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Abbasi, Samaneh, Khademi, Sara, Montazerabadi, Alireza, Sahebkar, Amirhossein. (1403). FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review. سامانه مدیریت نشریات علمی, 14(4), 323-334. doi: 10.31661/jbpe.v0i0.2404-1754
Samaneh Abbasi; Sara Khademi; Alireza Montazerabadi; Amirhossein Sahebkar. "FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review". سامانه مدیریت نشریات علمی, 14, 4, 1403, 323-334. doi: 10.31661/jbpe.v0i0.2404-1754
Abbasi, Samaneh, Khademi, Sara, Montazerabadi, Alireza, Sahebkar, Amirhossein. (1403). 'FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review', سامانه مدیریت نشریات علمی, 14(4), pp. 323-334. doi: 10.31661/jbpe.v0i0.2404-1754
Abbasi, Samaneh, Khademi, Sara, Montazerabadi, Alireza, Sahebkar, Amirhossein. FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review. سامانه مدیریت نشریات علمی, 1403; 14(4): 323-334. doi: 10.31661/jbpe.v0i0.2404-1754

FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review

Journal of Biomedical Physics and Engineering
دوره 14، شماره 4، مهر و آبان 2024، صفحه 323-334    اصل مقاله (1 M)
نوع مقاله: Systematic Review
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2404-1754
نویسندگان
Samaneh Abbasi1؛ Sara Khademi2؛ Alireza Montazerabadi* 1، 3؛ Amirhossein Sahebkar* 4، 5، 6
1Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
3Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
5Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Fibroblast Activation Protein (FAP)-targeted nanoparticles (NPs) are designed to accumulate in cancerous stroma. These NPs hold promise for imaging applications in cancer therapy.
Objective: This systematic review aimed to comprehensively explore the use of FAP-targeting NPs for cancer diagnosis through different imaging modalities.
Material and Methods: This systematic review followed the framework proposed by O’Malley and Arksey. Peer-reviewed studies were searched in the Scopus, Science Direct, PubMed, and Google Scholar databases. Eligible studies were selected, and data were extracted to investigate the FAP-targeting NPs in imaging. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was also utilized to present the results.
Results: Five studies met the specified inclusion criteria and were finally selected for analysis. The extracted data was classified into two categories: general and specific data. The general group indicated that most studies have been conducted in Mexico and have increased since 2022, and the specific group showed that colorectal cancer and Nude mice have received the most research attention. Furthermore, FAP-targeted NPs have demonstrated superior diagnostic imaging capabilities, even compared to specific methods for each cancer type. Also, they have been safe, with no toxicity. 
Conclusion: FAP-targeted NPs using different ligands, such as Fibroblast Activation Protein Inhibitor (FAPI), can accurately detect tumors and metastases, and outperform specific cancer peptides like PSMA in cancer diagnosis. They are also non-toxic and do not cause radiation damage to tissues. Therefore, FAP-targeted NPs have the potential to serve as a viable alternative to FAP-targeted radionuclides for cancer diagnosis.

تازه های تحقیق

Alireza Montazerabadi (Google Scholar)

Amirhossein Sahebkar (Google Scholar)

 

کلیدواژه‌ها
Neoplasms؛ Fibroblast Activation Protein (FAP)؛ Imaging؛ Nanoparticles (NPs)؛ Molecular Imaging
سایر فایل های مرتبط با مقاله
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