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Biosensing Based on Surface-Enhanced Raman Spectroscopy by Using Metal Nanoparticles | ||
| Journal of Biomedical Physics and Engineering | ||
| مقاله 6، دوره 2، شماره 2، شهریور 2012 اصل مقاله (933.06 K) | ||
| نوع مقاله: Review Article | ||
| نویسندگان | ||
| M. Saliminasab* 1؛ A. R. Bahrampour2؛ M. H. Zandi3 | ||
| 1Master of Science Student, Photonic Department, Kerman Graduate University of Technology, Kerman, Iran | ||
| 2Professor of Physics, Department of Physics, Sharif University of Technology, Tehran, Iran | ||
| 3Assistant Professor of Physics, Department of Physics, Shahid Bahonar University of Kerman, Kerman, Iran | ||
| چکیده | ||
| Surface-enhanced Raman spectroscopy (SERS) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. This technique consists of locating the target analyte on nanometer range of roughed Au-nanoparticles. The presence of the metal nanoparticles provides a tremendous enhancement to the resulting Raman signal through an electromagnetic enhancement of both the laser excitation light and stokes-shifted light by 5–6 orders of magnitudes. SERS makes it possible to create a spectroscopic device that can act as a highly sensitive molecular detector using Raman signal as a fingerprint of the analyte. In this review, we present a general overview of the recent advancements in SERS as an analytical tool for identification of molecular species with concentrations below biological level in aqueous solution, with a particular attention to its potential applications in biomedicine. | ||
| کلیدواژهها | ||
| Analytes؛ Nanoparticles؛ Biosensor؛ Raman spectroscopy؛ Surface plasmon resonance | ||
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آمار تعداد مشاهده مقاله: 682 تعداد دریافت فایل اصل مقاله: 202 |
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