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Fatemi, Amirreza, Raee, Mohammad Javad, Tamaddon, Ali Mohammad, Sadeghian, Sara, Amiri, Salmeh, Firouzabadi, Dena, Farvadi, Fakhrossadat. (1403). Preparation and In-vitro Characterization of Giant Superparamagnetic Nanobeads: A Proof of Concept. سامانه مدیریت نشریات علمی, 11(1), 17-28. doi: 10.30476/tips.2025.104304.1261
Amirreza Fatemi; Mohammad Javad Raee; Ali Mohammad Tamaddon; Sara Sadeghian; Salmeh Amiri; Dena Firouzabadi; Fakhrossadat Farvadi. "Preparation and In-vitro Characterization of Giant Superparamagnetic Nanobeads: A Proof of Concept". سامانه مدیریت نشریات علمی, 11, 1, 1403, 17-28. doi: 10.30476/tips.2025.104304.1261
Fatemi, Amirreza, Raee, Mohammad Javad, Tamaddon, Ali Mohammad, Sadeghian, Sara, Amiri, Salmeh, Firouzabadi, Dena, Farvadi, Fakhrossadat. (1403). 'Preparation and In-vitro Characterization of Giant Superparamagnetic Nanobeads: A Proof of Concept', سامانه مدیریت نشریات علمی, 11(1), pp. 17-28. doi: 10.30476/tips.2025.104304.1261
Fatemi, Amirreza, Raee, Mohammad Javad, Tamaddon, Ali Mohammad, Sadeghian, Sara, Amiri, Salmeh, Firouzabadi, Dena, Farvadi, Fakhrossadat. Preparation and In-vitro Characterization of Giant Superparamagnetic Nanobeads: A Proof of Concept. سامانه مدیریت نشریات علمی, 1403; 11(1): 17-28. doi: 10.30476/tips.2025.104304.1261

Preparation and In-vitro Characterization of Giant Superparamagnetic Nanobeads: A Proof of Concept

Trends in Pharmaceutical Sciences
مقاله 2، دوره 11، شماره 1، خرداد 2025، صفحه 17-28    اصل مقاله (836.99 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.104304.1261
نویسندگان
Amirreza Fatemi1؛ Mohammad Javad Raee2، 3؛ Ali Mohammad Tamaddon4؛ Sara Sadeghian5؛ Salmeh Amiri4؛ Dena Firouzabadi6؛ Fakhrossadat Farvadi* 4
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
The isolation of biomolecules from complex biological environments is a crucial step in the accurate analysis of biomarkers, which in turn is vital for enhancing the precision of medical diagnoses. Among the various techniques employed for biomarker separation, immunomagnetic separation utilizing superparamagnetic iron oxide nanoparticles (SPIONs) has emerged as a promising approach. Nonetheless, the diminutive size of SPIONs poses challenges regarding their robustness, particularly in the efficient extraction of macromolecules from diverse biological samples. This study addresses this pressing concern by investigating methods to enhance the magnetic properties of these nanoparticles. Specifically, we focus on increasing the magnetic unit size while preserving their superparamagnetic characteristics. Through a novel methodological approach, we successfully created giant superparamagnetic nanoclusters via click binding of biotinylated SPIONs with avidin macromolecules. These large nanoclusters exhibited favorable magnetic properties, indicating their potential for significant application in biomarker discovery and analysis, thus paving the way for advancements in biomedical diagnostics. 

تازه های تحقیق

Mohammad Javad Raee (Google Scholar)

Ali Mohammad Tamaddon (Google Scholar)

Dena Firouzabadi (Google Scholar)

Fakhrossadat Farvadi (Google Scholar)

کلیدواژه‌ها
Superparamagnetic؛ Nanoparticle؛ Nanocluster؛ Immunomagnetic separation
مراجع
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