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Kouchek, Mehran, Taherpour, Niloufar, Farasat, Mahya, Miri, Mirmohammad, Salarian, Sara, Shojaei, Seyedpouzhia, Hassanpour, Rezvan, Amini, Hossein, Sistanizad, Mohammad. (1403). The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2024.99691.3182
Mehran Kouchek; Niloufar Taherpour; Mahya Farasat; Mirmohammad Miri; Sara Salarian; Seyedpouzhia Shojaei; Rezvan Hassanpour; Hossein Amini; Mohammad Sistanizad. "The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial". سامانه مدیریت نشریات علمی, , , 1403, -. doi: 10.30476/ijms.2024.99691.3182
Kouchek, Mehran, Taherpour, Niloufar, Farasat, Mahya, Miri, Mirmohammad, Salarian, Sara, Shojaei, Seyedpouzhia, Hassanpour, Rezvan, Amini, Hossein, Sistanizad, Mohammad. (1403). 'The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2024.99691.3182
Kouchek, Mehran, Taherpour, Niloufar, Farasat, Mahya, Miri, Mirmohammad, Salarian, Sara, Shojaei, Seyedpouzhia, Hassanpour, Rezvan, Amini, Hossein, Sistanizad, Mohammad. The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1403; (): -. doi: 10.30476/ijms.2024.99691.3182

The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 04 تیر 1403    اصل مقاله (942.03 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.99691.3182
نویسندگان
Mehran Kouchek1؛ Niloufar Taherpour2؛ Mahya Farasat3؛ Mirmohammad Miri1؛ Sara Salarian1؛ Seyedpouzhia Shojaei1؛ Rezvan Hassanpour3؛ Hossein Amini3؛ Mohammad Sistanizad* 2، 3
1Department of Critical Care Medicine, Emam Hossein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Multiple trauma can cause an increase in creatine phosphokinase (CPK) and subsequently rhabdomyolysis and acute kidney injury (AKI). This study was designed to evaluate the effect of vitamin D3 on the serum CPK level and the incidence of rhabdomyolysis-induced AKI in patients with multiple trauma.
Methods: Patients with serum CPK levels <1000 IU/L were followed as the control 1 group. Subjects with serum CPK levels ≥1000 IU/L were randomly allocated to the control 2 or intervention group at Imam Hossein Medical Center, Tehran, Iran in 2020. Patients in the intervention group received a single dose of vitamin D3 (300,000 units) on the recruitment day. The serum level of CPK was recorded every 3 days for 14 days. Parametric and non-parametric tests were used to compare the CPK values between groups.
Results: Forty-six patients, consisting of 16, 15, and 15 in control 1, control 2, and intervention arms of the study were recruited, respectively. Unlike control groups, the significant steadily decreasing trend was seen only in the intervention group (P<0.001). This significant decrease in the intervention arm was observed on days 5 to 7 (P=0.001) and on days 8 to 10 (P<0.001) compared to the baseline.
Patients in the intervention group had a lower number of AKI or need for dialysis (P=0.869 and P=0.670 for AKI and dialysis, respectively) than control group 2, although the differences were not significant. 
Conclusion: The current study revealed that vitamin D3, could prevent the increasing trend of CPK during the first days and accelerate the normalization of CPK in patients with elevated CPK due to multiple trauma.
Trial registration number: IRCT20120703010178N23.
کلیدواژه‌ها
Acute kidney injury؛ Multiple trauma؛ Rhabdomyolysis؛ Cholecalciferol؛ Creatine kinase
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