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Balvasi, Elnaz, Mahmoudi, Farshid, Farina, Parastoo, Ameri, Ali, Jafari, Fatemeh, Geraily, Ghazale. (1405). A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes. سامانه مدیریت نشریات علمی, 16(4), 285-296. doi: 10.31661/jbpe.v0i0.2410-1835
Elnaz Balvasi; Farshid Mahmoudi; Parastoo Farina; Ali Ameri; Fatemeh Jafari; Ghazale Geraily. "A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes". سامانه مدیریت نشریات علمی, 16, 4, 1405, 285-296. doi: 10.31661/jbpe.v0i0.2410-1835
Balvasi, Elnaz, Mahmoudi, Farshid, Farina, Parastoo, Ameri, Ali, Jafari, Fatemeh, Geraily, Ghazale. (1405). 'A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes', سامانه مدیریت نشریات علمی, 16(4), pp. 285-296. doi: 10.31661/jbpe.v0i0.2410-1835
Balvasi, Elnaz, Mahmoudi, Farshid, Farina, Parastoo, Ameri, Ali, Jafari, Fatemeh, Geraily, Ghazale. A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes. سامانه مدیریت نشریات علمی, 1405; 16(4): 285-296. doi: 10.31661/jbpe.v0i0.2410-1835

A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes

Journal of Biomedical Physics and Engineering
مقاله 3، دوره 16، شماره 4 - شماره پیاپی 1، آبان 2026، صفحه 285-296    اصل مقاله (1.69 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2410-1835
نویسندگان
Elnaz Balvasi1؛ Farshid Mahmoudi* 2؛ Parastoo Farina1، 3؛ Ali Ameri4، 5؛ Fatemeh Jafari6؛ Ghazale Geraily* 1، 6
1Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran
3Research Center for Intelligent Technologies in Medicine (RCITM), Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences (TUMS), Tehran, Iran
4Department of Physics, Stockholm University, Sweden
5Department of Oncology and Pathology, Karolinska Institutet, Sweden
6Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Spatially Fractionated Radiotherapy (SFRT) can be implemented using Volumetric-Modulated Arc Therapy (VMAT) in either two-dimensional (2D) or three-dimensional (3D) configurations.
Objective: This study aimed to compare the dosimetric and clinical outcomes of two VMAT-based SFRT techniques for large lung tumors.
Material and Methods: In this experimental study, SFRT plans were designed for each patient using cylindrical and spherical grid targets. Single-fraction prescription doses of 15 and 20 Gy were delivered to the grid target isocenters using 6 MV Flattening-filter-free (FFF) photon beams.
Results: The 2D SFRT plan demonstrated higher Gross Tumor Volume (GTV) mean dose, GTV Equivalent Uniform Dose (EUD), and Valley-to-peak Dose ratio (VPDR) compared to the 3D lattice plan. However, the 3D Lattice Radiotherapy (3D-LRT) technique provided a better therapeutic ratio and more uniform valley-peak dose distribution. Both plans demonstrated therapeutic ratios greater than one with minimal Normal Tissue Complication Probability (NTCP). 
Conclusion: Both 2D and 3D lattice VMAT-based SFRT techniques effectively delivered high radiation doses with steep dose gradients within the GTV, minimizing normal tissue exposure and reducing the risk of complications.

تازه های تحقیق

Farshid Mahmoudi (Google Scholar)

کلیدواژه‌ها
Spatially Fractionated Radiotherapy؛ Volumetric-Modulated Arc Therapy؛ Lattice Radiotherapy؛ Grid Target؛ Lung Neoplasms؛ Treatment Outcome؛ Dose Fractionation, Radiation
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