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Kashani, Seyed Mohammad Amin, Abdoli, Narges, Khodaei, Forouzan, Honarpishefard, Zahra, Golzar, Tahereh, Dastkhosh, Nazi, Salimi, Azad, Azarpira, Negar, Niknahad, Hossein, Heidari, Reza. (1403). L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction. سامانه مدیریت نشریات علمی, 11(1), 39-50. doi: 10.30476/tips.2025.105274.1279
Seyed Mohammad Amin Kashani; Narges Abdoli; Forouzan Khodaei; Zahra Honarpishefard; Tahereh Golzar; Nazi Dastkhosh; Azad Salimi; Negar Azarpira; Hossein Niknahad; Reza Heidari. "L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction". سامانه مدیریت نشریات علمی, 11, 1, 1403, 39-50. doi: 10.30476/tips.2025.105274.1279
Kashani, Seyed Mohammad Amin, Abdoli, Narges, Khodaei, Forouzan, Honarpishefard, Zahra, Golzar, Tahereh, Dastkhosh, Nazi, Salimi, Azad, Azarpira, Negar, Niknahad, Hossein, Heidari, Reza. (1403). 'L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction', سامانه مدیریت نشریات علمی, 11(1), pp. 39-50. doi: 10.30476/tips.2025.105274.1279
Kashani, Seyed Mohammad Amin, Abdoli, Narges, Khodaei, Forouzan, Honarpishefard, Zahra, Golzar, Tahereh, Dastkhosh, Nazi, Salimi, Azad, Azarpira, Negar, Niknahad, Hossein, Heidari, Reza. L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction. سامانه مدیریت نشریات علمی, 1403; 11(1): 39-50. doi: 10.30476/tips.2025.105274.1279

L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction

Trends in Pharmaceutical Sciences
مقاله 4، دوره 11، شماره 1، خرداد 2025، صفحه 39-50    اصل مقاله (577.45 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.105274.1279
نویسندگان
Seyed Mohammad Amin Kashani1، 2؛ Narges Abdoli3؛ Forouzan Khodaei1؛ Zahra Honarpishefard1، 2؛ Tahereh Golzar1، 2؛ Nazi Dastkhosh1، 2؛ Azad Salimi1، 2؛ Negar Azarpira4؛ Hossein Niknahad1، 5؛ Reza Heidari* 1
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
3Halal Research Center, Iran Food and Drug Administration, Tehran, Iran.
4Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
5Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Acute kidney injury (AKI) is a significant clinical problem associated with high morbidity and mortality. Unilateral ureter obstruction (UUO) is a well-established model for studying the pathophysiology of AKI. L arginine (ARG), a precursor of nitric oxide, has been shown to possess renoprotective properties. This study aims to investigate the protective effects of ARG in an animal model of UUO-induced AKI. Male BALB/c mice were randomly allotted into sham-operated, UUO, and UUO + L-Arginine. UUO was surgically induced by ligating the left ureter. The treatment group received ARG (100, 250, and 500 mg/kg/day) intraperitoneally for seven days post-UUO surgery. Renal function was assessed by measuring plasma creatinine (Cr) and blood urea nitrogen (BUN) levels. Mitochondrial function was evaluated by determining mitochondrial membrane potential, dehydrogenases activity, and mitochondrial swelling. Oxidative stress markers, including ROS formation, lipid peroxidation, protein carbonylation, and tissue antioxidant capacity, were also measured in the kidney tissue. UUO led to significant renal dysfunction, as evidenced by increased serum Cr and BUN levels (P<0.001). Mitochondrial dysfunction was indicated by decreased mitochondrial dehydrogenase activity, mitochondrial depolarization, and increased mitochondrial swelling (P<0.001). Additionally, UUO-induced oxidative stress was demonstrated. It was found that ARG treatment significantly improved renal function by modulating mitochondrial function and decreasing oxidative stress markers (P<0.05). These findings suggest that ARG may have therapeutic potential in managing AKI by preserving mitochondrial function and reducing oxidative damage.

تازه های تحقیق

Seyed Mohammad Amin Kashani (Google Scholar)

Narges Abdoli (Google Scholar)

Negar Azarpira (Google Scholar)

Hossein Niknahad (Google Scholar)

Reza Heidari (Google Scholar)

کلیدواژه‌ها
Acute kidney injury؛ Mitochondrial impairment؛ Nephrotoxicity؛ Renal failure
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