LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,174
تعداد مقالات10,723
تعداد مشاهده مقاله66,997,240
تعداد دریافت فایل اصل مقاله12,407,305
Barjasteh, Amir Hossein, AleKassar, Rawa Jaseb Mazhar, Al-Asady, Abdulridha Mohammed, Latifi, Hanieh, Avan, Amir, Khazaei, Majid, Ryzhikov, Mikhail, Hassanian, Seyed Mahdi. (1403). Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2024.102910.3622
Amir Hossein Barjasteh; Rawa Jaseb Mazhar AleKassar; Abdulridha Mohammed Al-Asady; Hanieh Latifi; Amir Avan; Majid Khazaei; Mikhail Ryzhikov; Seyed Mahdi Hassanian. "Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review". سامانه مدیریت نشریات علمی, , , 1403, -. doi: 10.30476/ijms.2024.102910.3622
Barjasteh, Amir Hossein, AleKassar, Rawa Jaseb Mazhar, Al-Asady, Abdulridha Mohammed, Latifi, Hanieh, Avan, Amir, Khazaei, Majid, Ryzhikov, Mikhail, Hassanian, Seyed Mahdi. (1403). 'Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2024.102910.3622
Barjasteh, Amir Hossein, AleKassar, Rawa Jaseb Mazhar, Al-Asady, Abdulridha Mohammed, Latifi, Hanieh, Avan, Amir, Khazaei, Majid, Ryzhikov, Mikhail, Hassanian, Seyed Mahdi. Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review. سامانه مدیریت نشریات علمی, 1403; (): -. doi: 10.30476/ijms.2024.102910.3622

Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 20 اسفند 1403    اصل مقاله (1.8 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2024.102910.3622
نویسندگان
Amir Hossein Barjasteh1؛ Rawa Jaseb Mazhar AleKassar2؛ Abdulridha Mohammed Al-Asady3، 4، 5، 6؛ Hanieh Latifi1؛ Amir Avan6، 7؛ Majid Khazaei6، 8؛ Mikhail Ryzhikov9؛ Seyed Mahdi Hassanian* 2
1Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Medical Sciences, Faculty of Nursing, Warith Al-Anbiyaa University, Iraq
4Department of Medical Sciences, Faculty of Dentistry, University of Kerbala, Iraq
5Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
7Faculty of Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia
8Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
9Saint Louis University, School of Medicine, St. Louis, MO, USA
چکیده
Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide and is the fourth leading cause of cancer-related deaths. Metastasis poses a significant obstacle in CRC treatment, as distant metastasis, particularly to the liver, remains the primary cause of mortality. Colorectal liver metastasis (CRLM) occurs frequently due to the liver’s direct vascular connection to the colorectal region via the portal vein. Standard treatment approaches for CRLM are limited; only a few patients qualify for surgical intervention, resulting in a persistently low survival rate. Additionally, resistance to chemotherapy is common, emphasizing the need for more effective targeted therapies. Emerging evidence highlights the pivotal role of microRNAs (miRNAs) in modulating critical pathways associated with CRLM, including tumor invasion, epithelial-mesenchymal transition, and angiogenesis. MiRNAs exhibit dual functions as tumor suppressors and oncogenes by targeting multiple genes, thus playing a complex role in both the initiation and progression of metastasis. The regulatory mechanisms of miRNAs could help to identify novel biomarkers for early diagnosis and prognosis of CRLM, as well as promising therapeutic targets to overcome chemoresistance. Despite numerous studies on miRNA involvement in CRC metastasis, dedicated reviews focusing on miRNAs and CRLM remain scarce. This review aims to approach targeted therapies by examining the current understanding of miRNA involvement in CRLM and exploring their potential as diagnostic, prognostic, and therapeutic agents. Through an integrative approach, we aim to provide insights that could transform CRLM management and improve patient outcomes.
کلیدواژه‌ها
Colorectal cancer؛ MicroRNAs؛ Liver؛ Metastasis؛ Exosome؛ Therapeutics
مراجع
  1. Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends--An Update. Cancer Epidemiol Biomarkers Prev. 2016;25:16-27. doi: 10.1158/1055-9965.EPI-15-0578. PubMed PMID: 26667886.
  2. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49:33-64. doi: 10.3322/canjclin.49.1.33. PubMed PMID: 10200776.
  3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209-49. doi: 10.3322/caac.21660. PubMed PMID: 33538338.
  4. de Ridder J, de Wilt JH, Simmer F, Overbeek L, Lemmens V, Nagtegaal I. Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients. Oncotarget. 2016;7:55368-76. doi: 10.18632/oncotarget.10552. PubMed PMID: 27421135; PubMed Central PMCID: PMCPMC5342423.
