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Grevanny, Ranny, Suhartono, Antonius Winoto, Herlingga Rahmasari Amin, Almasyifa, Auerkari, Elza Ibrahim. (1403). Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review. سامانه مدیریت نشریات علمی, 49(11), 680-690. doi: 10.30476/ijms.2024.100801.3332
Ranny Grevanny; Antonius Winoto Suhartono; Almasyifa Herlingga Rahmasari Amin; Elza Ibrahim Auerkari. "Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review". سامانه مدیریت نشریات علمی, 49, 11, 1403, 680-690. doi: 10.30476/ijms.2024.100801.3332
Grevanny, Ranny, Suhartono, Antonius Winoto, Herlingga Rahmasari Amin, Almasyifa, Auerkari, Elza Ibrahim. (1403). 'Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review', سامانه مدیریت نشریات علمی, 49(11), pp. 680-690. doi: 10.30476/ijms.2024.100801.3332
Grevanny, Ranny, Suhartono, Antonius Winoto, Herlingga Rahmasari Amin, Almasyifa, Auerkari, Elza Ibrahim. Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review. سامانه مدیریت نشریات علمی, 1403; 49(11): 680-690. doi: 10.30476/ijms.2024.100801.3332

Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review

Iranian Journal of Medical Sciences
مقاله 1، دوره 49، شماره 11، بهمن 2024، صفحه 680-690    اصل مقاله (273.91 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2024.100801.3332
نویسندگان
Ranny Grevanny1؛ Antonius Winoto Suhartono2؛ Almasyifa Herlingga Rahmasari Amin2؛ Elza Ibrahim Auerkari* 2
1Pediatric Dentistry Residency Program, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia
2Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, University of Indonesia, Jakarta 10430, Indonesia
چکیده
Aggressive periodontitis is an inflammation of the periodontal tissue that usually affects adolescents and young adults aged <30 years, caused by attachment loss and fast bone degradation. The correlation between the epigenetic status and the initiation and progression of numerous acquired diseases was documented. Consequently, targeting epigenetic factors within periodontal tissues stands as an appealing prospect for both the diagnosis and treatment of periodontitis. In addition to the role of pathogenic bacteria and their products,  alterations in gene expression due to extrinsic and intrinsic factors can cause disturbances in the host’s immune response. Epigenetic changes, whether DNA methylation or microRNA (miRNA) dysregulation, can cause changes in gene expression in aggressive periodontitis and lead to more severe and rapid loss of the periodontal tissues. This study aimed to elucidate the relationships between oral hygiene, pathogenic bacteria, and genetics in periodontitis development to promote targeted prevention and treatment for enhanced oral health in individuals at risk of aggressive periodontitis. The method employed in this study entailed a comprehensive review and analysis of scholarly literature on the relationship between epigenetic mechanisms and the development of aggressive periodontitis. In conclusion, epigenetic regulation plays an important role in the pathogenesis of periodontitis through DNA methylation mechanisms that begin with Toll-like receptors (TLRs), cytokine signaling pathways, promoter genes, and progress to pro-inflammatory cells. When periodontal tissue inflammation occurs, miRNA inhibits protein translation from messenger ribonucleic acid (mRNA), which contributes to its aggressiveness.
کلیدواژه‌ها
Aggressive periodontitis؛ Epigenetics؛ DNA methylation؛ MicroRNAs
سایر فایل های مرتبط با مقاله
مراجع
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