LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,183
تعداد مقالات10,793
تعداد مشاهده مقاله72,655,053
تعداد دریافت فایل اصل مقاله12,778,328
Rahman, Amtul, Banu, Zeenath. (1403). Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease. سامانه مدیریت نشریات علمی, 10(4), 355-366. doi: 10.30476/tips.2024.103641.1253
Amtul Rahman; Zeenath Banu. "Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease". سامانه مدیریت نشریات علمی, 10, 4, 1403, 355-366. doi: 10.30476/tips.2024.103641.1253
Rahman, Amtul, Banu, Zeenath. (1403). 'Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease', سامانه مدیریت نشریات علمی, 10(4), pp. 355-366. doi: 10.30476/tips.2024.103641.1253
Rahman, Amtul, Banu, Zeenath. Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease. سامانه مدیریت نشریات علمی, 1403; 10(4): 355-366. doi: 10.30476/tips.2024.103641.1253

Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease

Trends in Pharmaceutical Sciences
مقاله 8، دوره 10، شماره 4، اسفند 2024، صفحه 355-366    اصل مقاله (463.49 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/tips.2024.103641.1253
نویسندگان
Amtul Rahman؛ Zeenath Banu*
Department of Pharmacology, RBVRR Women’s College of Pharmacy, Affiliated to Osmania University, Barkathpura, Hyderabad, India
چکیده
Aluminium chloride (AlCl3) is a prevalent environmental pollutant found in food and drinking water. Epidemiological studies suggest a strong link between AlCl3 exposure and neurodegenerative disorders, especially Alzheimer’s disease (AD). AlCl3 disrupts normal brain function, potentially leading to oxidative stress, inflammatory responses, and cognitive decline, all of which are implicated in AD pathology. This review compiled and analysed data from 59 studies, accessed through academic databases such as Google Scholar, PubMed, Springer, Science Direct, Wiley, Scopus, and Research Gate. The focus was specifically on the neurotoxic effects of AlCl₃, drawing insights into its impact on brain structure, function, and behaviour. Findings from the reviewed studies reveal that AlCl3 exposure leads to increased aluminium accumulation in brain tissues, resulting in structural damage and neurotoxic effects. This accumulation affects cognitive functions and behaviour, with histological analyses showing signs of neurodegeneration. Behavioural changes and impaired cognitive abilities observed in animal and cellular models suggest that AlCl3 disrupts neural pathways critical to learning and memory. The evidence indicates a significant association between AlCl3 exposure and neurodegenerative damage, especially in the context of AD. This review emphasizes the need for further research into AlCl3's neurotoxic mechanisms to clarify its role in AD and other neurodegenerative diseases. Enhanced understanding may help develop preventive measures and regulations to mitigate the health risks posed by aluminium exposure in daily life.

تازه های تحقیق

Amtul Rahman (Google Scholar)

Zeenath Banu (Google Scholar)

کلیدواژه‌ها
Aluminium chloride؛ Alzheimer’s disease؛ Neurotoxicity؛ Oxidative stress؛ Cognitive impairment
مراجع
1.    European Food Safety Authority (EFSA). Safety of aluminium from dietary intake - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC). EFSA J. 2008 Jul 15;6(7):754. doi: 10.2903/j.efsa.2008.754. PMID: 37213837; PMCID: PMC10193631.
2.    Terry RD, Pena C. Experimental production of neurofibrillary degeneration. J Neuropath Exp Neurol. 1965;24:200-10. doi: 10.1097/00005072-196504000-00003. PMID: 14280497.
3.    Cheraghi E, Roshanaei K. The protective effect of curcumin against aluminium chloride-induced oxidative stress and hepatotoxicity in rats. : Pharm Biomed Res. 2019;5(1): 11-18.
4.    Maksoud HA, Said AM, Abdeldaiem MA, Hassan MA. Aluminum chloride induced inflammatory process in rat’s brain. SchInt J Biochem. 2020;3(10):1-4.
5.    Yuan CY, Lee YJ, Hsu GS. Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats. J Biomed Sci. 2012 May 21;19(1):51. doi: 10.1186/1423-0127-19-51. PMID: 22613782; PMCID: PMC3404950.
6.    Rui D, Yongjian Y. Aluminum chloride induced oxidative damage on cells derived from hippocampus and cortex of ICR mice. Brain Res. 2010 Apr 9;1324:96-102. doi: 10.1016/j.brainres.2010.02.024. Epub 2010 Feb 12. PMID: 20156420.
7.    Nirmala Rajesh Naidu N, Shankar Bhat S, Urban Dsouza U. Effect of long-term administration of aluminium chloride on oxidative stress and acetylcholinesterase activity in rat brains. Int J Pharm Biol Sci. 2013;3(1):616–22.
8.    Li S, Zhang Q, Ding Y, Wang X, Liu P. Flavonoids ameliorate aluminum chloride-induced learning and memory impairments via suppression of apoptosis and oxidative stress in rats. J Inorg Biochem. 2020 Nov;212:111252. doi: 10.1016/j.jinorgbio.2020.111252. Epub 2020 Sep 13. PMID: 32950828.
9.    Yilgor A, Demir C. Determination of oxidative stress level and some antioxidant activities in refractory epilepsy patients. Sci Rep. 2024 Mar 20;14(1):6688. doi: 10.1038/s41598-024-57224-6. PMID: 38509121; PMCID: PMC10954705.
10.    Tekin S, Seven E. Assessment of serum catalase, reduced glutathione, and superoxide dismutase activities and malondialdehyde levels in keratoconus patients. Eye (Lond). 2022 Oct;36(10):2062-2066. doi: 10.1038/s41433-021-01753-1. Epub 2021 Aug 30. PMID: 34462580; PMCID: PMC9499963.
11.    Strycharz-Dudziak M, Fołtyn S, Dworzański J, Kiełczykowska M, Malm M, Drop B, et al. Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in Oropharyngeal Cancer Associated with EBV and HPV Coinfection. Viruses. 2020 Sep 9;12(9):1008. doi: 10.3390/v12091008. PMID: 32917014; PMCID: PMC7551554.
12.    Cand F, Verdetti J. Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats. Free Radic Biol Med. 1989;7(1):59-63. doi: 10.1016/0891-5849(89)90101-9. PMID: 2753396.
13.    Gusti AMT, Qusti SY, Alshammari EM, Toraih EA, Fawzy MS. Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study. Antioxidants (Basel). 2021 Apr 13;10(4):595. doi: 10.3390/antiox10040595. PMID: 33924357; PMCID: PMC8070436.
14.    Bekhedda H, Menadi N, Demmouche A, Ghani A, Mai H. Histological study of the effects of aluminium chloride exposure on the brain of Wistar rats female. J Drug Deliv Ther. 2020;10(3-s):37-42.
15.    Buraimoh AA, Ojo SA, Hambolu JO, Adebisi SS. Effects of aluminium chloride exposure on the histology of the cerebral cortex of adult Wistar rats. J Biol Life Sci. 2012 Mar 5;3(1).
16.    Jadhav R, Kulkarni YA. Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats. Frontiers in Pharmacology. 2023 Feb 22;14:1034620.
17.    Zhao Y, Dang M, Zhang W, Lei Y, Ramesh T, Veeraraghavan VP, Hou X. Neuroprotective effects of Syringic acid against aluminium chloride induced oxidative stress mediated neuroinflammation in rat model of Alzheimer's disease. J Funct Foods. 2020 Aug 1;71:104009.
18.    Morris G, Puri BK, Frye RE. The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?. Metab Brain Dis. 2017 Oct;32(5):1335-55.
19.    Farasani A, Darbre PD. Effects of aluminium chloride and aluminium chlorohydrate on DNA repair in MCF10A immortalised non-transformed human breast epithelial cells. J Inorg Biochem. 2015 Nov;152:186-9. doi: 10.1016/j.jinorgbio.2015.08.003. Epub 2015 Aug 15. PMID: 26319584.
20.    Chavan P, Danane T, Sharbidre A, Pawar S, Jadhav A, Jagtap S. Diosgenin Mitigates Aluminum Chloride Mediated Developmental Toxicity in Drosophila melanogaster. Toxicol Int. 2024 Apr 8;31(2):169-80.
21.    Bhattacharjee B, Ali A, Tuteja N, Gill S, Pattanayak A. Identification and expression pattern of aluminium-responsive genes in roots of rice genotype with reference to Al-sensitivity. Sci Rep. 2023 Jul 27;13(1):12184. doi: 10.1038/s41598-023-39238-8. PMID: 37500702; PMCID: PMC10374657.
22.    Liaquat L, Sadir S, Batool Z, Tabassum S, Shahzad S, Afzal A, et al. Acute aluminum chloride toxicity revisited: Study on DNA damage and histopathological, biochemical and neurochemical alterations in rat brain. Life Sci. 2019 Jan 15;217:202-211. doi: 10.1016/j.lfs.2018.12.009. Epub 2018 Dec 5. PMID: 30528774.
23.    Skalny AV, Aschner M, Jiang Y, Gluhcheva YG, Tizabi Y, Lobinski R, Tinkov AA. Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. Adv Neurotoxicol. 2021;5:1-34. doi: 10.1016/bs.ant.2020.12.001. Epub 2021 Feb 11. PMID: 34263089; PMCID: PMC8276946.
24.    Borai IH, Ezz MK, Rizk MZ, Aly HF, El-Sherbiny M, Matloub AA, et al. Therapeutic impact of grape leaves polyphenols on certain biochemical and neurological markers in AlCl3-induced Alzheimer's disease. Biomed Pharmacother. 2017 Sep;93:837-851. doi: 10.1016/j.biopha.2017.07.038. Epub 2017 Jul 14. PMID: 28715867.
25.    Banks WA, Kastin AJ. Aluminum-induced neurotoxicity: alterations in membrane function at the blood-brain barrier. Neurosci Biobehav Rev. 1989 Spring;13(1):47-53. doi: 10.1016/s0149-7634(89)80051-x. PMID: 2671833.
26.    Irnidayanti Y, Aprilyanti RE. Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster). Berkala Penelitian Hayati. 2021 Apr 4;26(2):66-71. 
27.    Kandimalla R, Vallamkondu J, Corgiat EB, Gill KD. Understanding Aspects of Aluminum Exposure in Alzheimer's Disease Development. Brain Pathol. 2016 Mar;26(2):139-54. doi: 10.1111/bpa.12333. Epub 2015 Dec 8. PMID: 26494454; PMCID: PMC8028870.
28.    Chen X, Zhang M, Ahmed M, Surapaneni KM, Veeraraghavan VP, Arulselvan P. Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer's disease in rats. Saudi J Biol Sci. 2021 Aug;28(8):4232-4239. doi: 10.1016/j.sjbs.2021.06.031. Epub 2021 Jun 15. PMID: 34354404; PMCID: PMC8325004.
29.    Cao Z, Wang F, Xiu C, Zhang J, Li Y. Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in Aluminum chloride-induced Alzheimer's disease rats. Biomed Pharmacother. 2017 Jul;91:931-937. doi: 10.1016/j.biopha.2017.05.022. Epub 2017 May 13. PMID: 28514831.
30.    Adelodun ST, Ishola OA, Abijo AZ, Olatunji SY, Owolabi J, Olanrewaju JA et al. Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract. Phytomedicine Plus. 2021;1(4):100104. doi: 10.1016/j.phyplu.2021.100104
31.    Al-Hazmi MA, Rawi SM, Hamza RZ. Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats. Metab Brain Dis. 2021 Mar;36(3):429-436. doi: 10.1007/s11011-020-00664-6. Epub 2021 Jan 6. PMID: 33404936.
32.    Abbas F, Eladl MA, El-Sherbiny M, Abozied N, Nabil A, Mahmoud SM, et al. Celastrol and thymoquinone alleviate aluminum chloride-induced neurotoxicity: Behavioral psychomotor performance, neurotransmitter level, oxidative-inflammatory markers, and BDNF expression in rat brain. Biomed Pharmacother. 2022 Jul;151:113072. doi: 10.1016/j.biopha.2022.113072. Epub 2022 May 13. PMID: 35576663.
33.    Bhalla P, Dhawan DK. Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain. Cell Mol Neurobiol. 2009 Jun;29(4):513-21. doi: 10.1007/s10571-008-9343-5. Epub 2009 Jan 29. PMID: 19184412.
34.    Nayak P, Sharma SB, Chowdary NV. Augmentation of aluminum-induced oxidative stress in rat cerebrum by presence of pro-oxidant (graded doses of ethanol) exposure. Neurochem Res. 2010 Nov;35(11):1681-90. doi: 10.1007/s11064-010-0230-3. Epub 2010 Jul 18. PMID: 20640917.
35.    Ojha PS, Biradar PR, Tubachi S, Patil VS. Evaluation of neuroprotective effects of Canna indica L against aluminium chloride induced memory impairment in rats. Adv Trad Med. 2022;7:1-8.