  5. Tauriello DV, Calon A, Lonardo E, Batlle E. Determinants of metastatic competency in colorectal cancer. Mol Oncol. 2017;11:97-119. doi: 10.1002/1878-0261.12018. PubMed PMID: 28085225; PubMed Central PMCID: PMCPMC5423222.
  6. Valderrama-Trevino AI, Barrera-Mera B, Ceballos-Villalva JC, Montalvo-Jave EE. Hepatic Metastasis from Colorectal Cancer. Euroasian J Hepatogastroenterol. 2017;7:166-75. doi: 10.5005/jp-journals-10018-1241. PubMed PMID: 29201802; PubMed Central PMCID: PMCPMC5670263.
  7. Yu X, Zhu L, Liu J, Xie M, Chen J, Li J. Emerging Role of Immunotherapy for Colorectal Cancer with Liver Metastasis. Onco Targets Ther. 2020;13:11645-58. doi: 10.2147/OTT.S271955. PubMed PMID: 33223838; PubMed Central PMCID: PMCPMC7671511.
  8. Al Bandar MH, Kim NK. Current status and future perspectives on treatment of liver metastasis in colorectal cancer (Review). Oncol Rep. 2017;37:2553-64. doi: 10.3892/or.2017.5531. PubMed PMID: 28350137.
  9. Takahashi H, Berber E. Role of thermal ablation in the management of colorectal liver metastasis. Hepatobiliary Surg Nutr. 2020;9:49-58. doi: 10.21037/hbsn.2019.06.08. PubMed PMID: 32140478; PubMed Central PMCID: PMCPMC7026789.
  10. Filoni E, Musci V, Di Rito A, Inchingolo R, Memeo R, Mannavola F. Multimodal Management of Colorectal Liver Metastases: State of the Art. Oncol Rev. 2023;17:11799. doi: 10.3389/or.2023.11799. PubMed PMID: 38239856; PubMed Central PMCID: PMCPMC10794467.
  11. Zhou H, Liu Z, Wang Y, Wen X, Amador EH, Yuan L, et al. Colorectal liver metastasis: molecular mechanism and interventional therapy. Signal Transduct Target Ther. 2022;7:70. doi: 10.1038/s41392-022-00922-2. PubMed PMID: 35246503; PubMed Central PMCID: PMCPMC8897452.
  12. Pan Z, Peng J, Lin J, Chen G, Wu X, Lu Z, et al. Is there a survival benefit from adjuvant chemotherapy for patients with liver oligometastases from colorectal cancer after curative resection? Cancer Commun (Lond). 2018;38:29. doi: 10.1186/s40880-018-0298-8. PubMed PMID: 29843800; PubMed Central PMCID: PMCPMC5993126.
  13. Noren A, Eriksson HG, Olsson LI. Selection for surgery and survival of synchronous colorectal liver metastases; a nationwide study. Eur J Cancer. 2016;53:105-14. doi: 10.1016/j.ejca.2015.10.055. PubMed PMID: 26702764.
  14. Price TJ, Beeke C, Ullah S, Padbury R, Maddern G, Roder D, et al. Does the primary site of colorectal cancer impact outcomes for patients with metastatic disease? Cancer. 2015;121:830-5. doi: 10.1002/cncr.29129. PubMed PMID: 25377235.
  15. Engstrand J, Nilsson H, Stromberg C, Jonas E, Freedman J. Colorectal cancer liver metastases - a population-based study on incidence, management and survival. BMC Cancer. 2018;18:78. doi: 10.1186/s12885-017-3925-x. PubMed PMID: 29334918; PubMed Central PMCID: PMCPMC5769309.
  16. Low EE, Demb J, Liu L, Earles A, Bustamante R, Williams CD, et al. Risk Factors for Early-Onset Colorectal Cancer. Gastroenterology. 2020;159:492-501 e7. doi: 10.1053/j.gastro.2020.01.004. PubMed PMID: 31926997; PubMed Central PMCID: PMCPMC7343609.
  17. Riddiough GE, Fifis T, Muralidharan V, Perini MV, Christophi C. Searching for the link; mechanisms underlying liver regeneration and recurrence of colorectal liver metastasis post partial hepatectomy. J Gastroenterol Hepatol. 2019;34:1276-86. doi: 10.1111/jgh.14644. PubMed PMID: 30828863.
  18. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10-29. doi: 10.3322/caac.20138. PubMed PMID: 22237781.
  19. Margonis GA, Buettner S, Andreatos N, Kim Y, Wagner D, Sasaki K, et al. Association of BRAF Mutations With Survival and Recurrence in Surgically Treated Patients With Metastatic Colorectal Liver Cancer. JAMA Surg. 2018;153:e180996. doi: 10.1001/jamasurg.2018.0996. PubMed PMID: 29799910; PubMed Central PMCID: PMCPMC6137519.
