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Navab, Rahul, Futela, Pragyat, Kumari, Verkha, Valecha, Jayesh, Bandhu Gupta, Ramansh, Jain, Rohit. (1403). Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment. سامانه مدیریت نشریات علمی, 50(1), 1-10. doi: 10.30476/ijms.2024.101739.3446
Rahul Navab; Pragyat Futela; Verkha Kumari; Jayesh Valecha; Ramansh Bandhu Gupta; Rohit Jain. "Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment". سامانه مدیریت نشریات علمی, 50, 1, 1403, 1-10. doi: 10.30476/ijms.2024.101739.3446
Navab, Rahul, Futela, Pragyat, Kumari, Verkha, Valecha, Jayesh, Bandhu Gupta, Ramansh, Jain, Rohit. (1403). 'Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment', سامانه مدیریت نشریات علمی, 50(1), pp. 1-10. doi: 10.30476/ijms.2024.101739.3446
Navab, Rahul, Futela, Pragyat, Kumari, Verkha, Valecha, Jayesh, Bandhu Gupta, Ramansh, Jain, Rohit. Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment. سامانه مدیریت نشریات علمی, 1403; 50(1): 1-10. doi: 10.30476/ijms.2024.101739.3446

Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment

Iranian Journal of Medical Sciences
مقاله 1، دوره 50، شماره 1، فروردین 2025، صفحه 1-10    اصل مقاله (1.28 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2024.101739.3446
نویسندگان
Rahul Navab1؛ Pragyat Futela* 2؛ Verkha Kumari3؛ Jayesh Valecha4؛ Ramansh Bandhu Gupta5؛ Rohit Jain6
1PES Institute of Medical Sciences and Research, Kuppam, India
2Mayo Clinic, Rochester, MN, United States of America
3Liaquat National Hospital & Medical College, Karachi, Pakistan
4Indira Gandhi Medical College and Hospital, Shimla, India
5University College of Medical Sciences, New Delhi, India
6Penn State Health Milton S. Hershey Medical Center, Pennsylvania, United States of America
چکیده
Multiple Myeloma (MM) is a hematologic malignancy characterized by clonal plasma cell development, leading to serious complications. Despite traditional treatments, MM remains incurable, necessitating innovative therapeutic approaches. Chimeric Antigen Receptor (CAR) T-cell therapy and Bispecific T-cell engagers (BiTEs) are emerging immunotherapies showing promise in MM treatment. CAR T-cell therapy involves modifying patient T-cells to target specific antigens, primarily B Cell Maturation Antigen (BCMA). BiTEs, on the other hand, are non-IgG-like bispecific antibodies designed to engage both CD3 and tumor-associated antigens. These therapies exhibit impressive efficacy in clinical trials, leading to FDA approvals for specific MM patient populations. Despite their successes, these therapies come with unique challenges and adverse effects, such as cytokine release syndrome (CRS) and neurotoxicity. This narrative review explores the mechanisms, efficacy, challenges, and potential benefits of CAR T-cell and BiTE therapies for MM patients, shedding light on their roles in addressing this complex disease.
کلیدواژه‌ها
Multiple myeloma؛ CAR T-cell therapy؛ Bispecific antibodies؛ Immunotherapy
سایر فایل های مرتبط با مقاله
مراجع
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