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Assessment of Some Trace Metals in Head and Neck Squamous Cell Carcinoma: A Case-Control Study | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 اسفند 1403 اصل مقاله (616.25 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2025.104402.2534 | ||
| نویسندگان | ||
| Zohreh Dalirsani1؛ Zahra Delavarian1؛ Atessa Pakfetrat* 1؛ Isaac Hashemy2؛ Leyla Vazifeh Mostaan3؛ Fahimeh Khaghani4؛ Mahboobeh Taherizadeh5؛ Maede Shokri6؛ Hossein Alavi7 | ||
| 1Oral and Maxillofacial Medicine, Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 2Dept. of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 3Dept. of Otolaryngology, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 4Dept. of Periodontics, North Khorasan University of Medical Sciences, Bojnourd, Iran. | ||
| 5Master Degree of Mathematical Statistics, Mashhad, Iran. | ||
| 6General Dentist, Mashhad, Iran. | ||
| 7Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| چکیده | ||
| Background: Micronutrients and trace elements have been linked to the development of head and neck squamous cell carcinoma (HNSCC). However, the role of these elements in the etiology of HNSCC remains unclear. Purpose: This study was conducted to investigate the association between micronutrient and trace element levels and the risk of HNSCC. Materials and Method: In this case-control study, serum concentrations of iron, selenium, zinc, copper, and calcium were measured in 40 patients with HNSCC and compared to those of 37 healthy subjects. Statistical analysis was conducted using the Mann-Whitney test, Chi-square test, and independent t-test. Results: The mean ages of the case and control groups were 62.80±13.029 and 57.92± 9.367, respectively, with 45% of HNSCC patients and 59.5% of control subjects being male (p= 0.205). Serum concentrations of calcium and copper were higher, and those of selenium, zinc, and iron lower in the case group than in the control group. Adjusted logistic regression showed only copper, calcium, and iron concentrations to be significantly different between the two groups (p= 0.003, p= 0.018, and p= 0.047, respectively). Conclusion: The case group had lower levels of iron, zinc, and selenium, and higher levels of calcium and copper than the control group. Evaluating serum concentrations of these trace metals could be useful for further screening of individuals at high risk. | ||
| کلیدواژه‌ها | ||
| Micronutrients؛ Trace elements؛ Squamous cell carcinoma of head and neck؛ Neoplasms | ||
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آمار تعداد مشاهده مقاله: 33 تعداد دریافت فایل اصل مقاله: 17 |
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