  20. Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, et al. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nat Commun. 2018;9:1793. doi: 10.1038/s41467-018-04278-6. PubMed PMID: 29728604; PubMed Central PMCID: PMCPMC5935683.
  21. Shi R, Chen W, Yang B, Qu J, Cheng Y, Zhu Z, et al. Prediction of KRAS, NRAS and BRAF status in colorectal cancer patients with liver metastasis using a deep artificial neural network based on radiomics and semantic features. Am J Cancer Res. 2020;10:4513-26. PubMed PMID: 33415015; PubMed Central PMCID: PMCPMC7783758.
  22. Tsilimigras DI, Ntanasis-Stathopoulos I, Bagante F, Moris D, Cloyd J, Spartalis E, et al. Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence. Surg Oncol. 2018;27:280-8. doi: 10.1016/j.suronc.2018.05.012. PubMed PMID: 29937183.
  23. Hui L, Chen Y. Tumor microenvironment: Sanctuary of the devil. Cancer Lett. 2015;368:7-13. doi: 10.1016/j.canlet.2015.07.039. PubMed PMID: 26276713.
  24. Vitale I, Manic G, Coussens LM, Kroemer G, Galluzzi L. Macrophages and Metabolism in the Tumor Microenvironment. Cell Metab. 2019;30:36-50. doi: 10.1016/j.cmet.2019.06.001. PubMed PMID: 31269428.
  25. Yang L, Lin PC. Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression. Semin Cancer Biol. 2017;47:185-95. doi: 10.1016/j.semcancer.2017.08.001. PubMed PMID: 28782608; PubMed Central PMCID: PMCPMC5698110.
  26. Mathieu M, Martin-Jaular L, Lavieu G, Thery C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21:9-17. doi: 10.1038/s41556-018-0250-9. PubMed PMID: 30602770.
  27. Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-Mediated Metastasis: Communication from a Distance. Dev Cell. 2019;49:347-60. doi: 10.1016/j.devcel.2019.04.011. PubMed PMID: 31063754.
  28. Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17:302-17. doi: 10.1038/nrc.2017.6. PubMed PMID: 28303905.
  29. Valcz G, Galamb O, Krenacs T, Spisak S, Kalmar A, Patai AV, et al. Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass. Mod Pathol. 2016;29:928-38. doi: 10.1038/modpathol.2016.72. PubMed PMID: 27150162.
  30. Abo-Elela DA, Salem AM, Swellam M, Hegazy MG. Potential diagnostic role of circulating MiRNAs in colorectal cancer. Int J Immunopathol Pharmacol. 2023;37:3946320221144565. doi: 10.1177/03946320221144565. PubMed PMID: 36598779; PubMed Central PMCID: PMCPMC9830083.
  31. Kalluri R. The biology and function of exosomes in cancer. J Clin Invest. 2016;126:1208-15. doi: 10.1172/JCI81135. PubMed PMID: 27035812; PubMed Central PMCID: PMCPMC4811149.
  32. Zeng Z, Li Y, Pan Y, Lan X, Song F, Sun J, et al. Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nat Commun. 2018;9:5395. doi: 10.1038/s41467-018-07810-w. PubMed PMID: 30568162; PubMed Central PMCID: PMCPMC6300604.
  33. Shao Y, Chen T, Zheng X, Yang S, Xu K, Chen X, et al. Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis. Carcinogenesis. 2018;39:1368-79. doi: 10.1093/carcin/bgy115. PubMed PMID: 30184100.
  34. Liu H, Liu Y, Sun P, Leng K, Xu Y, Mei L, et al. Colorectal cancer-derived exosomal miR-106b-3p promotes metastasis by down-regulating DLC-1 expression. Clin Sci (Lond). 2020;134:419-34. doi: 10.1042/CS20191087. PubMed PMID: 32065214.
  35. Bigagli E, Luceri C, Guasti D, Cinci L. Exosomes secreted from human colon cancer cells influence the adhesion of neighboring metastatic cells: Role of microRNA-210. Cancer Biol Ther. 2016;17:1062-9. doi: 10.1080/15384047.2016.1219815. PubMed PMID: 27611932; PubMed Central PMCID: PMCPMC5079399.
  36. Matsumura T, Sugimachi K, Iinuma H, Takahashi Y, Kurashige J, Sawada G, et al. Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. Br J Cancer. 2015;113:275-81. doi: 10.1038/bjc.2015.201. PubMed PMID: 26057451; PubMed Central PMCID: PMCPMC4506387.
  37. Rezaei R, Baghaei K, Amani D, Piccin A, Hashemi SM, Asadzadeh Aghdaei H, et al. Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells. Life Sci. 2021;269:119035. doi: 10.1016/j.lfs.2021.119035. PubMed PMID: 33450254.
