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Dehghanpisheh, Laleh, Jamshidi, Fatane, Khademi, Saeid, Farokhiani, Shirin, Cheraghi, Mohammad Reza, Emadi, Mahsa, Kaboodkhani, Reza, Akbari, Ali, Asmarian, Naeimehossadat, Banifatemi, Mahsa. (1404). Effect of a Single Preventive Intravenous Dose of Ketorolac and Paracetamol on Reducing Postoperative Pain in Septorhinoplasty Patients: Double-Blind Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 50(4), 239-246. doi: 10.30476/ijms.2024.102131.3488
Laleh Dehghanpisheh; Fatane Jamshidi; Saeid Khademi; Shirin Farokhiani; Mohammad Reza Cheraghi; Mahsa Emadi; Reza Kaboodkhani; Ali Akbari; Naeimehossadat Asmarian; Mahsa Banifatemi. "Effect of a Single Preventive Intravenous Dose of Ketorolac and Paracetamol on Reducing Postoperative Pain in Septorhinoplasty Patients: Double-Blind Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 50, 4, 1404, 239-246. doi: 10.30476/ijms.2024.102131.3488
Dehghanpisheh, Laleh, Jamshidi, Fatane, Khademi, Saeid, Farokhiani, Shirin, Cheraghi, Mohammad Reza, Emadi, Mahsa, Kaboodkhani, Reza, Akbari, Ali, Asmarian, Naeimehossadat, Banifatemi, Mahsa. (1404). 'Effect of a Single Preventive Intravenous Dose of Ketorolac and Paracetamol on Reducing Postoperative Pain in Septorhinoplasty Patients: Double-Blind Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 50(4), pp. 239-246. doi: 10.30476/ijms.2024.102131.3488
Dehghanpisheh, Laleh, Jamshidi, Fatane, Khademi, Saeid, Farokhiani, Shirin, Cheraghi, Mohammad Reza, Emadi, Mahsa, Kaboodkhani, Reza, Akbari, Ali, Asmarian, Naeimehossadat, Banifatemi, Mahsa. Effect of a Single Preventive Intravenous Dose of Ketorolac and Paracetamol on Reducing Postoperative Pain in Septorhinoplasty Patients: Double-Blind Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1404; 50(4): 239-246. doi: 10.30476/ijms.2024.102131.3488

Effect of a Single Preventive Intravenous Dose of Ketorolac and Paracetamol on Reducing Postoperative Pain in Septorhinoplasty Patients: Double-Blind Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 4، دوره 50، شماره 4، تیر 2025، صفحه 239-246    اصل مقاله (293.94 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.102131.3488
نویسندگان
Laleh Dehghanpisheh1؛ Fatane Jamshidi* 1؛ Saeid Khademi1؛ Shirin Farokhiani1؛ Mohammad Reza Cheraghi2؛ Mahsa Emadi1؛ Reza Kaboodkhani3؛ Ali Akbari1؛ Naeimehossadat Asmarian1؛ Mahsa Banifatemi1
1Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
3Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Effective pain management is crucial in septorhinoplasty and remains a significant challenge. This study investigated the effect of ketorolac and paracetamol on pain control in septorhinoplasty patients and assessed their efficacy in reducing the need for rescue analgesics.
Methods: This double-blind randomized clinical trial was conducted at Madar-Koodak Hospital (Shiraz, Iran), in 2022. Ninety-nine patients were randomly assigned to three groups to receive ketorolac 30 mg (n=33), paracetamol 1000 mg (n=33), and normal saline (n=33), respectively. All the medications  were administered intravenously (IV) 30 min before surgery. The randomization procedure followed the block randomization method. If the pain did not subside, patients were also given a single dose of pethidine hydrochloride (25 mg). Pain intensity was measured using visual analog scale (VAS) 1 hour and 6 hours after surgery. The data were analyzed using SPSS software, using paired t tests, ANOVA, and Chi square tests.
Results: One-hour post-surgery, VAS scores in the ketorolac and paracetamol groups were significantly lower than in the placebo group (P<0.001). The mean difference with 95% CI for ketorolac-placebo and paracetamol-placebo was -0.57 (-0.94, -0.21), and -0.79 (-1.12, -0.45), respectively. The ketorolac and paracetamol groups required significantly less pethidine hydrochloride 1 hour post-surgery than the placebo group (P<0.001). The VAS scores and requiring pethidine were not significantly different between the ketorolac and paracetamol groups.
Conclusion: After septorhinoplasty, the administration of 1000 mg of IV paracetamol demonstrated comparable efficacy in pain reduction to 30 mg of ketorolac. It suggested that paracetamol could serve as a viable alternative to ketorolac in preventing postoperative pain after septorhinoplasty, particularly in patients for whom non-steroidal anti-inflammatory (NSAID) drugs could not be a suitable choice.
Trial registration number: IRCT20180922041084N6
کلیدواژه‌ها
Acetaminophen؛ Rhinoplasty؛ Pain management؛ Analgesia
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مراجع
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