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Alam-Rahnama, Tannaz, Shafiekhani, Mojtaba, Behdadian, Shokooh, Karimzadeh, Iman. (1403). The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study. سامانه مدیریت نشریات علمی, 11(1), 1-16. doi: 10.30476/tips.2025.105143.1276
Tannaz Alam-Rahnama; Mojtaba Shafiekhani; Shokooh Behdadian; Iman Karimzadeh. "The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study". سامانه مدیریت نشریات علمی, 11, 1, 1403, 1-16. doi: 10.30476/tips.2025.105143.1276
Alam-Rahnama, Tannaz, Shafiekhani, Mojtaba, Behdadian, Shokooh, Karimzadeh, Iman. (1403). 'The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study', سامانه مدیریت نشریات علمی, 11(1), pp. 1-16. doi: 10.30476/tips.2025.105143.1276
Alam-Rahnama, Tannaz, Shafiekhani, Mojtaba, Behdadian, Shokooh, Karimzadeh, Iman. The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study. سامانه مدیریت نشریات علمی, 1403; 11(1): 1-16. doi: 10.30476/tips.2025.105143.1276

The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study

Trends in Pharmaceutical Sciences
مقاله 1، دوره 11، شماره 1، خرداد 2025، صفحه 1-16    اصل مقاله (464.22 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.105143.1276
نویسندگان
Tannaz Alam-Rahnama1، 2؛ Mojtaba Shafiekhani2، 3؛ Shokooh Behdadian1، 2؛ Iman Karimzadeh* 2
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Kidney transplant recipients are at higher risk of developing coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the pattern, pharmacotherapy, drug interactions, and clinical outcome of COVID-19 in kidney transplant recipients at a referral center in Iran. This retrospective, observational study was conducted in Abu Ali Sina Organ transplantation center in Shiraz, Iran. All adult kidney transplant patients diagnosed with COVID-19 and hospitalized for at least 48 hours were included. Required data were collected by reviewing medical charts and health information system of patients at hospital. Potential drug-drug interactions were identified using Lexi-Interact online as well as the Liverpool interactions online website. A total of 108 patients were included. Fever, cough, and shortness of breath were the most common clinical symptoms. About three-fourth (74%) of patients had non-severe COVID-19. Remdesivir was the most widely used antiviral agent. mTOR inhibitors and anti-metabolites were either dose reduced or discontinued in 100% and 80.2% of cases, respectively. Age (odds ratio [OR] = 1.06, 95% [Cl] = 1.02-1.09), calcineurin inhibitor adjustment (OR = 0.26, 95% Cl = 0.09-0.75), baseline white blood cell count (OR = 1.13, 95% Cl = 1.01-1.28), baseline serum lactate dehydrogenase level (OR = 1.32, 95% Cl = 1.03-1.69), administration of tocilizumab (OR = 0.06, 95% Cl = 0.07-0.54), and the severity of COVID-19 disease (OR = 0.03, 95% Cl = 0.00-0.03) had significant association with mortality.  The present investigation found that COVID-19 infection in kidney transplant patients may be severe and require hospitalization and even, critical care. 

تازه های تحقیق

Mojtaba Shafiekhani (Google Scholar)

Iman Karimzadeh (Google Scholar)

کلیدواژه‌ها
Kidney Transplantation؛ COVID 19؛ Pharmacotherapy؛ Drug Interactions
سایر فایل های مرتبط با مقاله
مراجع
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