  38. Fu F, Jiang W, Zhou L, Chen Z. Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer. Transl Oncol. 2018;11:221-32. doi: 10.1016/j.tranon.2017.12.012. PubMed PMID: 29367070; PubMed Central PMCID: PMCPMC5789766.
  39. Guo S, Chen J, Chen F, Zeng Q, Liu WL, Zhang G. Exosomes derived from Fusobacterium nucleatum-infected colorectal cancer cells facilitate tumour metastasis by selectively carrying miR-1246/92b-3p/27a-3p and CXCL16. Gut. 2020. doi: 10.1136/gutjnl-2020-321187. PubMed PMID: 33172926.
  40. Hu JL, Wang W, Lan XL, Zeng ZC, Liang YS, Yan YR, et al. CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer. Mol Cancer. 2019;18:91. doi: 10.1186/s12943-019-1019-x. PubMed PMID: 31064356; PubMed Central PMCID: PMCPMC6503554.
  41. Rai A, Greening DW, Chen M, Xu R, Ji H, Simpson RJ. Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome. Proteomics. 2019;19:e1800148. doi: 10.1002/pmic.201800148. PubMed PMID: 30582284.
  42. Wu J, Li H, Xie H, Wu X, Lan P. The malignant role of exosomes in the communication among colorectal cancer cell, macrophage and microbiome. Carcinogenesis. 2019;40:601-10. doi: 10.1093/carcin/bgy138. PubMed PMID: 30864655.
  43. Li H, Li F. Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p. Br J Cancer. 2018;119:744-55. doi: 10.1038/s41416-018-0254-z. PubMed PMID: 30220706; PubMed Central PMCID: PMCPMC6173771.
  44. Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, et al. MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nat Commun. 2017;8:14448. doi: 10.1038/ncomms14448. PubMed PMID: 28211508; PubMed Central PMCID: PMCPMC5321731.
  45. Liu W, Yang D, Chen L, Liu Q, Wang W, Yang Z, et al. Plasma Exosomal miRNA-139-3p is a Novel Biomarker of Colorectal Cancer. J Cancer. 2020;11:4899-906. doi: 10.7150/jca.45548. PubMed PMID: 32626537; PubMed Central PMCID: PMCPMC7330702.
  46. Santasusagna S, Moreno I, Navarro A, Martinez Rodenas F, Hernandez R, Castellano JJ, et al. Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients. Oncology. 2018;95:309-18. doi: 10.1159/000490726. PubMed PMID: 30138915.
  47. Sun L, Liu X, Pan B, Hu X, Zhu Y, Su Y, et al. Serum exosomal miR-122 as a potential diagnostic and prognostic biomarker of colorectal cancer with liver metastasis. J Cancer. 2020;11:630-7. doi: 10.7150/jca.33022. PubMed PMID: 31942186; PubMed Central PMCID: PMCPMC6959047.
  48. Cho WC, Kim M, Park JW, Jeong SY, Ku JL. Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer. Transl Oncol. 2021;14:101000. doi: 10.1016/j.tranon.2020.101000. PubMed PMID: 33352502; PubMed Central PMCID: PMCPMC7758376.
  49. Wang D, Wang X, Si M, Yang J, Sun S, Wu H, et al. Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages. Cancer Lett. 2020;474:36-52. doi: 10.1016/j.canlet.2020.01.005. PubMed PMID: 31931030.
  50. Zhao S, Mi Y, Guan B, Zheng B, Wei P, Gu Y, et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. J Hematol Oncol. 2020;13:156. doi: 10.1186/s13045-020-00991-2. PubMed PMID: 33213490; PubMed Central PMCID: PMCPMC7678301.
  51. Pei W, Wei K, Wu Y, Qiu Q, Zhu H, Mao L, et al. Colorectal cancer tumor cell-derived exosomal miR-203a-3p promotes CRC metastasis by targeting PTEN-induced macrophage polarization. Gene. 2023;885:147692. doi: 10.1016/j.gene.2023.147692. PubMed PMID: 37562585.
  52. Liu K, Dou R, Yang C, Di Z, Shi D, Zhang C, et al. Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier. Carcinogenesis. 2023;44:356-67. doi: 10.1093/carcin/bgad013. PubMed PMID: 36939367.
  53. Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, et al. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 2013;62:1315-26. doi: 10.1136/gutjnl-2011-301846. PubMed PMID: 22735571; PubMed Central PMCID: PMCPMC3787864.
  54. Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008;22:894-907. doi: 10.1101/gad.1640608. PubMed PMID: 18381893; PubMed Central PMCID: PMCPMC2279201.
