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Pouryousef, Ali, Omidian, Mostafa, Asadzadeh, Seyed Ali, Morovatti, Hamid, Zomorodian, Kamyar, Sarkari, Bahador. (1403). Efficacy of Azole Derivatives, Clotrimazole, Itraconazole, and Voriconazole on Cystic Echinococcosis protoscolices: A Comparative Study. سامانه مدیریت نشریات علمی, 11(1), 51-58. doi: 10.30476/tips.2025.105577.1280
Ali Pouryousef; Mostafa Omidian; Seyed Ali Asadzadeh; Hamid Morovatti; Kamyar Zomorodian; Bahador Sarkari. "Efficacy of Azole Derivatives, Clotrimazole, Itraconazole, and Voriconazole on Cystic Echinococcosis protoscolices: A Comparative Study". سامانه مدیریت نشریات علمی, 11, 1, 1403, 51-58. doi: 10.30476/tips.2025.105577.1280
Pouryousef, Ali, Omidian, Mostafa, Asadzadeh, Seyed Ali, Morovatti, Hamid, Zomorodian, Kamyar, Sarkari, Bahador. (1403). 'Efficacy of Azole Derivatives, Clotrimazole, Itraconazole, and Voriconazole on Cystic Echinococcosis protoscolices: A Comparative Study', سامانه مدیریت نشریات علمی, 11(1), pp. 51-58. doi: 10.30476/tips.2025.105577.1280
Pouryousef, Ali, Omidian, Mostafa, Asadzadeh, Seyed Ali, Morovatti, Hamid, Zomorodian, Kamyar, Sarkari, Bahador. Efficacy of Azole Derivatives, Clotrimazole, Itraconazole, and Voriconazole on Cystic Echinococcosis protoscolices: A Comparative Study. سامانه مدیریت نشریات علمی, 1403; 11(1): 51-58. doi: 10.30476/tips.2025.105577.1280

Efficacy of Azole Derivatives, Clotrimazole, Itraconazole, and Voriconazole on Cystic Echinococcosis protoscolices: A Comparative Study

Trends in Pharmaceutical Sciences
مقاله 5، دوره 11، شماره 1، خرداد 2025، صفحه 51-58    اصل مقاله (406.43 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.105577.1280
نویسندگان
Ali Pouryousef1؛ Mostafa Omidian2؛ Seyed Ali Asadzadeh2؛ Hamid Morovatti2؛ Kamyar Zomorodian3؛ Bahador Sarkari* 2، 4
1Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
2Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Cystic echinococcosis (CE) presents significant public health challenges in various regions worldwide. The adverse effects and limited efficacy of current scolicidal agents, underscore the urgent need for novel therapeutics developments. This study aimed to evaluate the scolicidal effects of the azole compounds clotrimazole, itraconazole, and voriconazole on CE protoscolices. Protoscolices were aseptically harvested from ovine hepatic hydatid cysts. After confirming high viability (over 90%) through eosin staining, the protoscolices were subjected to graded concentrations of clotrimazole, itraconazole, and voriconazole. A 20% saline solution served as the positive control, while a DMSO solution (the drug solvent) used as the negative control. Following a three-hour exposure period, eosin staining and microscopic examination were employed to determine the proportion of viable protoscolices. Statistical analysis was conducted using SPSS software and ANOVA tests. The results showed that the percentage of dead protoscolices in the presence of clotrimazole was significantly higher compared to the negative control and both itraconazole and voriconazole, although it was significantly lower than the positive control. The highest mortality rate in the clotrimazole group was observed at 1024 µg/mL, corresponding to an 89.9±63.69% mortality rate. The data also indicated a statistically significant correlation between increasing clotrimazole concentration and its mortality rate (p=0.011). These findings suggest that clotrimazole exhibits superior scolicidal activity against CE protoscolices compared to itraconazole and voriconazole, indicating its potential as an anti-parasitic medication, suitable for alternative or adjunctive treatment of this debilitating disease.

تازه های تحقیق

Ali Pouryousef (Google Scholar)

Kamyar Zomorodian (Google Scholar)

Bahador Sarkari (Google Scholar)

کلیدواژه‌ها
Hydatid cyst؛ protoscolices؛ azoles؛ clotrimazole؛ itraconazole؛ voriconazole
مراجع
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