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Safarpour, Ali Reza, Shahedi, Alireza, Fattahi, Mohammad Reza, Sadeghi, Erfan, Akbarzadeh, Majid, Ahmadi, Lida, Nikmanesh, Nika, Fallahzadeh Abarghooee, Ebrahim, Shamsdin, Seyedeh Azra, Akrami, Hassan, Nikmanesh, Yousef. (1403). Epidemiology of Hepatitis D Virus and Associated Factors in Patients Referred to Level Three Hepatitis Clinic, Fars Province, Southern Iran. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2024.101949.3469
Ali Reza Safarpour; Alireza Shahedi; Mohammad Reza Fattahi; Erfan Sadeghi; Majid Akbarzadeh; Lida Ahmadi; Nika Nikmanesh; Ebrahim Fallahzadeh Abarghooee; Seyedeh Azra Shamsdin; Hassan Akrami; Yousef Nikmanesh. "Epidemiology of Hepatitis D Virus and Associated Factors in Patients Referred to Level Three Hepatitis Clinic, Fars Province, Southern Iran". سامانه مدیریت نشریات علمی, , , 1403, -. doi: 10.30476/ijms.2024.101949.3469
Safarpour, Ali Reza, Shahedi, Alireza, Fattahi, Mohammad Reza, Sadeghi, Erfan, Akbarzadeh, Majid, Ahmadi, Lida, Nikmanesh, Nika, Fallahzadeh Abarghooee, Ebrahim, Shamsdin, Seyedeh Azra, Akrami, Hassan, Nikmanesh, Yousef. (1403). 'Epidemiology of Hepatitis D Virus and Associated Factors in Patients Referred to Level Three Hepatitis Clinic, Fars Province, Southern Iran', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2024.101949.3469
Safarpour, Ali Reza, Shahedi, Alireza, Fattahi, Mohammad Reza, Sadeghi, Erfan, Akbarzadeh, Majid, Ahmadi, Lida, Nikmanesh, Nika, Fallahzadeh Abarghooee, Ebrahim, Shamsdin, Seyedeh Azra, Akrami, Hassan, Nikmanesh, Yousef. Epidemiology of Hepatitis D Virus and Associated Factors in Patients Referred to Level Three Hepatitis Clinic, Fars Province, Southern Iran. سامانه مدیریت نشریات علمی, 1403; (): -. doi: 10.30476/ijms.2024.101949.3469

Epidemiology of Hepatitis D Virus and Associated Factors in Patients Referred to Level Three Hepatitis Clinic, Fars Province, Southern Iran

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 29 دی 1403    اصل مقاله (314.18 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.101949.3469
نویسندگان
Ali Reza Safarpour1؛ Alireza Shahedi2؛ Mohammad Reza Fattahi1؛ Erfan Sadeghi3؛ Majid Akbarzadeh4؛ Lida Ahmadi1؛ Nika Nikmanesh1؛ Ebrahim Fallahzadeh Abarghooee5؛ Seyedeh Azra Shamsdin1؛ Hassan Akrami1؛ Yousef Nikmanesh* 1
1Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
3Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Hepatitis D is caused by the hepatitis D virus (HDV) and affects those who have already been infected with the hepatitis B virus (HBV). The epidemiology of hepatitis D in Fars Province, Iran, is poorly understood. This study aimed to investigate the epidemiology of HDV and its associated factors in patients attending Shahid Motahari Clinic, affiliated with Shiraz University of Medical Sciences (Shiraz, Iran).
Methods: This prospective cohort study was conducted in Shiraz, Iran, from 2001 to 2023. This study screened individuals with low HBV viral load and elevated liver enzymes for HDV. Pearson Chi square, Fisher’s exact, and Mann-Whitney U tests were used to examine the univariate associations between hepatitis D and various risk factors. Risk factors with P<0.2 were analyzed using multiple logistic regression to estimate odds ratios and 95% confidence intervals. P<0.05 was considered statistically significant.
Results: The variables were compared between the HDV+ (29) and HDV- (108). The variables of age (P=0.002) and using hookah (P=0.040) were statistically significant. The other variables examined in this study were not statistically significant. Increasing age (OR=1.06, 95% CI=[1.019, 1.102], P=0.003) was identified as a risk factor, while dental visits (OR=0.290 95% CI=[0.101, 0.836], P=0.022) were assessed as a protective factor.
Conclusion: Age was a significant risk factor for HDV infection, while a history of dental procedures appeared to be a protective factor. To better understand the epidemiology of HDV, further comprehensive research is necessary, focusing on diverse demographic groups in different regions.
کلیدواژه‌ها
Hepatitis D؛ Risk factors؛ Epidemiology؛ Iran
مراجع
  1. Odenwald MA, Paul S. Viral hepatitis: Past, present, and future. World J Gastroenterol. 2022;28:1405-29. doi: 10.3748/wjg.v28.i14.1405. PubMed PMID: 35582678; PubMed Central PMCID: PMCPMC9048475.
  2. Lee AU, Lee C. Hepatitis D Review: Challenges for the Resource-Poor Setting. Viruses. 2021;13. doi: 10.3390/v13101912. PubMed PMID: 34696341; PubMed Central PMCID: PMCPMC8538672.
  3. Li W, Urban S. Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications. J Hepatol. 2016;64:S32-S40. doi: 10.1016/j.jhep.2016.02.011. PubMed PMID: 27084034; PubMed Central PMCID: PMCPMC7114860.
  4. Sureau C, Negro F. The hepatitis delta virus: Replication and pathogenesis. J Hepatol. 2016;64:S102-S16. doi: 10.1016/j.jhep.2016.02.013. PubMed PMID: 27084031.
  5. Negro F. Hepatitis D virus coinfection and superinfection. Cold Spring Harb Perspect Med. 2014;4:a021550. doi: 10.1101/cshperspect.a021550. PubMed PMID: 25368018; PubMed Central PMCID: PMCPMC4208707.
  6. Patel EU, Thio CL, Boon D, Thomas DL, Tobian AAR. Prevalence of Hepatitis B and Hepatitis D Virus Infections in the United States, 2011-2016. Clin Infect Dis. 2019;69:709-12. doi: 10.1093/cid/ciz001. PubMed PMID: 30605508; PubMed Central PMCID: PMCPMC6669285.
  7. Dandri M, Volmari A, Lutgehetmann M. The hepatitis delta virus and chronic hepatitis D. J Hepatol. 2022;77:1448-50. doi: 10.1016/j.jhep.2022.05.022. PubMed PMID: 35850738.
  8. Taylor JM. Infection by Hepatitis Delta Virus. Viruses. 2020;12. doi: 10.3390/v12060648. PubMed PMID: 32560053; PubMed Central PMCID: PMCPMC7354607.
  9. Organization WH [Internet]. Hepatitis D. [cited 12 October 2023]. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-d
  10. Pisano MB, Giadans CG, Flichman DM, Re VE, Preciado MV, Valva P. Viral hepatitis update: Progress and perspectives. World J Gastroenterol. 2021;27:4018-44. doi: 10.3748/wjg.v27.i26.4018. PubMed PMID: 34326611; PubMed Central PMCID: PMCPMC8311538.
  11. Da BL, Rahman F, Lai WC, Kleiner DE, Heller T, Koh C. Risk Factors for Delta Hepatitis in a North American Cohort: Who Should Be Screened? Am J Gastroenterol. 2021;116:206-9. doi: 10.14309/ajg.0000000000000954. PubMed PMID: 33027083; PubMed Central PMCID: PMCPMC9205618.
  12. Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, et al. The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis. J Hepatol. 2020;73:523-32. doi: 10.1016/j.jhep.2020.04.008. PubMed PMID: 32335166; PubMed Central PMCID: PMCPMC7438974.
  13. Castaneda D, Gonzalez AJ, Alomari M, Tandon K, Zervos XB. From hepatitis A to E: A critical review of viral hepatitis. World J Gastroenterol. 2021;27:1691-715. doi: 10.3748/wjg.v27.i16.1691. PubMed PMID: 33967551; PubMed Central PMCID: PMCPMC8072198.
  14. Tahaei SM, Mohebbi SR, Azimzadeh P, Behelgardi A, Sanati A, Mohammadi P, et al. Prevalence of hepatitis D virus in hepatitis B virus infected patients referred to Taleghani hospital, Tehran, Iran. Gastroenterol Hepatol Bed Bench. 2014;7:144-50. PubMed PMID: 25120894; PubMed Central PMCID: PMCPMC4129564.