  55. Paterson EL, Kazenwadel J, Bert AG, Khew-Goodall Y, Ruszkiewicz A, Goodall GJ. Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia. 2013;15:180-91. doi: 10.1593/neo.121828. PubMed PMID: 23441132; PubMed Central PMCID: PMCPMC3579320.
  56. Li J, Du L, Yang Y, Wang C, Liu H, Wang L, et al. MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2. Cancer Lett. 2013;329:84-90. doi: 10.1016/j.canlet.2012.10.019. PubMed PMID: 23111103.
  57. Ji D, Chen Z, Li M, Zhan T, Yao Y, Zhang Z, et al. MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1. Mol Cancer. 2014;13:86. doi: 10.1186/1476-4598-13-86. PubMed PMID: 24755295; PubMed Central PMCID: PMCPMC4021214.
  58. Zhao H, Xu Z, Qin H, Gao Z, Gao L. miR-30b regulates migration and invasion of human colorectal cancer via SIX1. Biochem J. 2014;460:117-25. doi: 10.1042/BJ20131535. PubMed PMID: 24593661.
  59. Park YR, Kim SL, Lee MR, Seo SY, Lee JH, Kim SH, et al. MicroRNA-30a-5p (miR-30a) regulates cell motility and EMT by directly targeting oncogenic TM4SF1 in colorectal cancer. J Cancer Res Clin Oncol. 2017;143:1915-27. doi: 10.1007/s00432-017-2440-4. PubMed PMID: 28528497.
  60. Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, et al. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology. 2013;145:426-36. doi: 10.1053/j.gastro.2013.04.004. PubMed PMID: 23583431.
  61. Gu J, Wang G, Liu H, Xiong C. SATB2 targeted by methylated miR-34c-5p suppresses proliferation and metastasis attenuating the epithelial-mesenchymal transition in colorectal cancer. Cell Prolif. 2018;51:e12455. doi: 10.1111/cpr.12455. PubMed PMID: 29701273; PubMed Central PMCID: PMCPMC6528935.
  62. Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest. 2014;124:1853-67. doi: 10.1172/JCI73531. PubMed PMID: 24642471; PubMed Central PMCID: PMCPMC3973098.
  63. Kim TW, Lee YS, Yun NH, Shin CH, Hong HK, Kim HH, et al. MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer. Br J Cancer. 2020;123:1123-30. doi: 10.1038/s41416-020-0940-5. PubMed PMID: 32546833; PubMed Central PMCID: PMCPMC7524803.
  64. Li J, Xia L, Zhou Z, Zuo Z, Xu C, Song H, et al. MiR-186-5p upregulation inhibits proliferation, metastasis and epithelial-to-mesenchymal transition of colorectal cancer cell by targeting ZEB1. Arch Biochem Biophys. 2018;640:53-60. doi: 10.1016/j.abb.2018.01.002. PubMed PMID: 29325758.
  65. Jackstadt R, Roh S, Neumann J, Jung P, Hoffmann R, Horst D, et al. AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. J Exp Med. 2013;210:1331-50. doi: 10.1084/jem.20120812. PubMed PMID: 23752226; PubMed Central PMCID: PMCPMC3698521.
  66. Shi L, Jackstadt R, Siemens H, Li H, Kirchner T, Hermeking H. p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. Cancer Res. 2014;74:532-42. doi: 10.1158/0008-5472.CAN-13-2203. PubMed PMID: 24285725.
  67. King CE, Cuatrecasas M, Castells A, Sepulveda AR, Lee JS, Rustgi AK. LIN28B promotes colon cancer progression and metastasis. Cancer Res. 2011;71:4260-8. doi: 10.1158/0008-5472.CAN-10-4637. PubMed PMID: 21512136; PubMed Central PMCID: PMCPMC3117110.
  68. Shell S, Park SM, Radjabi AR, Schickel R, Kistner EO, Jewell DA, et al. Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci U S A. 2007;104:11400-5. doi: 10.1073/pnas.0704372104. PubMed PMID: 17600087; PubMed Central PMCID: PMCPMC2040910.
  69. Liu Y, Zhang Y, Wu H, Li Y, Zhang Y, Liu M, et al. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis. Cell Death Dis. 2017;8:e2739. doi: 10.1038/cddis.2017.61. PubMed PMID: 28383561; PubMed Central PMCID: PMCPMC5477594.
  70. Xie Y, Zhao J, Liang Y, Chen M, Luo Y, Cui X, et al. MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Kruppel-like factor 4. Artif Cells Nanomed Biotechnol. 2019;47:1722-9. doi: 10.1080/21691401.2019.1606006. PubMed PMID: 31032663.
  71. Shibuya H, Iinuma H, Shimada R, Horiuchi A, Watanabe T. Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. Oncology. 2010;79:313-20. doi: 10.1159/000323283. PubMed PMID: 21412018.
