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Hadavi, Seyed Mohammad Reza, Panah, Ashkan, Shamohammadi, Sona, Kanaani Nejad, Fatemeh, Sahmeddini, Mohammad Ali, Asmarian, Naeimehossadat. (1403). The Prophylactic Effect of Acetaminophen and Caffeine on Post Dural Puncture Headache after Spinal Anesthesia for Cesarean Section: A Randomized Double-Blind Clinical Trial. سامانه مدیریت نشریات علمی, 49(9), 573-579. doi: 10.30476/ijms.2023.99577.3166
Seyed Mohammad Reza Hadavi; Ashkan Panah; Sona Shamohammadi; Fatemeh Kanaani Nejad; Mohammad Ali Sahmeddini; Naeimehossadat Asmarian. "The Prophylactic Effect of Acetaminophen and Caffeine on Post Dural Puncture Headache after Spinal Anesthesia for Cesarean Section: A Randomized Double-Blind Clinical Trial". سامانه مدیریت نشریات علمی, 49, 9, 1403, 573-579. doi: 10.30476/ijms.2023.99577.3166
Hadavi, Seyed Mohammad Reza, Panah, Ashkan, Shamohammadi, Sona, Kanaani Nejad, Fatemeh, Sahmeddini, Mohammad Ali, Asmarian, Naeimehossadat. (1403). 'The Prophylactic Effect of Acetaminophen and Caffeine on Post Dural Puncture Headache after Spinal Anesthesia for Cesarean Section: A Randomized Double-Blind Clinical Trial', سامانه مدیریت نشریات علمی, 49(9), pp. 573-579. doi: 10.30476/ijms.2023.99577.3166
Hadavi, Seyed Mohammad Reza, Panah, Ashkan, Shamohammadi, Sona, Kanaani Nejad, Fatemeh, Sahmeddini, Mohammad Ali, Asmarian, Naeimehossadat. The Prophylactic Effect of Acetaminophen and Caffeine on Post Dural Puncture Headache after Spinal Anesthesia for Cesarean Section: A Randomized Double-Blind Clinical Trial. سامانه مدیریت نشریات علمی, 1403; 49(9): 573-579. doi: 10.30476/ijms.2023.99577.3166

The Prophylactic Effect of Acetaminophen and Caffeine on Post Dural Puncture Headache after Spinal Anesthesia for Cesarean Section: A Randomized Double-Blind Clinical Trial

Iranian Journal of Medical Sciences
مقاله 4، دوره 49، شماره 9، آذر 2024، صفحه 573-579    اصل مقاله (697.57 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.99577.3166
نویسندگان
Seyed Mohammad Reza Hadavi1؛ Ashkan Panah* 1؛ Sona Shamohammadi2؛ Fatemeh Kanaani Nejad1؛ Mohammad Ali Sahmeddini1؛ Naeimehossadat Asmarian1
1Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Post-dural puncture headache (PDPH) is the most common complication following spinal anesthesia among parturients undergoing cesarean section surgery. The purpose of this study was to evaluate the effectiveness of acetaminophen and caffeine in preventing PDPH.
Methods: This double-blind, randomized clinical trial was conducted on 96 obstetric women, who were candidates for elective cesarean section. Following the randomization of participants into two groups, participants in the intervention group received tablets of acetaminophen (500 mg)+caffeine (65 mg), and participants in the control group received placebo tablets orally 2 hours before spinal anesthesia induction and then every 6 hours after surgery up to 24 hours. All parturients were evaluated for frequency and intensity of PDPH every 6 hours until 24 hours after surgery and then 48 and 72 hours after surgery. Overall satisfaction during the first 72 hours of postpartum was evaluated. The data were analyzed using SPSS software. P<0.05 was considered statistically significant.
Results: Participants in the intervention group were 70% less likely to experience PDPH after spinal anesthesia (OR=0.31 P=0.01, 95% CI [0.12-0.77]). They also experienced significantly milder headaches 18 hours, 48 hours, and 72 hours later. Participants in the intervention group reported higher levels of satisfaction at the end of the study (P=0.01). No side effects related to the intervention were reported.
Conclusion: Prophylactic administration of acetaminophen+
caffeine decreases 70% the risk of PDPH and significantly attenuates pain intensity in obstetric patients who underwent spinal anesthesia for cesarean section.
Trial registration number: IRCT20141009019470N98.
کلیدواژه‌ها
Acetaminophen؛ Caffeine؛ Post-dural puncture headache؛ Anesthesia, spinal
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مراجع
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