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Elwan, Amira, Bakry, Adel, Elwan, Ahmed. (1403). Gefitinib Combination with Radiotherapy in Patients with Local Advanced Non-Small Cell Lung Cancer. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2024.103982.2161
Amira Elwan; Adel Bakry; Ahmed Elwan. "Gefitinib Combination with Radiotherapy in Patients with Local Advanced Non-Small Cell Lung Cancer". سامانه مدیریت نشریات علمی, , , 1403, -. doi: 10.30476/mejc.2024.103982.2161
Elwan, Amira, Bakry, Adel, Elwan, Ahmed. (1403). 'Gefitinib Combination with Radiotherapy in Patients with Local Advanced Non-Small Cell Lung Cancer', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2024.103982.2161
Elwan, Amira, Bakry, Adel, Elwan, Ahmed. Gefitinib Combination with Radiotherapy in Patients with Local Advanced Non-Small Cell Lung Cancer. سامانه مدیریت نشریات علمی, 1403; (): -. doi: 10.30476/mejc.2024.103982.2161

Gefitinib Combination with Radiotherapy in Patients with Local Advanced Non-Small Cell Lung Cancer

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 دی 1403    اصل مقاله (464.35 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2024.103982.2161
نویسندگان
Amira Elwan* 1؛ Adel Bakry2؛ Ahmed Elwan3
1Clinical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Cardiothoracic Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
چکیده
Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors is a crucial agent in EGFR-mutated advanced lung disease. Previous studies have suggested a positive correlation between EGFR overexpression and cellular radioresistance in the treatment of non-small cell lung cancer (NSCLC). Concurrent or sequential Gefitinib with thoracic irradiation showed tolerability and possible efficacy in patients who exhibited EGFR mutation. The aim of this study was to improve treatment outcomes of local advanced NSCLC patients.
Method: A prospective study included stage III NSCLC cases divided in to 30 patients in Arm A and 20 patients B. The patients received thoracic irradiation concurrently or sequentially with Gefitinib. We used Kaplan-Meier plot and compared results using log-rank test. Percent of categorical variables were compared using Pearson’s chi-square test or Fisher’s exact test when appropriate. A P-value of less than 0.05 was considered to be statistically significant using SPSS 16.0.
Results: Pneumonitis was more observed toxicity in Arm A versus Arm B with statistical significance P = 0.039. The median progression-free survival was 10 months with a 95 % confidence interval range of 8.2-11.7 months, 8.5-11.4 months in Arm A and Arm B, respectively. The median overall survival was 18 months versus 16 months with the range at 95 % confidence interval of 12.6-23.3 months versus 13.2-18.7 months in Arm A and Arm B, respectively.
Conclusion: Gefitinib is affordable and effective with thoracic irradiation in NSCLC patients with accepted toxicity profile. 

تازه های تحقیق

Amira Elwan (Google Scholar)

کلیدواژه‌ها
Carcinoma؛ Non-small-cell lung؛ Mutation؛ Gefitinib؛ Pneumonitis
مراجع
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