  72. Cellura D, Pickard K, Quaratino S, Parker H, Strefford JC, Thomas GJ, et al. miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer. Mol Cancer Res. 2015;13:1095-105. doi: 10.1158/1541-7786.MCR-14-0466. PubMed PMID: 25934693; PubMed Central PMCID: PMCPMC4529484.
  73. Zhang J, Xiao Z, Lai D, Sun J, He C, Chu Z, et al. miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. Br J Cancer. 2012;107:352-9. doi: 10.1038/bjc.2012.251. PubMed PMID: 22677902; PubMed Central PMCID: PMCPMC3394980.
  74. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 2008;27:2128-36. doi: 10.1038/sj.onc.1210856. PubMed PMID: 17968323.
  75. Ding M, Zhang T, Li S, Zhang Y, Qiu Y, Zhang B. Correlation analysis between liver metastasis and serum levels of miR200 and miR141 in patients with colorectal cancer. Mol Med Rep. 2017;16:7791-5. doi: 10.3892/mmr.2017.7538. PubMed PMID: 28944840.
  76. Feiersinger F, Nolte E, Wach S, Rau TT, Vassos N, Geppert C, et al. MiRNA-21 Expression Decreases from Primary Tumors to Liver Metastases in Colorectal Carcinoma. PLoS One. 2016;11:e0148580. doi: 10.1371/journal.pone.0148580. PubMed PMID: 26845148; PubMed Central PMCID: PMCPMC4741388.
  77. Arabsorkhi Z, Gharib E, Yaghmoorian Khojini J, Farhadieh ME, Nazemalhosseini-Mojarad E, Zali MR. miR-298 plays a pivotal role in colon cancer invasiveness by targeting PTEN. J Cell Physiol. 2020;235:4335-50. doi: 10.1002/jcp.29310. PubMed PMID: 31621072.
  78. Cheng D, Zhao S, Tang H, Zhang D, Sun H, Yu F, et al. MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4. Oncotarget. 2016;7:45199-213. doi: 10.18632/oncotarget.9900. PubMed PMID: 27286257; PubMed Central PMCID: PMCPMC5216716.
  79. Li J, Chen Y, Guo X, Zhou L, Jia Z, Tang Y, et al. Inhibition of miR-15b decreases cell migration and metastasis in colorectal cancer. Tumour Biol. 2016;37:8765-73. doi: 10.1007/s13277-015-4396-9. PubMed PMID: 26743779.
  80. Wang Y, Sun J, Wei X, Luan L, Zeng X, Wang C, et al. Decrease of miR-622 expression suppresses migration and invasion by targeting regulation of DYRK2 in colorectal cancer cells. Onco Targets Ther. 2017;10:1091-100. doi: 10.2147/OTT.S125724. PubMed PMID: 28260923; PubMed Central PMCID: PMCPMC5328604.
  81. Lam CS, Ng L, Chow AK, Wan TM, Yau S, Cheng NS, et al. Identification of microRNA 885-5p as a novel regulator of tumor metastasis by targeting CPEB2 in colorectal cancer. Oncotarget. 2017;8:26858-70. doi: 10.18632/oncotarget.15844. PubMed PMID: 28460469; PubMed Central PMCID: PMCPMC5432302.
  82. Zhang T, Guo J, Gu J, Wang Z, Wang G, Li H, et al. Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments. Oncol Rep. 2019;41:279-91. doi: 10.3892/or.2018.6840. PubMed PMID: 30542696; PubMed Central PMCID: PMCPMC6278419.
  83. Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, et al. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis. Gut. 2016;65:977-89. doi: 10.1136/gutjnl-2015-309372. PubMed PMID: 25804630; PubMed Central PMCID: PMCPMC4581915.
  84. Zou G, Wang R, Wang M. Clinical response and prognostic significance of serum miR-497 expression in colorectal cancer. Cancer Biomark. 2019;25:11-8. doi: 10.3233/CBM-181902. PubMed PMID: 31006664.
  85. Qiu Y, Yu H, Shi X, Xu K, Tang Q, Liang B, et al. microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A. Cell Prolif. 2016;49:69-78. doi: 10.1111/cpr.12237. PubMed PMID: 26840372; PubMed Central PMCID: PMCPMC6495881.
  86. Qiu YY, Hu Q, Tang QF, Feng W, Hu SJ, Liang B, et al. MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis. Tumour Biol. 2014;35:2599-606. doi: 10.1007/s13277-013-1342-6. PubMed PMID: 24375248.
  87. Hong S, Yan Z, Song Y, Bi M, Li S. LncRNA AGAP2-AS1 augments cell viability and mobility, and confers gemcitabine resistance by inhibiting miR-497 in colorectal cancer. Aging (Albany NY). 2020;12:5183-94. doi: 10.18632/aging.102940. PubMed PMID: 32202509; PubMed Central PMCID: PMCPMC7138564.
