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Sereshki, Nasrin, Alipour, Razieh, Rezaei, Nahid, Rezaei, Abbas, Naseri, Mohsen, Ghasemi, Fahimeh, Hosseini, Seyedeh Sindokht, Rafiee, Mitra. (1405). Progesterone-induced Blocking Factor Increases the Frequency of Foxp3+CD4+CD25+ Regulatory T Cells in Human Peripheral Blood. سامانه مدیریت نشریات علمی, 23(3), 2-2. doi: 10.22034/iji.2026.109060.3124
Nasrin Sereshki; Razieh Alipour; Nahid Rezaei; Abbas Rezaei; Mohsen Naseri; Fahimeh Ghasemi; Seyedeh Sindokht Hosseini; Mitra Rafiee. "Progesterone-induced Blocking Factor Increases the Frequency of Foxp3+CD4+CD25+ Regulatory T Cells in Human Peripheral Blood". سامانه مدیریت نشریات علمی, 23, 3, 1405, 2-2. doi: 10.22034/iji.2026.109060.3124
Sereshki, Nasrin, Alipour, Razieh, Rezaei, Nahid, Rezaei, Abbas, Naseri, Mohsen, Ghasemi, Fahimeh, Hosseini, Seyedeh Sindokht, Rafiee, Mitra. (1405). 'Progesterone-induced Blocking Factor Increases the Frequency of Foxp3+CD4+CD25+ Regulatory T Cells in Human Peripheral Blood', سامانه مدیریت نشریات علمی, 23(3), pp. 2-2. doi: 10.22034/iji.2026.109060.3124
Sereshki, Nasrin, Alipour, Razieh, Rezaei, Nahid, Rezaei, Abbas, Naseri, Mohsen, Ghasemi, Fahimeh, Hosseini, Seyedeh Sindokht, Rafiee, Mitra. Progesterone-induced Blocking Factor Increases the Frequency of Foxp3+CD4+CD25+ Regulatory T Cells in Human Peripheral Blood. سامانه مدیریت نشریات علمی, 1405; 23(3): 2-2. doi: 10.22034/iji.2026.109060.3124

Progesterone-induced Blocking Factor Increases the Frequency of Foxp3+CD4+CD25+ Regulatory T Cells in Human Peripheral Blood

Iranian Journal of Immunology
دوره 23، شماره 3، آذر 2026، صفحه 2-2
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22034/iji.2026.109060.3124
نویسندگان
Nasrin Sereshki1؛ Razieh Alipour1؛ Nahid Rezaei2؛ Abbas Rezaei3؛ Mohsen Naseri4؛ Fahimeh Ghasemi5؛ Seyedeh Sindokht Hosseini6؛ Mitra Rafiee* 7
1Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2Department of Immunology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
3Department of Immunology, School of Medicine, Immunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
4Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
5Pharmaceutical Sciences Research Center, Birjand University of Medical Sciences, Birjand, Iran.
6Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
7Department of Immunology, School of Medicine, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
چکیده
Background: Pregnancy is a unique immunological state in which the semi-allogeneic fetus must be tolerated by the maternal immune system. Progesterone-induced blocking factor (PIBF) contributes to sustaining this immune balance through its regulatory effects, particularly those involving CD25⁺ T cells and maternal immune tolerance mechanisms.
Objective: To investigate whether PIBF influences the proportion of Foxp3+ cells among activated human peripheral CD4+ CD25+ T cells. 
Materials and methods: We isolated peripheral blood mononuclear cells (PBMCs) were isolated from 15 healthy women of reproductive-age, all sampled during the follicular phase of their menstrual cycles. The cells were stimulated with anti-CD3, anti-CD28 and IL-2 and cultured for 5 days in the presence or absence of PIBF at concentrations of 200 or 1000 ng/mL. The proportion of CD4+CD25+Foxp3+T cells was quantified by flow cytometry.
Results: Treatment with PIBF increased the percentage of CD4+CD25+Foxp3+ T cells compared with untreated controls (mean ± SE: control 2.7 ± 1.18%; PIBF 200 ng/mL 3.05 ± 1.06%, p = 0.008; PIBF 1000 ng/mL 3.50 ± 1.39%, p = 0.002). Although the increases were significant relative to the control group, no clear dose‑dependent trend was observed between the two PIBF concentrations. No adverse effects on cell viability were detected under the experimental conditions.
Conclusion: In vitro treatment of activated human peripheral CD4+CD25+ T cells with PIBF increased the percentage of Foxp3+ cells, suggesting that PIBF may promote regulatory T cell phenotypes in the context of maternal–fetal tolerance.
کلیدواژه‌ها
Fetal-maternal tolerance؛ Forkhead box P3 (Foxp3)؛ Progesterone-induced blocking factor؛ Regulatory T cells
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تعداد مشاهده مقاله: 7


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