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The Protective Role of IL-17 and IL-22 in COVID-19 Infection | ||
| Iranian Journal of Immunology | ||
| دوره 21، شماره 3، آذر 2024، صفحه 225-233 اصل مقاله (733.56 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2024.100909.2721 | ||
| نویسندگان | ||
| Sengul Aksakal* 1؛ Selim Gorgun2 | ||
| 1Department of Immunology and Allergy, Samsun Training and Research Hospital, Samsun, Turkey. | ||
| 2Department of Microbiology and Clinical Microbiology, Samsun Training and Research Hospital, Samsun, Turkey. | ||
| چکیده | ||
| Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fatal. We hypothesize that this excessive cytokine production impairs mucosal healing. IL-17 and IL-22 are cytokines that play a key role in protecting and regenerating mucosal tissues. IL-17 and IL-22 support each other, and the imbalance between them plays a role in the pathogenesis of many rheumatologic diseases. Objective: To investigate whether COVID-19 severity is related to IL17, IL-22, and the IL-17/IL-22 ratio. Methods: The study was planned prospectively and included 69 patients with active COVID-19 infection. Three groups were created: patients with upper respiratory tract infection, pneumonia, and cytokine storm. Blood samples were taken from the patients upon their first admission and serum levels of IL-17 and IL-22 were measured using the enzyme-linked immunosorbent assay (ELISA). We assessed the relationship between IL17, IL22, IL17/ IL22 ratio, clinical and lung involvement by comparing them with the healthy group. Results: The levels of IL-17 were significantly higher in COVID-19 patients with upper respiratory tract infection compared to the control group (p=0.027). IL17/IL-22 ratio significantly increased in patients with cytokine storm compared to the healthy controls (p=0.027). Serum levels of IL-22 were negatively correlated with the CO-RADS score (r=-0.31, p=0.004), while IL-17/IL-22 ratio was positively correlated with the CO-RADS score (r=0.29, p=0.008). Conclusion: Levels of IL-17, IL-22, and IL-17/IL-22 may provide valuable insights into the progression of COVID-19. | ||
| کلیدواژه‌ها | ||
| COVID-19؛ Interleukin-17؛ Interleukin-22؛ IL-17/IL-22 ratio؛ Th17 | ||
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آمار تعداد مشاهده مقاله: 519 تعداد دریافت فایل اصل مقاله: 192 |
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