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Ekhtiyardar, Najmeh, Asadi Dolatabad, Fereshteh, Akbarizadeh, Amin Reza, Salek, Sanaz, Hajizadeh, Neda, Khoushnoud, Mohammad Javad, Mohammadi-Bardbori, Afshin. (1403). Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats. سامانه مدیریت نشریات علمی, 10(2), 113-120. doi: 10.30476/tips.2024.102397.1238
Najmeh Ekhtiyardar; Fereshteh Asadi Dolatabad; Amin Reza Akbarizadeh; Sanaz Salek; Neda Hajizadeh; Mohammad Javad Khoushnoud; Afshin Mohammadi-Bardbori. "Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats". سامانه مدیریت نشریات علمی, 10, 2, 1403, 113-120. doi: 10.30476/tips.2024.102397.1238
Ekhtiyardar, Najmeh, Asadi Dolatabad, Fereshteh, Akbarizadeh, Amin Reza, Salek, Sanaz, Hajizadeh, Neda, Khoushnoud, Mohammad Javad, Mohammadi-Bardbori, Afshin. (1403). 'Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats', سامانه مدیریت نشریات علمی, 10(2), pp. 113-120. doi: 10.30476/tips.2024.102397.1238
Ekhtiyardar, Najmeh, Asadi Dolatabad, Fereshteh, Akbarizadeh, Amin Reza, Salek, Sanaz, Hajizadeh, Neda, Khoushnoud, Mohammad Javad, Mohammadi-Bardbori, Afshin. Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats. سامانه مدیریت نشریات علمی, 1403; 10(2): 113-120. doi: 10.30476/tips.2024.102397.1238

Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats

Trends in Pharmaceutical Sciences
مقاله 3، دوره 10، شماره 2، شهریور 2024، صفحه 113-120    اصل مقاله (697.09 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2024.102397.1238
نویسندگان
Najmeh Ekhtiyardar1؛ Fereshteh Asadi Dolatabad1؛ Amin Reza Akbarizadeh1؛ Sanaz Salek2؛ Neda Hajizadeh1؛ Mohammad Javad Khoushnoud1؛ Afshin Mohammadi-Bardbori* 1
1Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
2Department of Microbiology, College of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
چکیده
Aryl hydrocarbon receptor (AHR) is a nuclear receptor that mediates responses to environmental stimuli. The microbiome, influenced by factors such as nutrition, antibiotics, stress, and infection, plays a crucial role in mood, cognition, and mental health through the gut-brain axis. Chronic stress, known to impact both mental and physical health, is associated with depression onset, with social defeat being a potent stressor. This study investigates the effects of endogenous AHR ligands on the microbiota-gut-brain axis and behavioral changes in rats subjected to chronic stress. Male rats were divided into six groups: control, social defeat (SD), treatment with endogenous AHR ligand 6-formylindole [3,2-b]carbazole (FICZ) ± SD and treatment with tryptophan (TRP) ± SD. AHR ligands were administered weekly for one month, and fecal samples were collected for microbial analysis. Forced swimming and splash tests were used to assess depression behaviors. The results showed FICZ positively impacting depression-like behaviors, while chronic stress and depression correlated with decreased Lactobacillus species frequency, especially in the social defeat group. Further investigations are warranted to explore the impact of social defeat stress on microbial populations across other groups and other bacterial species.

تازه های تحقیق

Afshin Mohammadi-Bardbori (Google Scholar)

کلیدواژه‌ها
AHR؛ 6-formylindole [3؛ 2-b]carbazole (FICZ)؛ Tryptophan؛ Microbiota-Gut-Brain-Axis؛ Social defeat؛ Depression
مراجع
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