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Najib, Fateme Sadat, Izanloo, Elham, Aghdaki, Maryam, Khansalar, Soolmaz, Fattahi, Mohammad Javad, Oveisi, Zahra, Haghshenas, Mohammad Reza. (1403). Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2024.101732.2042
Fateme Sadat Najib; Elham Izanloo; Maryam Aghdaki; Soolmaz Khansalar; Mohammad Javad Fattahi; Zahra Oveisi; Mohammad Reza Haghshenas. "Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer". سامانه مدیریت نشریات علمی, , , 1403, -. doi: 10.30476/mejc.2024.101732.2042
Najib, Fateme Sadat, Izanloo, Elham, Aghdaki, Maryam, Khansalar, Soolmaz, Fattahi, Mohammad Javad, Oveisi, Zahra, Haghshenas, Mohammad Reza. (1403). 'Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2024.101732.2042
Najib, Fateme Sadat, Izanloo, Elham, Aghdaki, Maryam, Khansalar, Soolmaz, Fattahi, Mohammad Javad, Oveisi, Zahra, Haghshenas, Mohammad Reza. Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer. سامانه مدیریت نشریات علمی, 1403; (): -. doi: 10.30476/mejc.2024.101732.2042

Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 مرداد 1403    اصل مقاله (455.62 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2024.101732.2042
نویسندگان
Fateme Sadat Najib1؛ Elham Izanloo2؛ Maryam Aghdaki2؛ Soolmaz Khansalar3؛ Mohammad Javad Fattahi3؛ Zahra Oveisi2؛ Mohammad Reza Haghshenas* 3
1Obstetrics and Gynecology Department, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Obstetrics and Gynecology Department, Shiraz University of Medical Sciences, Shiraz, Iran
3Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The gene's 3′ untranslated region of stromal cell-derived factor1 (SDF-1/ CXC chemokine ligand 12 (CXCL12)) contains a polymorphism, known as SDF1-3′A at location 801, and has been linked to various types of cancers. The present study aimed to evaluate the relationship between this polymorphism and genetic predisposition to endometrial cancer.
Method: In this case-control study, DNA was extracted from blood samples of 108 endometrial cancer patients and 123 healthy individuals through salting out method. Genotyping was done by restriction fragment length polymorphism-polymerase chain reaction method, and the data were analyzed using chi-square test.
Results: A total number of 67 (62%) patients emerged as GG genotypes, 35 (32.4%) with GA, and 6 (5.6%) with AA genotypes. The frequency of GG, GA and AA in healthy control group was found to be 68 (55.3%), 50 (40.6%) and 5 (4.1%), respectively. Furthermore, the most frequent allele in both patient (169 (78.25%)) and control (186 (75.6%)) groups was G allele. However, no significant difference was observed between genotypes and alleles frequencies between the two groups. Furthermore, no significant association was observed between genotypes distribution and menopausal status (P = 0.70), tumor size (P = 0.62), degree of tumor differentiation (P = 0.74), stage (P = 0.35), tumor type (P = 0.22), and myometrial invasion (P = 0.22).
Conclusion: Our results show that SDF1-3′A at location 801 may not enhance the risk of endometrial cancer. However, further research with a larger sample size is required to understand the molecular behavior of the SDF-1 gene polymorphism in endometrial cancer.

تازه های تحقیق

Fateme Sadat Najib (Google Scholar)

Mohammad Reza Haghshenas (Google Scholar)

کلیدواژه‌ها
Endometrial neoplasms؛ Stromal cell-derived factor1؛ Chemokine CXCL12؛ Genotype
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