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Interaction Between Tfh/Tfr Ratio and Regulatory B Cell in Autoimmune Diseases | ||
| Iranian Journal of Immunology | ||
| دوره 22، شماره 1، خرداد 2025، صفحه 1-1 اصل مقاله (1.5 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2025.103848.2859 | ||
| نویسندگان | ||
| Chunhong Zhu1، 2؛ Xiaoying Ni3؛ Jiangming Xu2؛ Hao Wang* 1؛ Hongqiang Shen1 | ||
| 1Department of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. | ||
| 2Wangjiang Subdistrict Community Healthcare Center, Shangcheng District, Hangzhou, China. | ||
| 3Department of Pediatrics, No.903 Hospital of PLA Joint Logistic Support Force, Xi Hu Affiliated Hospital of Hangzhou Medical College, Hangzhou, China. | ||
| چکیده | ||
| The balance between follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) is crucial for maintaining immune tolerance. Tfh cells are key in producing autoantibodies by providing essential help to germinal center (GC) B cells, while Tfr cells prevent autoimmune inflammatory processes by controling Tfh responses. However, the signals that regulate Tfh and Tfr cells are largely unknown. Due to dysregulated Tfr/Tfh balance and autoantibody production, regulatory B cells (Bregs) have emerged as a key checkpoint in the GC response. Bregs are B cells with immunosuppressive capabilities. Significant advancements have been made in understanding the roles of Bregs, particularly their capacity to produce cytokines with anti-inflammatory properties and regulate Th17, Th1, and regulatory T cells (Tregs) in the context of autoimmune conditions. Bregs also play a pivotal role in shaping the development, regulation, and localization of Tfh and Tfr cells within the immune environment. Consequently, gaining mechanistic knowledge about the interactions between Tfh-Bregs and Tfr-Bregs has the potential to establish homeostasis and suppress the development of autoantibodies in a various disorders. Within the context of autoimmune disorders, this article provides a concise summary of the dysregulation of Tfh/Tfr, highlighting the critical role of Bregs in regulating this balance. The previously unrecognized interplay between Bregs and Tfh/Tfr cells will serve as an essential basis for the comprehension and management of autoimmune illnesses. It also promises to offer invaluable knowledge of the biological mechanisms of autoantibody synthesis. | ||
| کلیدواژه‌ها | ||
| Autoantibody؛ Autoimmune disease؛ Follicular helper T cell؛ Follicular regulatory T cell؛ Regulatory B cell | ||
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آمار تعداد مشاهده مقاله: 261 تعداد دریافت فایل اصل مقاله: 210 |
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