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Abd-El-Fatah, Samaa Salah, Fathy, Maha A., Alabiad, Mohamed Ali, Aljafil, Raja, Gobran, Mai Ahmed, Ahmad, Enssaf A., Alsharidah, Ashwag S., Alorini, Mohammed, Alnasser, Sulaiman Mohammed, Awadh, Sara A., Morgan, Enas N.. (1403). The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors. سامانه مدیریت نشریات علمی, 49(12), 794-807. doi: 10.30476/ijms.2024.99442.3152
Samaa Salah Abd-El-Fatah; Maha A. Fathy; Mohamed Ali Alabiad; Raja Aljafil; Mai Ahmed Gobran; Enssaf A. Ahmad; Ashwag S. Alsharidah; Mohammed Alorini; Sulaiman Mohammed Alnasser; Sara A. Awadh; Enas N. Morgan. "The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors". سامانه مدیریت نشریات علمی, 49, 12, 1403, 794-807. doi: 10.30476/ijms.2024.99442.3152
Abd-El-Fatah, Samaa Salah, Fathy, Maha A., Alabiad, Mohamed Ali, Aljafil, Raja, Gobran, Mai Ahmed, Ahmad, Enssaf A., Alsharidah, Ashwag S., Alorini, Mohammed, Alnasser, Sulaiman Mohammed, Awadh, Sara A., Morgan, Enas N.. (1403). 'The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors', سامانه مدیریت نشریات علمی, 49(12), pp. 794-807. doi: 10.30476/ijms.2024.99442.3152
Abd-El-Fatah, Samaa Salah, Fathy, Maha A., Alabiad, Mohamed Ali, Aljafil, Raja, Gobran, Mai Ahmed, Ahmad, Enssaf A., Alsharidah, Ashwag S., Alorini, Mohammed, Alnasser, Sulaiman Mohammed, Awadh, Sara A., Morgan, Enas N.. The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors. سامانه مدیریت نشریات علمی, 1403; 49(12): 794-807. doi: 10.30476/ijms.2024.99442.3152

The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors

Iranian Journal of Medical Sciences
مقاله 6، دوره 49، شماره 12، اسفند 2024، صفحه 794-807    اصل مقاله (4.32 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.99442.3152
نویسندگان
Samaa Salah Abd-El-Fatah1؛ Maha A. Fathy2؛ Mohamed Ali Alabiad* 3؛ Raja Aljafil4؛ Mai Ahmed Gobran3؛ Enssaf A. Ahmad1؛ Ashwag S. Alsharidah5؛ Mohammed Alorini6؛ Sulaiman Mohammed Alnasser7؛ Sara A. Awadh8؛ Enas N. Morgan2، 9
1Department of Anatomy and Embryology, College of Medicine, Zagazig University, Al-Sharquia, Egypt
2Department of Medical Physiology, College of Medicine, Zagazig University, Al-Sharquia, Egypt
3Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of Pathology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
5Department of Physiology, College of Medicine, Qassim University, Buraidah, Saudi Arabia
6Department of Pathology, College of Medicine, Qassim University, Unaizah, Kingdom of Saudi Arabia
7Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, Saudi Arabia
8Department of Biochemistry, College of Science and Art, King Abdelaziz University, Jeddah, Kingdom of Saudi Arabia
9Department of Physical Therapy, College of Medical Rehabilitation, Qassim University, Buraidah, Saudi Arabia
چکیده
Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population. Adropin regulates endothelial function and may play a role in the pathogenesis of CVD. Angiotensin-converting enzyme inhibitor (ACEI) treatment was reported to have a protective effect on both renal and cardiovascular function. This study investigated whether adropin is associated with renal and cardiovascular outcomes after using ACEI treatment in CKD rats.  
Methods: In 2021, in Zagazig, Egypt, rats were assigned to: GI, control group (n=8); GII, CKD group (n=8), and GIII, CKD+captopril group (n=8), in which CKD rats received 100 mg/Kg/day captopril orally. Adropin levels, renal function, blood pressure, and various CVD risk factors were measured. Renal, cardiac, and aortic tissues were examined histologically and immunohistochemically to detect the expression of vascular endothelial growth factor receptor-2 (VEGFR-2). To analyze data, ANOVA and Pearson’s correlation tests were used (SPSS version 18, P<0.05 is significant).
Results: Adropin was significantly lower in GII than in GI and GIII (P<0.001). Adropin in GII and GIII was negatively correlated with atherogenic index (P=0.019 and P=0.001, respectively), atherogenic co-efficient (P=0.012 and P=0.013, respectively), troponin I (P=0.021 and P=0.043, respectively), and nitric oxide (P=0.025 and P=0.038, respectively). VEGFR-2 expression decreased in GII and was elevated in GIII (P<0.001).
Conclusion: Adropin levels were significantly correlated with most CVD risk factors in CKD and captopril-treated CKD rats, indicating a role for adropin in the pathogenesis of CVD in CKD. It also refers to its implication in the ameliorative effect of ACEI treatment, possibly by affecting VEGFR-2 and nitric oxide release.
کلیدواژه‌ها
Adropin؛ Renal insufficiency؛ Chronic kidney disease؛ Heart disease risk factors؛ Peptidyl-dipeptidase A
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