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Targeted immunotherapy approaches for intraductal papillary neoplasm of the bile duct | ||
Iranian Journal of Colorectal Research | ||
مقاله 4، دوره 12، شماره 2، شهریور 2024، صفحه 58-60 اصل مقاله (494.55 K) | ||
نوع مقاله: Editorial | ||
شناسه دیجیتال (DOI): 10.30476/acrr.2024.102421.1214 | ||
نویسندگان | ||
Bahareh Sadri1؛ Massoud Vosough* 2 | ||
1Department of Regenerative Medicine, Cell Science Research Center, Royan institute for stem cell biology and technology, ACECR, Tehran, Iran. | ||
2Department of Regenerative Medicine, Cell Science Research Center, Royan institute for stem cell biology and technology, Tehran, Iran | ||
چکیده | ||
Abstract: Intraductal papillary neoplasm of the bile duct (IPNB) is a complex biliary tract neoplasm. Its classifications based on distinct clinical, pathological, and radiological features and gene mutations, are of paramount importance. The classification of IPNB into Type 1 and Type 2 has proven essential, as these subtypes present notably different molecular alterations and clinical behaviors. Type 1 IPNBs are characterized by KRAS, GNAS and RNF43 mutations. While, Type 2 IPNBs demonstrate TP53, SMAD4, and KMT2C mutations. Recognition of the subclasses along with the genetic alterations enables early detection and advancement of personalized therapeutic methods. In addition, the identification of more involved signaling pathways and their crosstalk are indispensable for the advancement of novel therapeutic approaches including targeted immunotherapy and gene therapy. These tailored approaches hold the promise of improving patient outcomes, minimizing side effects, and offering a brighter future for those afflicted by this intricate biliary neoplasm.The precise classification of IPNB besides the accurate identification of mutations and molecular alteration in each subclassification lead to the development of more accurate and efficient diagnostic and therapeutic methods. | ||
کلیدواژهها | ||
Cholangiocarcinoma؛ Bile duct neoplasm؛ Papilloma؛ Intraductal | ||
مراجع | ||
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