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Al- Mayyahi, Zainab, Abdul Reda, Entissar Abdul Latif, Shanan Jaber, Abd Ali. (1404). Comparison of Monthly and Weekly Doses of Cholecalciferol in Treatment of Perimenopausal Women with Vitamin D Deficiency. سامانه مدیریت نشریات علمی, 11(1), 108-114. doi: 10.30476/ijns.2026.106223.1432
Zainab Al- Mayyahi; Entissar Abdul Latif Abdul Reda; Abd Ali Shanan Jaber. "Comparison of Monthly and Weekly Doses of Cholecalciferol in Treatment of Perimenopausal Women with Vitamin D Deficiency". سامانه مدیریت نشریات علمی, 11, 1, 1404, 108-114. doi: 10.30476/ijns.2026.106223.1432
Al- Mayyahi, Zainab, Abdul Reda, Entissar Abdul Latif, Shanan Jaber, Abd Ali. (1404). 'Comparison of Monthly and Weekly Doses of Cholecalciferol in Treatment of Perimenopausal Women with Vitamin D Deficiency', سامانه مدیریت نشریات علمی, 11(1), pp. 108-114. doi: 10.30476/ijns.2026.106223.1432
Al- Mayyahi, Zainab, Abdul Reda, Entissar Abdul Latif, Shanan Jaber, Abd Ali. Comparison of Monthly and Weekly Doses of Cholecalciferol in Treatment of Perimenopausal Women with Vitamin D Deficiency. سامانه مدیریت نشریات علمی, 1404; 11(1): 108-114. doi: 10.30476/ijns.2026.106223.1432

Comparison of Monthly and Weekly Doses of Cholecalciferol in Treatment of Perimenopausal Women with Vitamin D Deficiency

International Journal of Nutrition Sciences
مقاله 11، دوره 11، شماره 1، خرداد 2026، صفحه 108-114    اصل مقاله (516.77 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.106223.1432
نویسندگان
Zainab Al- Mayyahi* 1؛ Entissar Abdul Latif Abdul Reda2؛ Abd Ali Shanan Jaber3
1Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq
2Department of Biochemistry, College of Medicine, University of Basrah, Basrah, Iraq
3Department of Medicine, Al-Basrah Teaching Hospital, Basrah, Iraq
چکیده
Background: Women in their perimenopausal period should have an optimal vitamin D level. This study compared monthly versus weekly doses of cholecalciferol in treatment of perimenopausal women with vitamin D deficiency.
Methods: Eighty 42-57 years old women with vitamin D deficiency were enrolled. Half of the patients received bolus monthly oral doses and the other half of patients received weekly oral doses for four months. The vitamin D level was determined at the end of each month and one month after the end of the period of treatment. Demographic and biochemical
data were analyzed too.
Results: Demographic information indicated absence of any significant difference between the two treatment groups. Serum level of 25(OH)D3 in the monthly group ranged from 11.5±2.6 ng/mL to 48.6±4.8 ng/mL from baseline to day 111, whereas those in the weekly group ranged from 10.3±3.1 ng/mL to 46.9±6.3 ng/mL. On days 27, 55, 83, 111, and 150, there was no discernible difference in the fluctuations of 25(OH) D3 level between the two treatment groups; while the mean change from baseline between the two groups only became significant on day 13. Between baseline and day 150, no significant alteration happened for biochemical markers.
Conclusion: Weekly and monthly vitamin D dosages were equally effective in restoring normal level of 25(OH) D3 in perimenopausal women with vitamin D deficiency.

تازه های تحقیق

Zainab A Al-Mayyahi (Google Scholar)

کلیدواژه‌ها
Vitamin D؛ Cholecalciferol؛ 25(OH) D3؛ Deficiency؛ Perimenopausal women
مراجع
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