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Ghaffarpasand, Fariborz, Shahrezaei, Mostafa, Dehghankhalili, Maryam. (1395). Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial. سامانه مدیریت نشریات علمی, 4(Issue 3), 134-140.
Fariborz Ghaffarpasand; Mostafa Shahrezaei; Maryam Dehghankhalili. "Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial". سامانه مدیریت نشریات علمی, 4, Issue 3, 1395, 134-140.
Ghaffarpasand, Fariborz, Shahrezaei, Mostafa, Dehghankhalili, Maryam. (1395). 'Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial', سامانه مدیریت نشریات علمی, 4(Issue 3), pp. 134-140.
Ghaffarpasand, Fariborz, Shahrezaei, Mostafa, Dehghankhalili, Maryam. Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial. سامانه مدیریت نشریات علمی, 1395; 4(Issue 3): 134-140.

Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial

Bulletin of Emergency And Trauma
مقاله 5، دوره 4، Issue 3، مهر 2016، صفحه 134-140    اصل مقاله (642.91 K)
نویسندگان
Fariborz Ghaffarpasand1؛ Mostafa Shahrezaei2؛ Maryam Dehghankhalili* 1
1Shiraz University of Medical Sciences
2AJA University of Medical Sciences
چکیده
Objective: To determine the effects of platelet rich plasma PRP on healing rates of long bone non-union fracture.Method: This was a randomized double-blind placebo controlled clinical trial being performed in a 12-month period. We included 75 adult (>18 years) patients suffering from long bone (Femur, Tibia, Humerus and Ulna) non-union fracture who were randomly assigned to receive 5mL PRP (n=37) or 5mL normal saline as placebo (n=38) in the site of fracture after intramedullary nailing or open reduction and internal fixation (ORIF) along with autologous bone graft. Patients were followed each 45 days till 9 months and were evaluated both clinically and radiologically in each visit. The healing rate, failure rate, incidence of infection, mal-union and limb shortening were recorded and compared between groups after 9 months of follow-up.Results: The healing rate was significantly higher in PRP group compared to placebo (81.1% vs. 55.3%; p=0.025). The limb shortening was significantly higher in those who received placebo (2.61±1.5 vs. 1.88±1.2mm; p=0.030). Injection of PRP was also associated with lower pain scores (p=0.003) and shorter healing duration (p=0.046). The surgical site infection (p=0.262) and mal-union rate (p=0.736) were comparable between groups.Conclusion: Application of PRP along with autologous bone graft in the site of non-union of long bone after intramedullary nailing or ORIF results in higher cure rate, shorter healing duration, lower limb shortening and less postoperative pain. Higher infection rate might be a complication of PRP application.Keywords: Non-union; Long bone Fracture; Platelet rich plasma (PRP); Intramedullary nailing; Open reduction and internal fixation (ORIF).Clinical Trial Registry: This trial is registered with the Iranian Clinical Trials Registry (IRCT201208262445N1; www.irct.ir).
کلیدواژه‌ها
Non-union؛ Long bone fracture؛ Platelet rich plasma (PRP)؛ Intramedullary nailing؛ Open reduction and internal fixation (ORIF)
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