پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,187 |
| تعداد مقالات | 10,824 |
| تعداد مشاهده مقاله | 72,833,593 |
| تعداد دریافت فایل اصل مقاله | 12,911,451 |
Soluble HLA-E and Gastroesophageal Reflux Disease: A Novel Association | ||
| Iranian Journal of Immunology | ||
| دوره 22، شماره 1، خرداد 2025، صفحه 83-88 اصل مقاله (624.52 K) | ||
| نوع مقاله: Short Paper | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2025.104717.2915 | ||
| نویسندگان | ||
| Huda Saleem Hantoosh Hameed Al-khalidy1؛ Wafaa Hazim Salih2؛ Batool Mutar Mahdi* 3 | ||
| 1Department of Biochemistry, Al-Kindy Medical College, University of Baghdad, Baghdad, Iraq. | ||
| 2Department of Microbiology, Al-Kindy Medical College, University of Baghdad, Baghdad, Iraq. | ||
| 3HLA Research Unit, Al-Kindy Medical College, University of Baghdad, Baghdad, Iraq. | ||
| چکیده | ||
| Background: Gastroesophageal reflux disease (GERD) is a prevalent clinical condition that affects millions of individuals worldwide. Aim of the study: To assess the level of soluble HLA-E (sHLA-E) as a biomarker in the diagnosis and immunopathogenesis of GERD patients. Materials and methods: The case-control prospective study included 40 GERD patients who were consulted at the Gastroenterology Unit of Al-Kindy Teaching Hospital, as along with 40 healthy control subjects. The study period extended from January 2023 to May 2024. Blood was drawn from both groups and serum was separated to assesss HLA-E using a sandwich enzyme-linked immunosorbent assay (ELISA) kit. Results: There was a statistically significant difference in sHLA-E levels between GERD patients and healthy controls (p = 0.021). The median sHLA-E level was significantly higher in GERD patients (0.370 ng/mL) compared to controls (0.148 ng/mL). A receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic performance of soluble HLA-E (sHLA-E) in predicting GERD. The area under the ROC curve (AUC) was calculated to assess the discriminatory ability of sHLA-E, with a value of 0.649 (95% CI: 0.534-0.752, p = 0.021). The optimal cutoff value for sHLA-E was determined to be ≤0.65 ng/mL, with a sensitivity of 85.1%, specificity of 27.3%, positive predictive value of 65.9%, negative predictive value of 69.4%, and accuracy of 35.0%. Conclusions: The study provides evidence of an association between elevated sHLA-E levels and GERD. It also suggests that sHLA-E has a moderate discriminatory ability as a biomarker in predicting GERD. | ||
| کلیدواژه‌ها | ||
| Dyspepsia؛ GERD؛ sHLA-E | ||
|
آمار تعداد مشاهده مقاله: 247 تعداد دریافت فایل اصل مقاله: 137 |
||