36.    Hawash ZAS, Yassien EM, Alotaibi BS, El-Moslemany AM, Shukry M. Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl3 Toxicity in Rats. Toxics. 2023 Jun 6;11(6):509. doi: 10.3390/toxics11060509. PMID: 37368609; PMCID: PMC10305215.
37.    Elfiky AM, Mahmoud AA, Elreedy HA, Ibrahim KS, Ghazy MA. Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat model. Life Sci. 2021 Nov 15;285:119964. doi: 10.1016/j.lfs.2021.119964. Epub 2021 Sep 16. PMID: 34537230.
38.    Chen SJ, Lu JH, Lin CC, Zeng SW, Chang JF, Chung YC, et al. Synergistic Chemopreventive Effects of a Novel Combined Plant Extract Comprising Gallic Acid and Hesperidin on Colorectal Cancer. Curr Issues Mol Biol. 2023 Jun 5;45(6):4908-4922. doi: 10.3390/cimb45060312. PMID: 37367061; PMCID: PMC10297232.
39.    Lakshmi BV, Sudhakar M, Prakash KS. Protective effect of selenium against aluminum chloride-induced Alzheimer's disease: behavioral and biochemical alterations in rats. Biol Trace Elem Res. 2015 May;165(1):67-74. doi: 10.1007/s12011-015-0229-3. Epub 2015 Jan 23. PMID: 25613582.
40.    Shunan D, Yu M, Guan H, Zhou Y. Neuroprotective effect of Betalain against AlCl3-induced Alzheimer's disease in Sprague Dawley Rats via putative modulation of oxidative stress and nuclear factor kappa B (NF-κB) signaling pathway. Biomed Pharmacother. 2021 May;137:111369. doi: 10.1016/j.biopha.2021.111369. Epub 2021 Feb 12. PMID: 33582452.
41.    Mohamed SM, Shalaby MA, Al-Mokaddem AK, El-Banna AH, El-Banna HA, Nabil G. Evaluation of anti-Alzheimer activity of Echinacea purpurea extracts in aluminum chloride-induced neurotoxicity in rat model. J Chem Neuroanat. 2023 Mar;128:102234. doi: 10.1016/j.jchemneu.2023.102234. Epub 2023 Jan 11. PMID: 36640914.
42.    Liu Y, Meng X, Sun L, Pei K, Chen L, Zhang S, et al. Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl3-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways. Eur J Pharmacol. 2022 Jan 5;914:174691. doi: 10.1016/j.ejphar.2021.174691. Epub 2021 Dec 8. PMID: 34896111.
43.    Ravi SK, Ramesh BN, Mundugaru R, Vincent B. Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer's disease. Environ Toxicol Pharmacol. 2018 Mar;58:202-211. doi: 10.1016/j.etap.2018.01.008. Epub 2018 Jan 31. PMID: 29408763.
44.    Khalifa M, Safar MM, Abdelsalam RM, Zaki HF. Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats. Neurotox Res. 2020 Feb;37(2):275-285. doi: 10.1007/s12640-019-00085-z. Epub 2019 Jul 22. PMID: 31332715.
45.    Doungue HT, Kengne AP, Kuate D. Neuroprotective effect and antioxidant activity of Passiflora edulis fruit flavonoid fraction, aqueous extract, and juice in aluminum chloride-induced Alzheimer’s disease rats. Nutrire. 2018;43:1-2.
46.    Chavali VD, Agarwal M, Vyas VK, Saxena B. Neuroprotective Effects of Ethyl Pyruvate against Aluminum Chloride-Induced Alzheimer's Disease in Rats via Inhibiting Toll-Like Receptor 4. J Mol Neurosci. 2020 Jun;70(6):836-850. doi: 10.1007/s12031-020-01489-9. Epub 2020 Feb 6. PMID: 32030557.
47.    Abdel-Aal RA, Hussein OA, Elsaady RG, Abdelzaher LA. Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism. Eur J Pharmacol. 2022 Jan 15;915:174695. doi: 10.1016/j.ejphar.2021.174695. Epub 2021 Dec 14. PMID: 34914971.
48.    Justin Thenmozhi A, Raja TR, Janakiraman U, Manivasagam T. Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in Wistar rats. Neurochem Res. 2015 Apr;40(4):767-76. doi: 10.1007/s11064-015-1525-1. Epub 2015 Jan 29. Retraction in: Neurochem Res. 2024 Nov;49(11):3179. doi: 10.1007/s11064-024-04232-7. Erratum in: Neurochem Res. 2015 Sep;40(9):2006. doi: 10.1007/s11064-015-1689-8. Erratum in: Neurochem Res. 2022 Jul;47(7):2126-2127. doi: 10.1007/s11064-022-03616-x. PMID: 25630717.
49.    He X, Yan C, Zhao S, Zhao Y, Huang R, Li Y. The preventive effects of probiotic Akkermansia muciniphila on D-galactose/AlCl3 mediated Alzheimer's disease-like rats. Exp Gerontol. 2022 Dec;170:111959. doi: 10.1016/j.exger.2022.111959. Epub 2022 Sep 21. PMID: 36152776.

آمار
تعداد مشاهده مقاله: 9,608
تعداد دریافت فایل اصل مقاله: 166


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب