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Concerns Regarding the Efficacy of Utilizing the Vibrational Response of Aminocyanine Molecules to Near Infrared Light for Cancer Cell Destruction | ||
| Journal of Biomedical Physics and Engineering | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 09 دی 1403 اصل مقاله (353.46 K) | ||
| نوع مقاله: Commentary | ||
| نویسندگان | ||
| Parsa Faghani-Eskandarkolaei1؛ James Welsh2، 3؛ Seyed Ali Reza Mortazavi4؛ Parmis Taghizadeh5؛ Mobina Baramaki5؛ Fatemeh Shams5؛ Mohammed Nasir Abubakari6؛ Seyed Mohammad Javad Mortazavi* 1، 7؛ Lembit Sihver* 8، 9، 10 | ||
| 1Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Radiation Oncology, Stritch School of Medicine Loyola University Chicago, Maywood, IL, USA | ||
| 3Department of Radiation Oncology, Edward Hines Jr Veterans Affairs Hospital, Maywood, Illinois, USA | ||
| 4MVLS College, The University of Glasgow, Glasgow, Scotland, United Kingdom | ||
| 5Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Department of Medical Imaging, School of Allied health Sciences, University for Development Studies, Ghana | ||
| 7Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Department of Informatics & Engineering Systems, The University of Texas Rio Grande Valley, Brownsville, TX, USA | ||
| 9Department of Physics, the Harriot College of Art and Sciences East Carolina University, Greenville, NC, USA. | ||
| 10Royal Military College of Canada, Kingston, ON, Canada | ||
| چکیده | ||
| Recent advancements in cancer treatment have introduced the use of aminocyanine molecules, activated by near-infrared (NIR) light, to induce vibrational responses that can selectively destroy cancer cells. This commentary critically examines a study that reports a 99% efficacy of this method against human melanoma cells in vitro, and significant tumor reduction in murine models. While the findings are promising, our analysis highlights crucial oversights in the study’s implications for clinical applications. Specifically, the persistence of even a small fraction of cancer cells post-treatment poses significant risks for tumor regrowth and acquired resistance. Additionally, the study’s approach neglects the heterogeneity of cancer cells and the presence of cancer stem cells, which are known to contribute to recurrence and resistance. We also discuss the limitations of the Tumor Control Probability (TCP) model in predicting treatment outcomes, emphasizing that achieving near-total eradication of cancer cells is necessary to prevent recurrence. Our commentary underscores the need for comprehensive research to address these challenges and ensure the efficacy and safety of novel cancer treatments utilizing aminocyanine molecules and NIR light. | ||
| کلیدواژه‌ها | ||
| Cancer؛ Near Infrared؛ Aminocyanine؛ Vibration؛ Antineoplastic Protocols؛ Radiotherapy | ||
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آمار تعداد مشاهده مقاله: 58 تعداد دریافت فایل اصل مقاله: 39 |
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