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Outcome of Cyclophosphamide Treatment Following Hematopoietic Stem Cell Transplantation in a Thalassemia Patient: A Case Study | ||
| Iranian Journal of Immunology | ||
| دوره 21، شماره 2، شهریور 2024، صفحه 176-183 اصل مقاله (1.46 M) | ||
| نوع مقاله: Case Report | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2024.101584.2752 | ||
| نویسندگان | ||
| Heba M. Bahlol1، 2؛ Sohaila M. Khalil1، 2؛ Mohamed R. El-Shanshory2، 3؛ Mohamed L. Salem* 1، 2 | ||
| 1Immunology and Parasitology Division, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt. | ||
| 2Center of Excellence in Cancer Research, New Tanta University Teaching Hospital, Tanta University, Egypt. | ||
| 3Pediatric Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt. | ||
| چکیده | ||
| Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for β-thalassemia major in children. However, it often induces graft-versus-host-disease (GVHD), which is associated with complications. In the present study, we used cyclophosphamide (Cy) to treat a thalassemia patient post-HSCT to reduce the adverse effects of GVHD. We monitored the numbers and phenotype of granulocytes. In this case study, an 11-year-old female patient, diagnosed with β-thalassemia major (Pesaro class II), was treated with Cy before and after HSCT with mobilized CD34+ cells. Both the relative and absolute granulocyte counts, as well as CD33+CD11b+ cell counts, increased significantly after HSCT until day 56. However, they suddenly began to decrease after day 56, accompanied by severe diarrhea, skin rash, and a decrease in bilirubin levels compared to day -12. Furthermore, compared to day -12, IL-22 levels increased until day 56, and then decreased, while IDO levels continued to rise after day 56. Our data suggest the potential use of IL-22 and IDO as biomarkers for GVHD assessment. It also indicates that Cy promotes HSCT reconstitution by increasing CD33+CD11b+ cells, which may play a crucial role in reducing GVHD risks. However, further studies are needed to elucidate the mechanism behind GVHD recurrence. | ||
| کلیدواژه‌ها | ||
| B-thalassemia؛ Granulocytes؛ Cyclophosphamide؛ GVHD؛ HSCT | ||
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آمار تعداد مشاهده مقاله: 535 تعداد دریافت فایل اصل مقاله: 329 |
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