Gaiday, Andrey, Tussupkaliyev, Akylbek, Nurken, Abay, Gaiday, Assel, Primbetova, Ainur, Dossimbetova, Moldir, Yeszhanova, Assemgul, Karimsakova, Bibigul, Ablakimova, Nurgul. (1403). Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report. سامانه مدیریت نشریات علمی, 49(7), 461-466. doi: 10.30476/ijms.2024.102119.3487
Andrey Gaiday; Akylbek Tussupkaliyev; Abay Nurken; Assel Gaiday; Ainur Primbetova; Moldir Dossimbetova; Assemgul Yeszhanova; Bibigul Karimsakova; Nurgul Ablakimova. "Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report". سامانه مدیریت نشریات علمی, 49, 7, 1403, 461-466. doi: 10.30476/ijms.2024.102119.3487
Gaiday, Andrey, Tussupkaliyev, Akylbek, Nurken, Abay, Gaiday, Assel, Primbetova, Ainur, Dossimbetova, Moldir, Yeszhanova, Assemgul, Karimsakova, Bibigul, Ablakimova, Nurgul. (1403). 'Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report', سامانه مدیریت نشریات علمی, 49(7), pp. 461-466. doi: 10.30476/ijms.2024.102119.3487
Gaiday, Andrey, Tussupkaliyev, Akylbek, Nurken, Abay, Gaiday, Assel, Primbetova, Ainur, Dossimbetova, Moldir, Yeszhanova, Assemgul, Karimsakova, Bibigul, Ablakimova, Nurgul. Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report. سامانه مدیریت نشریات علمی, 1403; 49(7): 461-466. doi: 10.30476/ijms.2024.102119.3487
Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report
1Department of Obstetrics and Gynecology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
2Department of Gynecology, Regional Perinatal Center, Aktobe, Kazakhstan
3Department of General Medical Practice, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
4Department of Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
5Department of Hospital Pharmacy, Regional Perinatal Center, Aktobe, Kazakhstan
چکیده
The incidence of ectopic pregnancy (EP) has increased in recent years, owing to causes such as pelvic inflammatory diseases and assisted reproductive technologies (ART). The present study reported a case of a 33-year-old nulliparous woman with a history of previous ectopic pregnancies, who underwent pelvic ultrasound in August 2022, which revealed a double EP including a cervical pregnancy and a tubal stump pregnancy. Despite known risk factors and elevated beta-human chorionic gonadotropin (β-hCG) levels, a conservative approach, utilizing multiple doses of systemic methotrexate (MTX) injections, was employed to preserve fertility at the Regional Perinatal Center in Aktobe, Kazakhstan. Treatment efficacy was monitored through β-hCG levels and ultrasound imaging, with successful resolution of both EPs and preservation of reproductive function. The present case highlighted the safety and efficacy of MTX therapy in managing complex EP presentations, emphasizing the necessity of individualized treatment approaches in reproductive medicine, particularly in terms of preserving fertility in patients undergoing ART. Multiple high doses of MTX injections were beneficial for pregnancy with two distinct regions, fetal cardiac activity, and elevated serum β-hCG level. Further research is required to explore optimal treatment strategies for EP, considering patient-specific factors and treatment goals.
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