پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,157 |
| تعداد مقالات | 10,573 |
| تعداد مشاهده مقاله | 45,916,283 |
| تعداد دریافت فایل اصل مقاله | 11,583,793 |
Analysis of the Blood Levels of NK and NKT Cells in Patients with Severe SARS-CoV-2 Infection | ||
| Iranian Journal of Immunology | ||
| دوره 21، شماره 4، اسفند 2024، صفحه 340-352 اصل مقاله (2.27 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2024.100817.2710 | ||
| نویسندگان | ||
| Marlen Vitales-Noyola1، 2؛ Diana Lorena Alvarado-Hernández3؛ Raquel Sánchez-Gutiérrez4؛ Berenice Hernández-Castro3؛ Larisa González-Baranda5؛ Sofía Bernal-Siva6؛ Andreu Comas-García6؛ Carmen Sánchez-Torres2؛ Roberto González-Amaro* 1، 3 | ||
| 1Endodontics Postgraduate Program, Faculty of Dentistry, Autonomous University of San Luis Potosi, San Luis Potosí, México. | ||
| 2Department of Molecular Biomedicine, Centro de Investigación y Estudios Avanzados, IPN, Mexico City, México. | ||
| 3Department of Immunology, School of Medicine, Autonomous University of San Luis Potosi, San Luis Potosí, México. | ||
| 4Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA. | ||
| 5Internal Medicine Division. Central Hospital Dr. Ignacio Morones Prieto. San Luis Potosi, S.L.P.Mexico | ||
| 6Department of Microbiology, School of Medicine, Autonomous University of San Luis Potosi, SLP, Mexico | ||
| چکیده | ||
| Background: Clinical manifestations SARS-CoV-2 infection are variable, ranging from asymptomatic to pneumonia, and different serious complications. It has been observed that some populations exhibit an enhanced risk for severe disease and death, compared to other ethnical groups. Objective: To evaluate two parameters of the innate immune system, which have a relevant role in viral immunity. Methods: In samples of peripheral blood from sixteen patients with severe COVID-19, ten with asymptomatic-mild disease, and fifteen healthy controls, the numbers of NK and NKT cells, the expression of different NK cell receptors and the serum levels of pro-inflammatory cytokines were analyzed. Results: We found that patients with severe COVID-19 showed significant lower levels of both CD56dim and CD56bright NK cells compared to patients with mild disease or healthy subjects. Furthermore, an abnormal expression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 was observed in severe COVID-19 patients. Likewise, NK cells from these patients also showed significant differences in the expression of several killer immunoglobulin-like receptors (KIR’s), in the two main cell subsets (CD56bright, CD56dim), compared to controls or patients with mild disease. Moreover, patients with severe COVID-19 showed lower levels of NKT cells (defined as CD3+CD56+) and increased serum concentrations of IL-6 and IL-8. Conclusion: We consider that the abnormalities in NK and NKT cells observed in patients with severe COVID-19 might have a relevant role in the outcome of this infection in some population groups. | ||
| کلیدواژه‌ها | ||
| COVID-19؛ NK cells؛ NKT Cells؛ SARS-CoV-2؛ Membrane Receptors | ||
|
آمار تعداد مشاهده مقاله: 301 تعداد دریافت فایل اصل مقاله: 218 |
||