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Evaluation of Dendritic Cell Subpopulations Frequency in COVID-19 Patients and their Correlation with Disease Severity | ||
| Iranian Journal of Immunology | ||
| دوره 22، شماره 1، خرداد 2025، صفحه 70-82 اصل مقاله (1.65 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2025.104236.2887 | ||
| نویسندگان | ||
| Vahid Asghariazar1؛ Majid Eterafi2؛ Somaieh Matin3؛ Nasrin Fouladi4، 5؛ Rozita Abolhasani1؛ Monireh Falsafi1؛ Afshin Fathi6؛ Elham Safarzadeh* 1، 7 | ||
| 1Cancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran. | ||
| 2Students Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran. | ||
| 3Department of Internal Medicine, Emam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran. | ||
| 4School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran. | ||
| 5Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran. | ||
| 6Pediatric Hematology and Oncology Department, Ardabil University of Medical Science, Ardabil, Iran. | ||
| 7Department of Microbiology, Parasitology, and Immunology, Ardabil University of Medical Sciences, Ardabil, Iran. | ||
| چکیده | ||
| Background: COVID-19 (2019) clearly demonstrates an imbalanced immune response. Variations in the function and subtypes of dendritic cells (DCs) may have effects on immune responses in COVID-19 patients and contribute to immunopathology. Objectives: To assess the phenotype and frequency of Plasmacytoid dendritic cells (pDCs), Conventional DCs (cDCs), and double-positive DCs in COVID-19 patients admitted to the ICU and non-ICU compared to the healthy control group. Methods: The study included 10 healthy individuals and 25 COVID-19 patients. In the second week of their illness, Peripheral blood mononuclear cells (PBMCs) were isolated from the patients and labeled with targeted antibodies for HLA-DR, CD123, and CD11c. The samples were then analyzed using flow cytometry. The COVID-19 patients were divided into two ICU and non-ICU groups and were closely monitored throughout the study. Results: In comparison to healthy controls, COVID-19 patients exhibited a significantly lower pDCs ratio (P=0.04). Patients were categorized into two groups: (A) the ICU group (n=11; 44%) and (B) the non-ICU group (n=14; 56%). The frequency of pDC was significantly lower in ICU patients than in non-ICU patients (P<0.01). Although not statistically significant, ICU patients had a lower frequency of cDCs and double positive DCs compared to non-ICU patients. Additionally, a significant association between the age of COVID-19 patients and cDC levels was observed (p=0.049). Conclusion: SARS-CoV-2 can evade attacks from the immune response by reducing the number of DCs and suppressing their function of DCs, ultimately resulting in weakened development of both innate and adaptive immunity. | ||
| کلیدواژه‌ها | ||
| CD11c؛ CD123؛ Corona virus؛ Dendritic cells؛ HLA- DR | ||
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