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Erfani, Nasrollah, Haghshenas, Mohammad Reza, Hoseini, Mohammad Ali, Hashemi, Seyed Basi, Khademi, Bijan, Ghaderi, Abbas. (1391). Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer. سامانه مدیریت نشریات علمی, 9(3), 188-198.
Nasrollah Erfani; Mohammad Reza Haghshenas; Mohammad Ali Hoseini; Seyed Basi Hashemi; Bijan Khademi; Abbas Ghaderi. "Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer". سامانه مدیریت نشریات علمی, 9, 3, 1391, 188-198.
Erfani, Nasrollah, Haghshenas, Mohammad Reza, Hoseini, Mohammad Ali, Hashemi, Seyed Basi, Khademi, Bijan, Ghaderi, Abbas. (1391). 'Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer', سامانه مدیریت نشریات علمی, 9(3), pp. 188-198.
Erfani, Nasrollah, Haghshenas, Mohammad Reza, Hoseini, Mohammad Ali, Hashemi, Seyed Basi, Khademi, Bijan, Ghaderi, Abbas. Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer. سامانه مدیریت نشریات علمی, 1391; 9(3): 188-198.

Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer

Iranian Journal of Immunology
مقاله 5، دوره 9، شماره 3، آذر 2012، صفحه 188-198    اصل مقاله (435.47 K)
نوع مقاله: Original Article
نویسندگان
Nasrollah Erfani1؛ Mohammad Reza Haghshenas1؛ Mohammad Ali Hoseini2؛ Seyed Basi Hashemi2؛ Bijan Khademi2؛ Abbas Ghaderi* 1
1Cancer Immunology Group, Shiraz Institute for Cancer Research
2Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Variations in Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) affect the expression and function of this protein.
Objective: We aimed to investigate the association of +49 A/G (rs231775), +1822 C/T (rs231779) and +6230 A/G (CT60, rs3087243) genetic variations, as well as the merged haplotypes in CTLA-4 gene with susceptibility to, or progression of head and neck cancer.
Methods: Eighty patients with confirmed head and neck (HN) cancer (age 54.9 ± 16.1 years) and 85 healthy age/sexmatched controls (age 56.3 ± 12.4 years) were enrolled in the study. Genotypes were investigated by the PCR-RFLP method. Arlequin software package was used to check for Hardy-Weinberg equilibration, and to estimate the haplotypes.
Results: At position +6230 A/G (CT60), AA genotype, as well as A allele was significantly decreased in patients with HN cancers than controls (18.8% vs. 40.7%, p=0.004; odds ratio=0.34, and 46.3% vs. 61.7, p=0.007; odds ratio=0.53%, respectively). Nearly the same results were obtained when we compared the subgroup of patients with squamous cell carcinoma of the HN (SCC-HN) with control subjects. The frequencies of genotypes and alleles at other positions were not significantly different between patients and controls, however ACG, GTA and GCA haplotypes emerged from three investigated loci occurred with significantly more frequencies in patients (p<0.0001), while ACA and GTG haplotypes were more frequent among controls (p<0.0001). Significant differences of haplotypes, genotypes and alleles frequencies resisted the Bonferroni correction.
Conclusion: Our results suggest that CT60 A allele, as well as ACA and GTG haplotypes in CTLA-4 gene may have protective roles against HN cancer in Iranian population, while ACG, GTA and specially GCA haplotypes may render susceptibility.
کلیدواژه‌ها
Genetic Marker؛ ctla-4؛ Haplotype؛ Head and Neck Cancer؛ Polymorphism؛ Squamous cell carcinoma
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