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Khatapoush, Saba, Mohit, Mohsen, Mansouri Shirazi, Fatemeh, Moazen, Mahsa, Ebrahimzadeh, Armin, Hejazi, Najmeh. (1404). The Effect of Vitamin K Supplementation on Glycemic Indices in Adults: A Systematic Review and Meta- Analysis of Clinical Trials. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2025.103594.1336
Saba Khatapoush; Mohsen Mohit; Fatemeh Mansouri Shirazi; Mahsa Moazen; Armin Ebrahimzadeh; Najmeh Hejazi. "The Effect of Vitamin K Supplementation on Glycemic Indices in Adults: A Systematic Review and Meta- Analysis of Clinical Trials". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijns.2025.103594.1336
Khatapoush, Saba, Mohit, Mohsen, Mansouri Shirazi, Fatemeh, Moazen, Mahsa, Ebrahimzadeh, Armin, Hejazi, Najmeh. (1404). 'The Effect of Vitamin K Supplementation on Glycemic Indices in Adults: A Systematic Review and Meta- Analysis of Clinical Trials', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2025.103594.1336
Khatapoush, Saba, Mohit, Mohsen, Mansouri Shirazi, Fatemeh, Moazen, Mahsa, Ebrahimzadeh, Armin, Hejazi, Najmeh. The Effect of Vitamin K Supplementation on Glycemic Indices in Adults: A Systematic Review and Meta- Analysis of Clinical Trials. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijns.2025.103594.1336

The Effect of Vitamin K Supplementation on Glycemic Indices in Adults: A Systematic Review and Meta- Analysis of Clinical Trials

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 اردیبهشت 1404    اصل مقاله (1.42 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijns.2025.103594.1336
نویسندگان
Saba Khatapoush1؛ Mohsen Mohit1؛ Fatemeh Mansouri Shirazi1؛ Mahsa Moazen2؛ Armin Ebrahimzadeh1؛ Najmeh Hejazi* 2
1Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Vitamin K supplementation was shown to be effective on glucose hemostasis and insulin sensitivity in some previous studies, but the results are controversial. The purpose of this meta-analysis was to investigate the effect of vitamin K supplementation on glycemic indices including fasting blood sugar (FBS), hemoglobin A1c (HbA1c), fasting insulin (FI), homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI) and homeostasis model assessment of β-cell function (HOMA-β).
Methods: The systematic search of literatures was performed on electronic databases of PubMed, Scopus, and Web of Science databases up to December, 2024. The weighted mean difference (WMD) and 95% confidence intervals (95% CI) were calculated to evaluate the pooled effect size using the random-effect model. The heterogeneity was evaluated using I-square (I2) statistics. Subgroup analysis was done to evaluate the potential sources of heterogeneity.
Results: Among all of the eligible studies, six randomized clinical trials (RCTs) were included in this meta-analysis. The results showed a significant effect of vitamin K supplementation on some glycemic indices including FI (WMD: -1.87; 95% CI: -2.64, -1.09), HbA1c (WMD: -0.89; 95% CI: -1.40, -0.38) and HOMA-IR (WMD: -0.35; 95% CI: -0.39, -0.31).
Also, the effect of vitamin K supplementation on other glycemic indices including FBS (WMD: -4.74; 95% CI: -10.56, 1.09), HOMA-β (WMD: -0.36; 95% CI: -1.44, 0.73) were not a significant effect.
Conclusion: The findings of this study indicated that vitamin K supplementation can positively affect FI, HbA1c, and HOMA-IR levels.

تازه های تحقیق

Najmeh Hejazi (Google Scholar)

کلیدواژه‌ها
Vitamin K؛ Glycemic indices؛ Fasting blood sugar؛ Insulin؛ Adult
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