Restoring Functional Connectivity in Hemiplegic Cerebral Palsy: A Study of Low-Frequency rTMS Intervention | ||
| Journal of Biomedical Physics and Engineering | ||
| دوره 15، شماره 2 - شماره پیاپی 1، تیر 2025، صفحه 173-184 اصل مقاله (1.03 M) | ||
| نوع مقاله: Original Research | ||
| شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2410-1840 | ||
| نویسندگان | ||
| Azadeh Ghalyanchi-Langeroudi1، 2؛ Elahé Yargholi3؛ Maryam Soleimani4؛ Amin Shahrokhi4؛ Mohammad-Mehdi Mirbagheri* 1، 5، 6 | ||
| 1Department of Medical Physics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Research Center for Biomedical Technologies and Robotics (RCBTR), Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran, University of Medical Science (TUMS), Tehran, Iran | ||
| 3Laboratory of Biological Psychology, Department of Brain and Cognition, Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven 3714, Belgium | ||
| 4Department of Basic Science, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran | ||
| 5Neural Engineering and Rehabilitation Research Center, Tehran, Iran | ||
| 6Department of Physical Medicine and Rehabilitation, Northwestern University, USA | ||
| چکیده | ||
| Background: Hemiplegic Cerebral Palsy (HCP) causes significant motor impairments, due to disrupted Functional Connectivity (FC) between brain regions. Low-Frequency Repetitive Transcranial Magnetic Stimulation (LF-rTMS) has emerged as a potential therapeutic technique for restoring FC and motor recovery. Objective: This study aimed to evaluate the effects of LF-rTMS on FC in children with spastic HCP. Material and Methods: This Randomized Controlled Trial (RCT) included ten children with spastic HCP, aged 4 to 13 years. Six children received 12 sessions of LF-rTMS, while four in the control group underwent 12 sessions of sham stimulation. Functional Magnetic Resonance Imaging (fMRI) was used to assess intra- and interhemispheric FC during passive knee movements of the affected limb. Results: LF-rTMS induced region-specific reductions in interhemispheric FC, particularly between the contralesional ventral premotor area (cPMv) and both the ipsilesional primary somatosensory cortex (iS1) (for effect size: T=-2.60, P-value=0.048, FDR-corrected) and the ipsilesional primary motor area (iM1) (T=-2.45, P-value=0.048, FDR-corrected). These findings suggest modulation of interhemispheric motor-sensory pathways. Concurrently, localized increases in FC were observed in contralesional regions, and FC decreased between the ipsilesional Supplementary Motor Area (SMA) and the secondary somatosensory cortex (S2) (T=-3.11, P-value=0.041, FDR-corrected). Conclusion: LF-rTMS may modulate FC and hold promise as a rehabilitative intervention for improving motor function in children with HCP. | ||
تازه های تحقیق | ||
Azadeh Ghalyanchi-Langeroudi (PubMed) Mohammad-Mehdi Mirbagheri (Google Scholar) | ||
| کلیدواژهها | ||
| Cerebral Palsy؛ Transcranial Magnetic Stimulation؛ Functional Connectivity؛ Magnetic Resonance Imaging | ||
| مراجع | ||
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