  88. Zhang N, Shen Q, Zhang P. miR-497 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer cells by targeting fos-related antigen-1. Onco Targets Ther. 2016;9:6597-604. doi: 10.2147/OTT.S114609. PubMed PMID: 27822064; PubMed Central PMCID: PMCPMC5087769.
  89. Li W, Chen A, Xiong L, Chen T, Tao F, Lu Y, et al. miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1. Tumour Biol. 2017;39:1010428317698389. doi: 10.1177/1010428317698389. PubMed PMID: 28466778.
  90. Li W, Chang J, Wang S, Liu X, Peng J, Huang D, et al. miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. Oncotarget. 2015;6:24448-62. doi: 10.18632/oncotarget.4423. PubMed PMID: 26259252; PubMed Central PMCID: PMCPMC4695197.
  91. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest. 2011;121:4526-36. doi: 10.1172/JCI45008. PubMed PMID: 21985787; PubMed Central PMCID: PMCPMC3204827.
  92. Chen DL, Wang ZQ, Zeng ZL, Wu WJ, Zhang DS, Luo HY, et al. Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. Hepatology. 2014;60:598-609. doi: 10.1002/hep.27118. PubMed PMID: 24616020.
  93. Li Y, Sun Z, Liu B, Shan Y, Zhao L, Jia L. Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer. Cell Death Dis. 2017;8:e2892. doi: 10.1038/cddis.2017.281. PubMed PMID: 28640257; PubMed Central PMCID: PMCPMC5520934.
  94. Laudato S, Patil N, Abba ML, Leupold JH, Benner A, Gaiser T, et al. P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1. Int J Cancer. 2017;141:1879-90. doi: 10.1002/ijc.30854. PubMed PMID: 28656629.
  95. Fan M, Ma X, Wang F, Zhou Z, Zhang J, Zhou D, et al. MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b. Cancer Lett. 2020;477:144-56. doi: 10.1016/j.canlet.2020.02.021. PubMed PMID: 32112903.
  96. Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, Pehserl AM, Reicher A, Resel M, et al. miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5. Clin Cancer Res. 2017;23:5255-66. doi: 10.1158/1078-0432.CCR-17-0023. PubMed PMID: 28533224.
  97. Luo M, Hu Z, Kong Y, Li L. MicroRNA-432-5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer. Exp Ther Med. 2021;21:301. doi: 10.3892/etm.2021.9732. PubMed PMID: 33717244; PubMed Central PMCID: PMCPMC7885074.
  98. Pan S, Ren F, Li L, Liu D, Li Y, Wang A, et al. MiR-328-3p inhibits cell proliferation and metastasis in colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt signaling pathway. Exp Cell Res. 2020;390:111939. doi: 10.1016/j.yexcr.2020.111939. PubMed PMID: 32142853.
  99. Hong YG, Xin C, Zheng H, Huang ZP, Yang Y, Zhou JD, et al. miR-365a-3p regulates ADAM10-JAK-STAT signaling to suppress the growth and metastasis of colorectal cancer cells. J Cancer. 2020;11:3634-44. doi: 10.7150/jca.42731. PubMed PMID: 32284760; PubMed Central PMCID: PMCPMC7150465.
  100. Hata T, Mokutani Y, Takahashi H, Inoue A, Munakata K, Nagata K, et al. Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer. Int J Oncol. 2017;50:487-96. doi: 10.3892/ijo.2016.3813. PubMed PMID: 28000854.
  101. Bleau AM, Redrado M, Nistal-Villan E, Villalba M, Exposito F, Redin E, et al. miR-146a targets c-met and abolishes colorectal cancer liver metastasis. Cancer Lett. 2018;414:257-67. doi: 10.1016/j.canlet.2017.11.008. PubMed PMID: 29133238.
  102. Guo L, Fu J, Sun S, Zhu M, Zhang L, Niu H, et al. MicroRNA-143-3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3. Cancer Sci. 2019;110:805-16. doi: 10.1111/cas.13910. PubMed PMID: 30536996; PubMed Central PMCID: PMCPMC6361562.
  103. Mokutani Y, Uemura M, Munakata K, Okuzaki D, Haraguchi N, Takahashi H, et al. Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer. Ann Surg Oncol. 2016;23:599-608. doi: 10.1245/s10434-016-5133-3. PubMed PMID: 26868958; PubMed Central PMCID: PMCPMC5149564.
