.
  42. Rivero MT, Vázquez-Gundın F, Goyanes V, Campos A, Blasco M, Gosálvez J, Fernández JL. High frequency of constitutive alkali-labile sites in mouse major satellite DNA, detected by DNA breakage detection-fluorescence in situ hybridization. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2001;483(1-2):43-50. doi: 10.1016/s0027-5107(01)00218-4 PubMed PMID: 11600131.
  43. Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L, Livrea MA. The chemistry of melatonin’s interaction with reactive species. Journal of Pineal Research. 2003;34(1):1-0. doi: 10.1034/j.1600-079X.2003.02112.x.
  44. Hardeland R, Balzer I, Poeggeler B, Fuhrberg B, Una H, Behrmann G, Wolf R, Meyer TJ, Reiter RJ. On the primary functions of melatonin in evolution: mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals. Journal of Pineal Research. 1995;18(2):104-11. doi: 10.1111/j.1600-079X.1995.tb00147.x.
  45. Salari V, Valian H, Bassereh H, Bókkon I, Barkhordari A. Ultraweak photon emission in the brain. Journal of integrative neuroscience. 2015;14(03):419-29. doi: 10.1142/S0219635215300012.
آمار
تعداد مشاهده مقاله: 1,727
تعداد دریافت فایل اصل مقاله: 392


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب