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In Vitro Radiosensitizing Effects of Urtica Dioica Leaf Aqueous Extract on the Killing of U87MG Glioblastoma Cell Line | ||
| Journal of Biomedical Physics and Engineering | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 06 آبان 1403 اصل مقاله (931.92 K) | ||
| نوع مقاله: Original Research | ||
| شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2403-1739 | ||
| نویسندگان | ||
| Maryam Khorramizadeh* 1؛ Zaynab Kord2؛ Mina Cheshmberah3؛ Marzieh Anaam3؛ Aziz Kassani4؛ Behnaz Deihim5 | ||
| 1Department of Medical Physics, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran | ||
| 2Department of Anaesthesiology, School of Allied Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran | ||
| 3School of Medicine, Dezful University of Medical Sciences, Dezful, Iran | ||
| 4Department of Community Medicine, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran | ||
| 5Department of Bacteriology and Virology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran | ||
| چکیده | ||
| Background: Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. Despite advancements in radiotherapy, its effectiveness is limited due to challenges in delivering high doses without harming healthy tissues. Objective: The current study aimed to determine whether Urtica dioica extract could enhance the cytotoxic effects of radiation on U87MG glioma cells and explore the underlying mechanisms. Material and Methods: This in-vitro study was conducted on the U87MG glioma cell line and investigated the effects of Urtica dioica extract (at various concentrations) and irradiation (2 Gy) on cell viability, cell cycle distribution, and apoptosis. Results: Urtica dioica extract exhibited a concentration and time-dependent cytotoxic effect on U87MG cells. Notably, combining the extract with radiotherapy resulted in a significantly greater reduction in cell viability compared to either treatment alone. Cell cycle analysis revealed that the combination treatment induced G2/M phase arrest more effectively than either treatment alone. Additionally, Urtica dioica extract enhanced the pro-apoptotic effects of radiation, indicated by a significant increase in the late apoptotic cell population. Conclusion: This study demonstrates the radiosensitizing properties of Urtica dioica extract in U87MG glioma cells. The extract promotes cell cycle arrest and apoptosis, potentially leading to improved radiotherapy efficacy. These findings suggest Urtica dioica as a promising complementary therapy for GBM treatment. | ||
| کلیدواژه‌ها | ||
| Apoptosis؛ Cell Cycle Arrest؛ Glioblastoma Multiforme (GBM)؛ Radiosensitizer؛ Radiotherapy؛ Urtica Dioica Extract؛ U87MG Glioma Cells؛ Complementary Therapies | ||
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آمار تعداد مشاهده مقاله: 82 تعداد دریافت فایل اصل مقاله: 115 |
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