  104. Hansen TF, Nielsen BS, Jakobsen A, Sorensen FB. Intra-tumoural vessel area estimated by expression of epidermal growth factor-like domain 7 and microRNA-126 in primary tumours and metastases of patients with colorectal cancer: a descriptive study. J Transl Med. 2015;13:10. doi: 10.1186/s12967-014-0359-y. PubMed PMID: 25592646; PubMed Central PMCID: PMCPMC4302134.
  105. Zhong L, Simoneau B, Huot J, Simard MJ. p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription. Oncotarget. 2017;8:1678-87. doi: 10.18632/oncotarget.13779. PubMed PMID: 27926494; PubMed Central PMCID: PMCPMC5352088.
  106. Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, et al. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 2012;72:3631-41. doi: 10.1158/0008-5472.CAN-12-0667. PubMed PMID: 22593189.
  107. Hedayat S, Cascione L, Cunningham D, Schirripa M, Lampis A, Hahne JC, et al. Circulating microRNA Analysis in a Prospective Co-clinical Trial Identifies MIR652-3p as a Response Biomarker and Driver of Regorafenib Resistance Mechanisms in Colorectal Cancer. Clin Cancer Res. 2024;30:2140-59. doi: 10.1158/1078-0432.CCR-23-2748. PubMed PMID: 38376926.
  108. Machackova T, Vychytilova-Faltejskova P, Souckova K, Trachtova K, Brchnelova D, Svoboda M, et al. MiR-215-5p Reduces Liver Metastasis in an Experimental Model of Colorectal Cancer through Regulation of ECM-Receptor Interactions and Focal Adhesion. Cancers (Basel). 2020;12. doi: 10.3390/cancers12123518. PubMed PMID: 33255928; PubMed Central PMCID: PMCPMC7760708.
  109. Nassar FJ, Msheik ZS, Itani MM, Helou RE, Hadla R, Kreidieh F, et al. Circulating miRNA as Biomarkers for Colorectal Cancer Diagnosis and Liver Metastasis. Diagnostics (Basel). 2021;11. doi: 10.3390/diagnostics11020341. PubMed PMID: 33669508; PubMed Central PMCID: PMCPMC7921943.
  110. Gmeiner WH. Recent Advances in Therapeutic Strategies to Improve Colorectal Cancer Treatment. Cancers (Basel). 2024;16. doi: 10.3390/cancers16051029. PubMed PMID: 38473386; PubMed Central PMCID: PMCPMC10930828.
  111. Karaca C, Demir Karaman E, Leblebici A, Kurter H, Ellidokuz H, Koc A, et al. New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses. Sci Rep. 2024;14:8762. doi: 10.1038/s41598-024-59101-8. PubMed PMID: 38627442; PubMed Central PMCID: PMCPMC11021540.
  112. Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA. 2008;299:425-36. doi: 10.1001/jama.299.4.425. PubMed PMID: 18230780; PubMed Central PMCID: PMCPMC2614237.
  113. Beg MS, Brenner AJ, Sachdev J, Borad M, Kang YK, Stoudemire J, et al. Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors. Invest New Drugs. 2017;35:180-8. doi: 10.1007/s10637-016-0407-y. PubMed PMID: 27917453; PubMed Central PMCID: PMCPMC5893501.
  114. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010;17:193-9. doi: 10.1038/cdd.2009.56. PubMed PMID: 19461653.
  115. Nedaeinia R, Sharifi M, Avan A, Kazemi M, Nabinejad A, Ferns GA, et al. Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4. Tumour Biol. 2017;39:1010428317692261. doi: 10.1177/1010428317692261. PubMed PMID: 28347230.
  116. Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, et al. In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases. Mol Ther. 2017;25:1588-95. doi: 10.1016/j.ymthe.2017.04.005. PubMed PMID: 28457664; PubMed Central PMCID: PMCPMC5498809.
  117. Torres S, Garcia-Palmero I, Bartolome RA, Fernandez-Acenero MJ, Molina E, Calvino E, et al. Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. J Pathol. 2017;242:39-51. doi: 10.1002/path.4874. PubMed PMID: 28054337.
  118. Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, et al. Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis. Cancer Res. 2022;82:105-13. doi: 10.1158/0008-5472.CAN-21-2269. PubMed PMID: 34753773; PubMed Central PMCID: PMCPMC8732321.
  119. Liu W, Wang X. Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data. Genome Biol. 2019;20:18. doi: 10.1186/s13059-019-1629-z. PubMed PMID: 30670076; PubMed Central PMCID: PMCPMC6341724.
  120. Kim T, Croce CM. MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies. Exp Mol Med. 2023;55:1314-21. doi: 10.1038/s12276-023-01050-9. PubMed PMID: 37430087; PubMed Central PMCID: PMCPMC10394030.
آمار
تعداد مشاهده مقاله: 71
تعداد دریافت فایل اصل مقاله: 23


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب