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Siahpour, Fouziyeh, Sadeghi, Hosein, Panahi kokhdan, Esmaeel, Khoshnoud, Mohammad. (1403). Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats. سامانه مدیریت نشریات علمی, 10(4), 323-332. doi: 10.30476/tips.2024.103997.1255
Fouziyeh Siahpour; Hosein Sadeghi; Esmaeel Panahi kokhdan; Mohammad Javad Khoshnoud. "Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats". سامانه مدیریت نشریات علمی, 10, 4, 1403, 323-332. doi: 10.30476/tips.2024.103997.1255
Siahpour, Fouziyeh, Sadeghi, Hosein, Panahi kokhdan, Esmaeel, Khoshnoud, Mohammad. (1403). 'Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats', سامانه مدیریت نشریات علمی, 10(4), pp. 323-332. doi: 10.30476/tips.2024.103997.1255
Siahpour, Fouziyeh, Sadeghi, Hosein, Panahi kokhdan, Esmaeel, Khoshnoud, Mohammad. Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats. سامانه مدیریت نشریات علمی, 1403; 10(4): 323-332. doi: 10.30476/tips.2024.103997.1255

Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats

Trends in Pharmaceutical Sciences
مقاله 6، دوره 10، شماره 4، اسفند 2024، صفحه 323-332    اصل مقاله (1.14 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2024.103997.1255
نویسندگان
Fouziyeh Siahpour1؛ Hosein Sadeghi2؛ Esmaeel Panahi kokhdan2؛ Mohammad Javad Khoshnoud* 1
1Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
چکیده
Paraquat, specifically concentrated in lung tissue, leads to lung damage through oxidative and inflammatory processes. Pulmonary fibrosis occurs due to inflammation and an imbalance in the antioxidant system. Drugs like sildenafil, which inhibits phosphodiesterase enzymes, are used to treat pulmonary arterial hypertension. Antioxidants such as vitamin E can restore the oxidant-antioxidant balance. This study aimed to evaluate the effects of sildenafil and vitamin E on paraquat-induced pulmonary fibrosis. Male Wistar rats were used in animal studies. Paraquat was administered orally (R1-1) at a single dose of 40 mg/kg to induce lung fibrosis. Three groups were studied: Sildenafil administered orally (10 mg/kg) for 14 days. Vitamin E administered orally (500 mg/kg) for 14 days. Simultaneous administration of vitamin E (500 mg/kg) and sildenafil (10 mg/kg) for 14 days. Biochemical and histopathological tests were performed and compared with a control group. Paraquat administration caused fibrosis and an oxidant-antioxidant imbalance in lung tissue. Treatment with sildenafil and vitamin E increased glutathione (total GSH) and superoxide dismutase (SOD) levels while decreasing malondialdehyde (MDA) and hydroxyproline (HYP) levels compared to the paraquat group. Tumor Necrosis Factor-α (TNF-α) showed no significant changes in the study group compared to the control group. Treatment with sildenafil and vitamin E improved the oxidant-antioxidant balance in lung tissue exposed to paraquat. Additionally, this study demonstrated significant antioxidant effects of sildenafil and vitamin E against paraquat-induced oxidative damage.

تازه های تحقیق

Mohammad Javad Khoshnoud (Google Scholar)

Hossein Sadeghi (Google Scholar)

کلیدواژه‌ها
Paraquat؛ Sildenafil؛ Vitamin E؛ Pulmonary Fibrosis
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