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Ghalyanchi-Langeroudi, Azadeh, Yargholi, Elahé, Soleimani, Maryam, Shahrokhi, Amin, Mirbagheri, Mohammad-Mehdi. (1404). Restoring Functional Connectivity in Hemiplegic Cerebral Palsy: A Study of Low-Frequency rTMS Intervention. سامانه مدیریت نشریات علمی, 15(2), 173-184. doi: 10.31661/jbpe.v0i0.2410-1840
Azadeh Ghalyanchi-Langeroudi; Elahé Yargholi; Maryam Soleimani; Amin Shahrokhi; Mohammad-Mehdi Mirbagheri. "Restoring Functional Connectivity in Hemiplegic Cerebral Palsy: A Study of Low-Frequency rTMS Intervention". سامانه مدیریت نشریات علمی, 15, 2, 1404, 173-184. doi: 10.31661/jbpe.v0i0.2410-1840
Ghalyanchi-Langeroudi, Azadeh, Yargholi, Elahé, Soleimani, Maryam, Shahrokhi, Amin, Mirbagheri, Mohammad-Mehdi. (1404). 'Restoring Functional Connectivity in Hemiplegic Cerebral Palsy: A Study of Low-Frequency rTMS Intervention', سامانه مدیریت نشریات علمی, 15(2), pp. 173-184. doi: 10.31661/jbpe.v0i0.2410-1840
Ghalyanchi-Langeroudi, Azadeh, Yargholi, Elahé, Soleimani, Maryam, Shahrokhi, Amin, Mirbagheri, Mohammad-Mehdi. Restoring Functional Connectivity in Hemiplegic Cerebral Palsy: A Study of Low-Frequency rTMS Intervention. سامانه مدیریت نشریات علمی, 1404; 15(2): 173-184. doi: 10.31661/jbpe.v0i0.2410-1840

Restoring Functional Connectivity in Hemiplegic Cerebral Palsy: A Study of Low-Frequency rTMS Intervention

Journal of Biomedical Physics and Engineering
دوره 15، شماره 2 - شماره پیاپی 1، تیر 2025، صفحه 173-184    اصل مقاله (1.03 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2410-1840
نویسندگان
Azadeh Ghalyanchi-Langeroudi1، 2؛ Elahé Yargholi3؛ Maryam Soleimani4؛ Amin Shahrokhi4؛ Mohammad-Mehdi Mirbagheri* 1، 5، 6
1Department of Medical Physics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Research Center for Biomedical Technologies and Robotics (RCBTR), Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran, University of Medical Science (TUMS), Tehran, Iran
3Laboratory of Biological Psychology, Department of Brain and Cognition, Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven 3714, Belgium
4Department of Basic Science, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
5Neural Engineering and Rehabilitation Research Center, Tehran, Iran
6Department of Physical Medicine and Rehabilitation, Northwestern University, USA
چکیده
Background: Hemiplegic Cerebral Palsy (HCP) causes significant motor impairments, due to disrupted Functional Connectivity (FC) between brain regions. Low-Frequency Repetitive Transcranial Magnetic Stimulation (LF-rTMS) has emerged as a potential therapeutic technique for restoring FC and motor recovery.
Objective: This study aimed to evaluate the effects of LF-rTMS on FC in children with spastic HCP.
Material and Methods: This Randomized Controlled Trial (RCT) included ten children with spastic HCP, aged 4 to 13 years. Six children received 12 sessions of LF-rTMS, while four in the control group underwent 12 sessions of sham stimulation. Functional Magnetic Resonance Imaging (fMRI) was used to assess intra- and interhemispheric FC during passive knee movements of the affected limb.
Results: LF-rTMS induced region-specific reductions in interhemispheric FC, particularly between the contralesional ventral premotor area (cPMv) and both the ipsilesional primary somatosensory cortex (iS1) (for effect size: T=-2.60, P-value=0.048, FDR-corrected) and the ipsilesional primary motor area (iM1) (T=-2.45, P-value=0.048, FDR-corrected). These findings suggest modulation of interhemispheric motor-sensory pathways. Concurrently, localized increases in FC were observed in contralesional regions, and FC decreased between the ipsilesional Supplementary Motor Area (SMA) and the secondary somatosensory cortex (S2) (T=-3.11, P-value=0.041, FDR-corrected). 
Conclusion: LF-rTMS may modulate FC and hold promise as a rehabilitative intervention for improving motor function in children with HCP.

تازه های تحقیق

Azadeh Ghalyanchi-Langeroudi (PubMed)

Mohammad-Mehdi Mirbagheri (Google Scholar)

کلیدواژه‌ها
Cerebral Palsy؛ Transcranial Magnetic Stimulation؛ Functional Connectivity؛ Magnetic Resonance Imaging
سایر فایل های مرتبط با مقاله
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