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Munuswamy, Nivetha, Kumar, Pola Govardhan, Shanmugasundaram, Rajendran, Venkatesh, Sreedevi B.. (1403). Spontaneous Hemoperitoneum Caused by Malignant Gastrointestinal Stromal Tumor: A Case Report. سامانه مدیریت نشریات علمی, 50(2), 124-128. doi: 10.30476/ijms.2024.104038.3751
Nivetha Munuswamy; Pola Govardhan Kumar; Rajendran Shanmugasundaram; Sreedevi B. Venkatesh. "Spontaneous Hemoperitoneum Caused by Malignant Gastrointestinal Stromal Tumor: A Case Report". سامانه مدیریت نشریات علمی, 50, 2, 1403, 124-128. doi: 10.30476/ijms.2024.104038.3751
Munuswamy, Nivetha, Kumar, Pola Govardhan, Shanmugasundaram, Rajendran, Venkatesh, Sreedevi B.. (1403). 'Spontaneous Hemoperitoneum Caused by Malignant Gastrointestinal Stromal Tumor: A Case Report', سامانه مدیریت نشریات علمی, 50(2), pp. 124-128. doi: 10.30476/ijms.2024.104038.3751
Munuswamy, Nivetha, Kumar, Pola Govardhan, Shanmugasundaram, Rajendran, Venkatesh, Sreedevi B.. Spontaneous Hemoperitoneum Caused by Malignant Gastrointestinal Stromal Tumor: A Case Report. سامانه مدیریت نشریات علمی, 1403; 50(2): 124-128. doi: 10.30476/ijms.2024.104038.3751

Spontaneous Hemoperitoneum Caused by Malignant Gastrointestinal Stromal Tumor: A Case Report

Iranian Journal of Medical Sciences
مقاله 7، دوره 50، شماره 2، اردیبهشت 2025، صفحه 124-128    اصل مقاله (1.32 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.104038.3751
نویسندگان
Nivetha Munuswamy1؛ Pola Govardhan Kumar* 1؛ Rajendran Shanmugasundaram2؛ Sreedevi B. Venkatesh1
1Department of General Surgery, Sree Balaji Medical College and Hospital, Chennai, India
2Department of Surgical Gastroenterology, Sree Balaji Medical College and Hospital, Chennai, India
چکیده
Gastrointestinal stromal tumors (GIST) are less prevalent mesenchymal tumors, accounting for 1% of gastrointestinal malignancies. Spontaneous hemoperitoneum (SH) following gastric GIST rupture is a rare occurrence. The present study described a case of a 67-year-old female who presented with acute onset abdominal pain. Vital signs at the time of presentation were unstable. Contrast-enhanced computed tomography (CECT) of the abdomen revealed a mixed-density mass lesion with multiple hyperdense areas within. A hemogram indicated a low hemoglobin level. An emergency laparotomy revealed a ruptured pedunculated, friable mass with active bleeding arising from the lesser curvature of the stomach. A wedge resection was carried out to achieve a gross negative margin of the mass. Final pathology confirmed GIST epitheloid type with positive margins (pT3N0M0-pathologically tumor size within 10 cm with no nodal or distant metastasis) and positive for CD117, DOG1.
Given the tumor rupture and positive margins, the patient was started on imatinib mesylate therapy. As demonstrated in this case, GIST rarely ruptures, resulting in hemoperitoneum. The primary treatment approach is surgical exploration and resection.
کلیدواژه‌ها
Gastrointestinal stromal tumors؛ Hemoperitoneum؛ Rupture
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مراجع
  1. Cobbold C, Wileman T. The major structural protein of African swine fever virus, p73, is packaged into large structures, indicative of viral capsid or matrix precursors, on the endoplasmic reticulum. J Virol. 1998;72:5215-23. doi: 10.1128/JVI.72.6.5215-5223.1998. PubMed PMID: 9573294; PubMed Central PMCID: PMCPMC110101.
  2. Serrano C, Martin-Broto J, Asencio-Pascual JM, Lopez-Guerrero JA, Rubio-Casadevall J, Bague S, et al. 2023 GEIS Guidelines for gastrointestinal stromal tumors. Ther Adv Med Oncol. 2023;15:17588359231192388. doi: 10.1177/17588359231192388. PubMed PMID: 37655207; PubMed Central PMCID: PMCPMC10467260.
  3. Parab TM, DeRogatis MJ, Boaz AM, Grasso SA, Issack PS, Duarte DA, et al. Gastrointestinal stromal tumors: a comprehensive review. J Gastrointest Oncol. 2019;10:144-54. doi: 10.21037/jgo.2018.08.20. PubMed PMID: 30788170; PubMed Central PMCID: PMCPMC6351301.
  4. Connolly EM, Gaffney E, Reynolds JV. Gastrointestinal stromal tumours. Br J Surg. 2003;90:1178-86. doi: 10.1002/bjs.4352. PubMed PMID: 14515284.
  5. Alawawdeh F, Al-Tkrit A, Aneeb M, Mekaiel A, Mehta A. Gastrointestinal Stromal Tumor: An Uncommon but Serious Cause of Gastrointestinal Bleeding. J Med Cases. 2021;12:74-8. doi: 10.14740/jmc3631. PubMed PMID: 34434434; PubMed Central PMCID: PMCPMC8383613.
  6. Gong J, Kang W, Zhu J, Xu J. CT and MR imaging of gastrointestinal stromal tumor of stomach: a pictorial review. Quant Imaging Med Surg. 2012;2:274-9. doi: 10.3978/j.issn.2223-4292.2012.11.01. PubMed PMID: 23289087; PubMed Central PMCID: PMCPMC3533593.
  7. Furlan A, Fakhran S, Federle MP. Spontaneous abdominal hemorrhage: causes, CT findings, and clinical implications. AJR Am J Roentgenol. 2009;193:1077-87. doi: 10.2214/AJR.08.2231. PubMed PMID: 19770332.
  8. Behi H, Omry A, Guelmami H, Changuel A, Kamtaoui A, Khalifa MB. A case report: Peritonitis secondary to perforated locally advanced gastrointestinal stromal tumor. Int J Surg Case Rep. 2024;119:109739. doi: 10.1016/j.ijscr.2024.109739. PubMed PMID: 38728971; PubMed Central PMCID: PMCPMC11101896.
  9. Shively J, Ebersbacher C, Walsh WT, Allemang MT. Spontaneous Hemoperitoneum From a Ruptured Gastrointestinal Stromal Tumor. Cureus. 2020;12:e9338. doi: 10.7759/cureus.9338. PubMed PMID: 32850212; PubMed Central PMCID: PMCPMC7444847.
  10. Griffith AM, Olpin JD. Imaging of gastrointestinal stromal tumors. Current Radiology Reports. 2022;10:129-39. doi: 10.1007/s40134-022-00401-0.
  11. Goto O, Kaise M, Iwakiri K. Advancements in the Diagnosis of Gastric Subepithelial Tumors. Gut Liver. 2022;16:321-30. doi: 10.5009/gnl210242. PubMed PMID: 34456187; PubMed Central PMCID: PMCPMC9099397.
  12. Joensuu H, Wardelmann E, Sihto H, Eriksson M, Sundby Hall K, Reichardt A, et al. Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib: An Exploratory Analysis of a Randomized Clinical Trial. JAMA Oncol. 2017;3:602-9. doi: 10.1001/jamaoncol.2016.5751. PubMed PMID: 28334365; PubMed Central PMCID: PMCPMC5470395
  13. Ahmed M. Recent advances in the management of gastrointestinal stromal tumor. World J Clin Cases. 2020;8:3142-55. doi: 10.12998/wjcc.v8.i15.3142. PubMed PMID: 32874969; PubMed Central PMCID: PMCPMC7441252.
  14. Mohammadi M, NS IJ, Hollander DD, Bleckman RF, Oosten AW, Desar IME, et al. Improved Efficacy of First-Line Imatinib in Advanced Gastrointestinal Stromal Tumors (GIST): The Dutch GIST Registry Data. Target Oncol. 2023;18:415-23. doi: 10.1007/s11523-023-00960-y. PubMed PMID: 37079223; PubMed Central PMCID: PMCPMC10191911
  15. Schnadig ID, Blanke CD. Gastrointestinal stromal tumors: imatinib and beyond. Curr Treat Options Oncol. 2006;7:427-37. doi: 10.1007/s11864-006-0018-5. PubMed PMID: 17032555.
  16. Joensuu H, Vehtari A, Riihimaki J, Nishida T, Steigen SE, Brabec P, et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol. 2012;13:265-74. doi: 10.1016/S1470-2045(11)70299-6. PubMed PMID: 22153892.
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