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Rezaei, Heresh, Heidari, Saeed, Ommati, Mohammad Mehdi, Taheri, Babak, Khodaei, Forouzan, Dehghani, Mohammad Ali, Rowhanirad, Ayeh, Veisi-Goshtasb, Azadeh, Honarpishefard, Zahra, Azarpira, Negar, Niknahad, Hossein, Heidari, Reza. (1403). The dipeptide carnosine alleviates acute pancreatitis in an experimental model. سامانه مدیریت نشریات علمی, 10(4), 285-298. doi: 10.30476/tips.2024.102615.1240
Heresh Rezaei; Saeed Heidari; Mohammad Mehdi Ommati; Babak Taheri; Forouzan Khodaei; Mohammad Ali Dehghani; Ayeh Rowhanirad; Azadeh Veisi-Goshtasb; Zahra Honarpishefard; Negar Azarpira; Hossein Niknahad; Reza Heidari. "The dipeptide carnosine alleviates acute pancreatitis in an experimental model". سامانه مدیریت نشریات علمی, 10, 4, 1403, 285-298. doi: 10.30476/tips.2024.102615.1240
Rezaei, Heresh, Heidari, Saeed, Ommati, Mohammad Mehdi, Taheri, Babak, Khodaei, Forouzan, Dehghani, Mohammad Ali, Rowhanirad, Ayeh, Veisi-Goshtasb, Azadeh, Honarpishefard, Zahra, Azarpira, Negar, Niknahad, Hossein, Heidari, Reza. (1403). 'The dipeptide carnosine alleviates acute pancreatitis in an experimental model', سامانه مدیریت نشریات علمی, 10(4), pp. 285-298. doi: 10.30476/tips.2024.102615.1240
Rezaei, Heresh, Heidari, Saeed, Ommati, Mohammad Mehdi, Taheri, Babak, Khodaei, Forouzan, Dehghani, Mohammad Ali, Rowhanirad, Ayeh, Veisi-Goshtasb, Azadeh, Honarpishefard, Zahra, Azarpira, Negar, Niknahad, Hossein, Heidari, Reza. The dipeptide carnosine alleviates acute pancreatitis in an experimental model. سامانه مدیریت نشریات علمی, 1403; 10(4): 285-298. doi: 10.30476/tips.2024.102615.1240

The dipeptide carnosine alleviates acute pancreatitis in an experimental model

Trends in Pharmaceutical Sciences
مقاله 3، دوره 10، شماره 4، اسفند 2024، صفحه 285-298    اصل مقاله (503.09 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2024.102615.1240
نویسندگان
Heresh Rezaei1، 2؛ Saeed Heidari1؛ Mohammad Mehdi Ommati1، 3؛ Babak Taheri1؛ Forouzan Khodaei1؛ Mohammad Ali Dehghani1؛ Ayeh Rowhanirad1؛ Azadeh Veisi-Goshtasb1؛ Zahra Honarpishefard1؛ Negar Azarpira4؛ Hossein Niknahad1، 2؛ Reza Heidari* 1
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. 3Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
4Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Acute pancreatitis (AP) is a severe inflammatory disorder with a significant risk of mortality. However, restricted pharmacological treatments are available against this complication. Carnosine is an endogenous dipeptide with various pharmacological effects, including antioxidative and anti-inflammatory properties. The current study was designed to evaluate the impact of carnosine in an experimental model of AP. For this purpose, mice received arginine (two 4 g/kg doses, one-hour intervals, i.p) to induce AP. Then, animals received carnosine (50, 250, and 500 mg/kg, i.p). Serum levels of amylase, lipase, and glucose were significantly increased (P<0.001) in the current AP model. Moreover, alterations in oxidative stress biomarkers in the pancreas, including ROS formation, decreased antioxidant capacity, lipid peroxidation, and glutathione depletion, were detected in the AP group (P<0.001). A significant increase in the pancreatic level of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) was also evident in the l-arginine-treated mice (P<0.001). The major pancreatic tissue histopathological changes in the current AP model were the infiltration of inflammatory cells to the pancreas tissue, fluid accumulation, and acinar cell vacuolization/necrosis (P<0.05). Carnosine significantly reduced serum biomarkers of pancreas injury, alleviated oxidative stress, decreased pro-inflammatory cytokine levels, and improved histopathological changes in the pancreas of mice with AP (P<0.001). These findings suggest that carnosine is a protective agent in pancreatitis, with its antioxidative and anti-inflammatory properties playing a pivotal role in its mechanisms of action. Further research is needed to confirm these protective effects in clinical studies and assess carnosine safety in AP.

تازه های تحقیق

Heresh Rezaei (Google Scholar)

Reza Heidari (Google Scholar)

کلیدواژه‌ها
Inflammation؛ Oxidative stress؛ Pancreas؛ Peptide؛ Pharmacotherapy
مراجع
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