  15. Pouri AA, Ghojazadeh M, Baiaz B, Hamzavi FS, Pourasghari B, Somi MH. Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study. Health Promot Perspect. 2020;10:38-42. doi: 10.15171/hpp.2020.07. PubMed PMID: 32104655; PubMed Central PMCID: PMCPMC7036205.
  16. Sayad B, Naderi Y, Alavian SM, Najafi F, Janbakhsh A, Mansouri F, et al. Hepatitis D virus infection in Kermanshah, west of Iran: seroprevalence and viremic infections. Gastroenterol Hepatol Bed Bench. 2018;11:145-52. PubMed PMID: 29910856; PubMed Central PMCID: PMCPMC5990919.
  17. Torang T, Khanlepour M, Mohammadreza M, Hafez TGF, Iraj M, Khalilian A. Investigation of the prevalence of hepatitis D virus in HBs Ag positive patients and investigation of related factors in Sari city during 2015-2016 (short report). Journal of Mazandaran University of Medical Sciences. 2016;18:102-6. Persian.
  18. Makhlouf NA, Morsy KH, Mahmoud AA. Hepatitis D virus infection among hepatitis B virus surface antigen positive individuals in Upper Egypt: Prevalence and clinical features. J Infect Public Health. 2019;12:350-6. doi: 10.1016/j.jiph.2018.12.001. PubMed PMID: 30833193.
  19. Zi J, Li YH, Wang XM, Xu HQ, Liu WH, Cui JY, et al. Hepatitis D virus dual-infection among Chinese hepatitis B patient related to hepatitis B surface antigen, hepatitis B virus DNA and age. World J Gastroenterol. 2023;29:5395-405. doi: 10.3748/wjg.v29.i38.5395. PubMed PMID: 37900584; PubMed Central PMCID: PMCPMC10600800.
  20. Okonkwo UC, Okpara HC, Inaku K, Aluka TM, Chukwudike ES, Ogarekpe Y, et al. Prevalence and risk factors of Hepatitis D virus antibody among asymptomatic carriers of Hepatitis B virus: a community survey. Afr Health Sci. 2022;22:504-10. doi: 10.4314/ahs.v22i1.59. PubMed PMID: 36032492; PubMed Central PMCID: PMCPMC9382513.
  21. Rink L, Wessels I. Immunosenescence. In: Rezaei N, editor. Encyclopedia of Infection and Immunity. Oxford: Elsevier; 2022. p. 259-76.
  22. Ziaee M, Azarkar G. Prevalence of hepatitis d virus infection among patients with chronic hepatitis B attending birjand hepatitis clinic (East of iran) in 2012. Hepat Mon. 2013;13:e11168. doi: 10.5812/hepatmon.11168. PubMed PMID: 24171009; PubMed Central PMCID: PMCPMC3800676.
  23. Su CW, Ochirkhuree B, Namdag B, Badamnachin B, Ganbold S, Gidaagaya S, et al. Risk factors associated with hepatitis D virus infection and preventive strategies in Mongolia. J Chin Med Assoc. 2024;87:480-7. doi: 10.1097/JCMA.0000000000001073. PubMed PMID: 38417133.
  24. Wang J, Geng L. Effects of Socioeconomic Status on Physical and Psychological Health: Lifestyle as a Mediator. Int J Environ Res Public Health. 2019;16. doi: 10.3390/ijerph16020281. PubMed PMID: 30669511; PubMed Central PMCID: PMCPMC6352250.
  25. Najafi E, Amini-Rarani M, Moeeni M. Inequality in dental care expenditure in Iranian households: analysis of income quintiles and educational levels. BMC Oral Health. 2021;21:550. doi: 10.1186/s12903-021-01912-6. PubMed PMID: 34702242; PubMed Central PMCID: PMCPMC8549140.
  26. Osiowy C, Swidinsky K, Haylock-Jacobs S, Sadler MD, Fung S, Wong D, et al. Molecular epidemiology and clinical characteristics of hepatitis D virus infection in Canada. JHEP Rep. 2022;4:100461. doi: 10.1016/j.jhepr.2022.100461. PubMed PMID: 35360523; PubMed Central PMCID: PMCPMC8961228.
  27. Klein SL, Morgan R. The impact of sex and gender on immunotherapy outcomes. Biol Sex Differ. 2020;11:24. doi: 10.1186/s13293-020-00301-y. PubMed PMID: 32366281; PubMed Central PMCID: PMCPMC7197158.
