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Mohammadi, Hossein, Jamshidi, Shahriyar, Khajehpour, Hassan, Adibi, Iman, Rahimiforoushani, Abbas, Karimi, Shaghayegh, Dadashi Serej, Nasim, Riyahi Alam, Nader. (1403). Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study. سامانه مدیریت نشریات علمی, 14(6), 519-532. doi: 10.31661/jbpe.v0i0.2407-1789
Hossein Mohammadi; Shahriyar Jamshidi; Hassan Khajehpour; Iman Adibi; Abbas Rahimiforoushani; Shaghayegh Karimi; Nasim Dadashi Serej; Nader Riyahi Alam. "Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study". سامانه مدیریت نشریات علمی, 14, 6, 1403, 519-532. doi: 10.31661/jbpe.v0i0.2407-1789
Mohammadi, Hossein, Jamshidi, Shahriyar, Khajehpour, Hassan, Adibi, Iman, Rahimiforoushani, Abbas, Karimi, Shaghayegh, Dadashi Serej, Nasim, Riyahi Alam, Nader. (1403). 'Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study', سامانه مدیریت نشریات علمی, 14(6), pp. 519-532. doi: 10.31661/jbpe.v0i0.2407-1789
Mohammadi, Hossein, Jamshidi, Shahriyar, Khajehpour, Hassan, Adibi, Iman, Rahimiforoushani, Abbas, Karimi, Shaghayegh, Dadashi Serej, Nasim, Riyahi Alam, Nader. Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study. سامانه مدیریت نشریات علمی, 1403; 14(6): 519-532. doi: 10.31661/jbpe.v0i0.2407-1789

Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study

Journal of Biomedical Physics and Engineering
دوره 14، شماره 6، اسفند 2024، صفحه 519-532    اصل مقاله (1.95 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2407-1789
نویسندگان
Hossein Mohammadi1؛ Shahriyar Jamshidi1؛ Hassan Khajehpour2؛ Iman Adibi3، 4؛ Abbas Rahimiforoushani5؛ Shaghayegh Karimi6؛ Nasim Dadashi Serej* 1، 7؛ Nader Riyahi Alam* 6، 8، 9
1Department of Bioimaging, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran
2Multimodal Functional Imaging Lab, Department of Physics and PERFORM Centre, Concordia University, Montreal, Quebec, Canada
3Department of Neurology, School of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran
4Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran
6Department of Medical Physics & Biomedical Eng., School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
7School of Computing and Engineering, University of West London, UK
8Concordia University, PERFORM Center, School of Health, Montreal, Quebec, Canada
9Magnetic Resonance Imaging Lab, National Brain Mapping Laboratory (NBML), Tehran, Iran
چکیده
Background: Acquiring new knowledge necessitates alterations at the synaptic level within the brain. Glutamate, a pivotal neurotransmitter, plays a critical role in these processes, particularly in learning and memory formation. Although previous research has explored glutamate’s involvement in cognitive functions, a comprehensive understanding of its real-time dynamics remains elusive during memory tasks.
Objective: This study aimed to investigate glutamate modulation during memory tasks in the right Dorsolateral Prefrontal Cortex (DLPFC) and parieto-occipital regions using functional Magnetic Resonance Spectroscopy (fMRS).
Material and Methods: This experimental research applied fMRS acquisition concurrently with a modified Sternberg’s verbal working memory task for fourteen healthy right-handed participants (5 females, mean age=30.64±4.49). The glutamate/total-creatine (Glu/tCr) ratio was quantified by LCModel in the DLPFC and parieto-occipital voxels while applying the tissue corrections.
Results: The significantly higher Glu/tCr modulation was observed during the task with a trend of increased modulation with memory load in both the DLPFC (19.9% higher, P-value=0.018) and parieto-occipital (33% higher, P-value=0.046) regions compared to the rest. 
Conclusion: Our pioneering fMRS study has yielded groundbreaking insights into brain functions during S-term Memory (STM) and learning. This research provides valuable methodological advancements for investigating the metabolic functions of both healthy and disordered brains. Based on the findings, cognitive demands directly correlate with glutamate levels, highlighting the neurochemical underpinnings of cognitive processing. Additionally, the obtained results potentially challenge the traditional left-hemisphere-centric model of verbal working memory, leading to the deep vision of hemispheric contributions to cognitive functions.

تازه های تحقیق

Hossein Mohammadi (PubMed)

Nasim Dadashi Serej (Google Scholar)

Nader Riyahi Alam (Google Scholar)

کلیدواژه‌ها
Memory, Short-Term؛ Glutamatergic Agents؛ Magnetic Resonance Spectroscopy؛ Learning؛ Metabolic Brain Mapping
سایر فایل های مرتبط با مقاله
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