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Pakroo, Mahsa, Mortazavi, Seyed Ali Reza, Mortazavi, Seyed Mohammad Javad. (1404). Enhancing Astronaut Resilience: The Role of Elevated ROS in Adapting to Space Radiation. سامانه مدیریت نشریات علمی, 16(1), 81-84. doi: 10.31661/jbpe.v0i0.2407-1791
Mahsa Pakroo; Seyed Ali Reza Mortazavi; Seyed Mohammad Javad Mortazavi. "Enhancing Astronaut Resilience: The Role of Elevated ROS in Adapting to Space Radiation". سامانه مدیریت نشریات علمی, 16, 1, 1404, 81-84. doi: 10.31661/jbpe.v0i0.2407-1791
Pakroo, Mahsa, Mortazavi, Seyed Ali Reza, Mortazavi, Seyed Mohammad Javad. (1404). 'Enhancing Astronaut Resilience: The Role of Elevated ROS in Adapting to Space Radiation', سامانه مدیریت نشریات علمی, 16(1), pp. 81-84. doi: 10.31661/jbpe.v0i0.2407-1791
Pakroo, Mahsa, Mortazavi, Seyed Ali Reza, Mortazavi, Seyed Mohammad Javad. Enhancing Astronaut Resilience: The Role of Elevated ROS in Adapting to Space Radiation. سامانه مدیریت نشریات علمی, 1404; 16(1): 81-84. doi: 10.31661/jbpe.v0i0.2407-1791

Enhancing Astronaut Resilience: The Role of Elevated ROS in Adapting to Space Radiation

Journal of Biomedical Physics and Engineering
دوره 16، شماره 1، اردیبهشت 2026، صفحه 81-84    اصل مقاله (1.25 M)
نوع مقاله: Hypothesis
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2407-1791
نویسندگان
Mahsa Pakroo1؛ Seyed Ali Reza Mortazavi* 2؛ Seyed Mohammad Javad Mortazavi3، 4
1Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2MVLS College, The University of Glasgow, Glasgow, Scotland, United Kingdom
3Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
The microgravity environment and high radiation levels in space lead to a significant increase in Reactive Oxygen Species (ROS) production compared to Earth, which can have detrimental effects on astronaut health over time. This study examines the hypothesis that high levels of ROS in living organisms in space may aid pre-selected astronauts’ cells in adapting to the intense radiation encountered during missions to Mars and beyond. By looking at evolutionary biology and past radiation events like the Chernobyl disaster, we suggest that increased ROS could trigger adaptive responses similar to those seen in radiation-resistant organisms such as tardigrades. This paper explores the dual nature of ROS as both harmful agents and vital signaling molecules, evaluating their potential to enhance DNA repair, boost antioxidant defenses, and alter mitochondrial metabolism. We aim to see if managing ROS could be a strategy to prepare astronauts’ cells for space travel, using cytogenetic tests to find individuals with strong adaptive responses.

تازه های تحقیق

Seyed Mahammad Javad Mortazavi (Google Scholar)

کلیدواژه‌ها
Reactive Oxygen Species؛ Space؛ Astronauts؛ Adaptation؛ Radiation؛ Microgravity
مراجع
  1. Fornalski KW, Adamowski Ł, Dobrzyński L, Jarmakiewicz R, Powojska A, Reszczyńska J. The radiation adaptive response and priming dose influence: the quantification of the Raper-Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations. Radiat Environ Biophys. 2022;61(2):221-39. doi: 10.1007/s00411-022-00963-9. PubMed PMID: 35150289. PubMed PMCID: PMC9021059.
  2. Ghiassi-nejad M, Mortazavi SMJ, Cameron JR, Niroomand-rad A, Karam PA. Very high background radiation areas of Ramsar, Iran: preliminary biological studies. Health Phys. 2002;82(1):87-93. doi: 10.1097/00004032-200201000-00011. PubMed PMID: 11769138.
  3. Mortazavi SMJ, Cameron JR, Niroomand-rad A. Adaptive response studies may help choose astronauts for long-term space travel. Adv Space Res. 2003;31(6):1543-51. doi: 10.1016/s0273-1177(03)00089-9. PubMed PMID: 12971409.
  4. Mortazavi SMJ. Space radiobiology and the new era of induced radioresistance: should traditional concepts be moved to science history museums? Technol Health Care. 2013;21(4):285-9. doi: 10.3233/THC-130732. PubMed PMID: 23949175.
  5. Mortazavi SMJ, Said-Salman I, Mortazavi AR, El Khatib S, Sihver L. How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond. Front Microbiol. 2024;14:1237564. doi: 10.3389/fmicb.2023.1237564. PubMed PMID: 38390219. PubMed PMCID: PMC10881706.
  6. Bevelacqua JJ, Mortazavi SMJ. Commentary: Human Pathophysiological Adaptations to the Space Environment. Front Physiol. 2018;8:1116. doi: 10.3389/fphys.2017.01116. PubMed PMID: 29358922. PubMed PMCID: PMC5766677.
  7. Sihver L, Mortazavi SMJ. Biological Protection in Deep Space Missions. J Biomed Phys Eng. 2021;11(6):663-74. doi: 10.31661/jbpe.v0i0.1193. PubMed PMID: 34904063. PubMed PMCID: PMC8649166.1981;28:506-14. PubMed PMID: 7275131.
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