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Rafiepour, Payman, Mortazavi, Seyed Mohammad Javad, Sihver, Lembit. (1403). A Critical Look at Heavy Ion Beam Irradiation for Vaccine Development. سامانه مدیریت نشریات علمی, 14(3), 315-318. doi: 10.31661/jbpe.v0i0.2405-1765
Payman Rafiepour; Seyed Mohammad Javad Mortazavi; Lembit Sihver. "A Critical Look at Heavy Ion Beam Irradiation for Vaccine Development". سامانه مدیریت نشریات علمی, 14, 3, 1403, 315-318. doi: 10.31661/jbpe.v0i0.2405-1765
Rafiepour, Payman, Mortazavi, Seyed Mohammad Javad, Sihver, Lembit. (1403). 'A Critical Look at Heavy Ion Beam Irradiation for Vaccine Development', سامانه مدیریت نشریات علمی, 14(3), pp. 315-318. doi: 10.31661/jbpe.v0i0.2405-1765
Rafiepour, Payman, Mortazavi, Seyed Mohammad Javad, Sihver, Lembit. A Critical Look at Heavy Ion Beam Irradiation for Vaccine Development. سامانه مدیریت نشریات علمی, 1403; 14(3): 315-318. doi: 10.31661/jbpe.v0i0.2405-1765

A Critical Look at Heavy Ion Beam Irradiation for Vaccine Development

Journal of Biomedical Physics and Engineering
دوره 14، شماره 3، شهریور 2024، صفحه 315-318    اصل مقاله (661.76 K)
نوع مقاله: Commentary
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2405-1765
نویسندگان
Payman Rafiepour1؛ Seyed Mohammad Javad Mortazavi* 2، 3؛ Lembit Sihver* 4، 5، 6
1Department of Nuclear Engineering, School of Mechanical Engineering, Shiraz University, Shiraz, Iran
2Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Radiation Physics, Technische Universität Wien, Atominstitut, 1040 Vienna, Austria
5Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, ON, Canada
6Department of Physics, East Carolina University, Greenville, NC 27858, USA
چکیده
Recent studies offer valuable insights into viral inactivation for vaccine development. Schulze et al. have demonstrated the potential of heavy ion beam irradiation to create effective vaccines, which is particularly relevant in the context of airborne pandemics. Notably, the success in immunizing mice via intranasal administration with the inactivated influenza virus is encouraging, especially given the genetic similarities between influenza and SARS-CoV-2. However, the study raises important considerations. While heavy ion treatment shows advantages, there are concerns about viral inactivation completeness and the potential for surviving viruses, albeit at extremely low levels. Prolonged irradiation times and the risk of selective pressure leading to the evolution of resistant variants are highlighted. Biosafety concerns regarding accidental lab escape of resistant strains are crucial, emphasizing the need for caution during experiments. Moreover, limitations in Monte Carlo simulations of virus irradiation are discussed, pointing out the need for more comprehensive studies to assess the impact of secondary particles on virus inactivation under realistic irradiation conditions. Given these considerations, while the study presents a promising approach for vaccine development, further research is essential to address potential drawbacks and optimize the method for safe and effective application.

تازه های تحقیق

Seyed Mohammad Javad Mortazavi (Google Scholar)

Lembit Sihver (Google Scholar)

کلیدواژه‌ها
Heavy Ion Beam Irradiation؛ Vaccines؛ Viruses؛ Viral Inactivation
سایر فایل های مرتبط با مقاله
مراجع
  1. Schulze K, Weber U, Schuy C, Durante M, Guzmán CA. Influenza Virus Inactivated by Heavy Ion Beam Irradiation Stimulates Antigen-Specific Immune Responses. 2024;16(4):465. doi: 10.3390/pharmaceutics16040465. PubMed PMID: 38675126. PubMed PMCID: PMC11054185.
  2. Mehdizadeh AR, Bevelacqua JJ, Mortazavi SAR, Mortazavi SMJ. COVID-19: Introducing Low Dose Radiation as an Effective Treatment for Pneumonia that Shouldn’t Induce Selective Pressure and New Mutations. J Biomed Phys 2020;10(3):247-50. doi: 10.31661/jbpe.v0i0.2005-1114. PubMed PMID: 32637368. PubMed PMCID: PMC7321390.
  3. Harvey WT, Carabelli AM, Jackson B, Gupta RK, Thomson EC, Harrison EM, et al. SARS-CoV-2 variants, spike mutations and immune escape. Nat Rev Microbiol. 2021;19(7):409-24. doi: 10.1038/s41579-021-00573-0. PubMed PMID: 34075212. PubMed PMCID: PMC8167834.
  4. Janik E, Niemcewicz M, Podogrocki M, Majsterek I, Bijak M. The Emerging Concern and Interest SARS-CoV-2 Variants. 2021;10(6):633. doi: 10.3390/pathogens10060633. PubMed PMID: 34064143. PubMed PMCID: PMC8224338.
  5. Francis Z, Incerti S, Zein SA, Lampe N, Guzman CA, Durante M. Monte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development. Radiat Res. 2021;195(3):221-9. doi: 10.1667/RADE-20-00241.1. PubMed PMID: 33411888.
  6. Feng G, Liu L, Cui W, Wang F. Electron beam irradiation on novel coronavirus (COVID-19): A Monte-Carlo simulation. Chin Phys B. 2020;29(4):048703. doi: 10.1088/1674-1056/ab7dac. PubMed PMID: 34191933. PubMed PMCID: PMC7351116.
  7. Rafiepour P, Sina S, Mortazavi SMJ. Inactivation of SARS-CoV-2 by charged particles for Future Vaccine Production Applications: A Monte Carlo study. Radiat Phys Chem. 2022;198:110265. doi: 10.1016/j.radphyschem.2022.110265. PubMed PMID: 35663798. PubMed PMCID: PMC9142867.
  8. Villagomez-Bernabe B, Chan SW, Coulter JA, Roseman AM, Currell FJ. Fast Ion-Beam Inactivation of Viruses, Where Radiation Track Structure Meets RNA Structural Biology. Radiat Res. 2022;198(1):68-80. doi: 10.1667/RADE-21-00133.1. PubMed PMID: 35436347.
  9. Kyriakou I, Sakata D, Tran HN, Perrot Y, Shin WG, Lampe N, et al. Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level. Cancers (Basel). 2021;14(1):35. doi: 10.3390/cancers14010035. PubMed PMID: 35008196. PubMed PMCID: PMC8749997.
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