Simulation Study on the Dynamics of Cavitation Bubbles in Multi-Frequency Ultrasound | ||
| Journal of Biomedical Physics and Engineering | ||
| دوره 15، شماره 2 - شماره پیاپی 1، تیر 2025، صفحه 185-198 اصل مقاله (1.39 M) | ||
| نوع مقاله: Original Research | ||
| شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2410-1841 | ||
| نویسندگان | ||
| Hu Dong* 1؛ Gang Liu2؛ Gaofeng Peng1 | ||
| 1School of Information Science and Engineering, Changsha Normal University, Changsha 410100, China | ||
| 2School of Information Science and Engineering, Xinyu University, Xinyu, 338004, China | ||
| چکیده | ||
| Background: High-intensity focused ultrasound (HIFU) therapy is an effective minimally invasive treatment technique. Objective: This work aimed to present a theoretical foundation for transient cavitation control in HIFU treatment and investigate cavitation bubbles in multi-frequency ultrasound. Material and Methods: In this theoretical study, the nonlinear vibrations of bubbles in different mediums (water, urine, kidney, and muscle) were simulated using Gilmore-Akulichev and modified Keller-Miksis equations. The dynamic changes of bubble radius during irradiation by multi-frequency combined ultrasound were analyzed, and the effects of multi-frequency ultrasound combinations and frequency differences on the maximum and minimum values of bubble expansion radius and bubble collapse time were investigated. Results: At the same highest frequency, the triple-frequency produced the largest bubble expansion radius (Rmax) while the single-frequency resulted in the smallest bubble expansion radius (Rmin). At the same lowest frequency, the single-frequency had the biggest bubble expansion radius and the triple-frequency had the smallest bubble expansion radius. Compared to the combination with a large frequency difference at high frequency, the triple-frequency combination with a small frequency difference at low frequency exhibited a noticeably larger Rmax, but Rmin showed the opposite behavior. Rmax/Rmin decreased for the same ultrasonic combination when the medium viscosity increased. The bubble expansion radius ratio Rmax/Rmin was positively correlated with the bubble collapse time. Conclusion: There was a strong correlation between the frequency difference and the multi-frequency ultrasound combination and the maximum and minimum values of the cavitation bubble radius and the collapse time. | ||
تازه های تحقیق | ||
Hu Dong (PubMed) | ||
| کلیدواژهها | ||
| High-Intensity Focused Ultrasound؛ Nonlinear؛ Transient؛ Cavitation؛ Dynamic؛ Collapse؛ Viscosity؛ Ultrasonics؛ Radius | ||
| مراجع | ||
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