  28. Daw MA, Daw AM, Sifennasr NEM, Draha A, Daw A, Daw A, et al. The epidemiological characterization and geographic distribution of hepatitis D virus infection in Libya. Pan Afr Med J. 2020;35:120. doi: 10.11604/pamj.2020.35.120.20055. PubMed PMID: 32637018; PubMed Central PMCID: PMCPMC7320781.
  29. Kpossou AR, Sogbo F, Zomahoun AMO, Alassan KS, Vignon RK, Sokpon CNdM, et al. Hepatitis D in patients infected with Hepatitis B Virus in cotonou: Characteristics and risk factors. Open Journal of Gastroenterology. 2020;10:31-44. doi: 10.4236/ojgas.2020.102004.
  30. Chin B, Murphy MLM, Janicki-Deverts D, Cohen S. Marital status as a predictor of diurnal salivary cortisol levels and slopes in a community sample of healthy adults. Psychoneuroendocrinology. 2017;78:68-75. doi: 10.1016/j.psyneuen.2017.01.016. PubMed PMID: 28171850; PubMed Central PMCID: PMCPMC5365082.
  31. Salvatore JE, Gardner CO, Kendler KS. Marriage and reductions in men’s alcohol, tobacco, and cannabis use. Psychol Med. 2020;50:2634-40. doi: 10.1017/S0033291719002964. PubMed PMID: 31685061; PubMed Central PMCID: PMCPMC7198324.
  32. Schoeppe S, Vandelanotte C, Rebar AL, Hayman M, Duncan MJ, Alley SJ. Do singles or couples live healthier lifestyles? Trends in Queensland between 2005-2014. PLoS One. 2018;13:e0192584. doi: 10.1371/journal.pone.0192584. PubMed PMID: 29489832; PubMed Central PMCID: PMCPMC5830314.
  33. Dambadarjaa D, Mukhtar Y, Tsogzolbaatar EO, Khuyag SO, Dayan A, Oyunbileg NE, et al. Hepatitis B, C, and D Virus Infections and AFP Tumor Marker Prevalence Among the Elderly Population in Mongolia: A Nationwide Survey. J Prev Med Public Health. 2022;55:263-72. doi: 10.3961/jpmph.21.573. PubMed PMID: 35678000; PubMed Central PMCID: PMCPMC9201085.
  34. Rizzetto M. Hepatitis D Virus: Introduction and Epidemiology. Cold Spring Harb Perspect Med. 2015;5:a021576. doi: 10.1101/cshperspect.a021576. PubMed PMID: 26134842; PubMed Central PMCID: PMCPMC4484953.
  35. Chen HY, Shen DT, Ji DZ, Han PC, Zhang WM, Ma JF, et al. Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis. Gut. 2019;68:512-21. doi: 10.1136/gutjnl-2018-316601. PubMed PMID: 30228220.
  36. Battah KA, Badranc DH, Shraideh ZA. Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study. International Journal of Morphology. 2016;34. doi: 10.4067/S0717-95022016000400011.
  37. Wen J, Zhou Y, Wang J, Chen J, Yan W, Wu J, et al. Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-gamma/STAT1 pathway. Cell Death Differ. 2017;24:997-1006. doi: 10.1038/cdd.2017.31. PubMed PMID: 28304404; PubMed Central PMCID: PMCPMC5442468.
  38. Rutledge SM, Asgharpour A. Smoking and Liver Disease. Gastroenterol Hepatol (N Y). 2020;16:617-25. PubMed PMID: 34035697; PubMed Central PMCID: PMCPMC8132692.
  39. Mahmoudzadeh L, Abtahi Froushani SM, Ajami M, Mahmoudzadeh M. Effect of Nicotine on Immune System Function. Adv Pharm Bull. 2023;13:69-78. doi: 10.34172/apb.2023.008. PubMed PMID: 36721811; PubMed Central PMCID: PMCPMC9871277.
  40. Qiu F, Liang CL, Liu H, Zeng YQ, Hou S, Huang S, et al. Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? Oncotarget. 2017;8:268-84. doi: 10.18632/oncotarget.13613. PubMed PMID: 27902485; PubMed Central PMCID: PMCPMC5352117.
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