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Sadeghi Ataabadi, Mahmoud, Bahmanpour, Soghra, Yousefinejad, Saeed, Alaee, Sanaz, Arabnezhad, Mohammad Reza, Esmati Gharehchah, Roohollah. (1401). Androgens and COVID-19: A Double-Edged Sword. سامانه مدیریت نشریات علمی, 7(1), -. doi: 10.30476/jamsat.2023.95677.1038
Mahmoud Sadeghi Ataabadi; Soghra Bahmanpour; Saeed Yousefinejad; Sanaz Alaee; Mohammad Reza Arabnezhad; Roohollah Esmati Gharehchah. "Androgens and COVID-19: A Double-Edged Sword". سامانه مدیریت نشریات علمی, 7, 1, 1401, -. doi: 10.30476/jamsat.2023.95677.1038
Sadeghi Ataabadi, Mahmoud, Bahmanpour, Soghra, Yousefinejad, Saeed, Alaee, Sanaz, Arabnezhad, Mohammad Reza, Esmati Gharehchah, Roohollah. (1401). 'Androgens and COVID-19: A Double-Edged Sword', سامانه مدیریت نشریات علمی, 7(1), pp. -. doi: 10.30476/jamsat.2023.95677.1038
Sadeghi Ataabadi, Mahmoud, Bahmanpour, Soghra, Yousefinejad, Saeed, Alaee, Sanaz, Arabnezhad, Mohammad Reza, Esmati Gharehchah, Roohollah. Androgens and COVID-19: A Double-Edged Sword. سامانه مدیریت نشریات علمی, 1401; 7(1): -. doi: 10.30476/jamsat.2023.95677.1038

Androgens and COVID-19: A Double-Edged Sword

Journal of Advanced Medical Sciences and Applied Technologies
دوره 7، شماره 1، آذر 2022    اصل مقاله (474.55 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/jamsat.2023.95677.1038
نویسندگان
Mahmoud Sadeghi Ataabadi1؛ Soghra Bahmanpour2؛ Saeed Yousefinejad3؛ Sanaz Alaee* 1؛ Mohammad Reza Arabnezhad4؛ Roohollah Esmati Gharehchah5
1Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3Research Center for Health Sciences, Institute of Health, Department of Occupational Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman, University of Medical Sciences, Kerman, Iran
5Department of Nursing, Faculty of nursing and midwifery, Islamic Azad University of Bushehr, Bushehr, Iran
چکیده
The world is still affected by the major public health threat of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The evidence has shown that men are more likely to die from SARS-CoV-2 infection. Numerous studies are devoted to investigating the causes of this disparity, which seems to be multifactorial. The immune response can be affected by sex hormones, especially androgens. It has been revealed that SARS-CoV-2 targets the cells through ACE2 and TMPRSS2 receptors both of which are regulated by the androgen receptor. The relationship between these receptors and androgens may explain the difference in COVID-19 disease severity and mortality in different genders. On the other hand, it has also been found that severe testosterone and dihydrotestosterone deficiencies or low testosterone in critically ill male COVID-19 patients could be a prognostic marker of severe disease. Nonetheless, as a double-edged sword, androgens have positive effects on immunomodulation and immune protection, while causing negative effects as they facilitate the entrance of the virus into the cell. The present study is thus aimed to investigate the different aspects of the influence of androgens on COVID-19 development.
کلیدواژه‌ها
SARS-CoV-2؛ COVID-19؛ Androgens؛ Testosterone
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