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Hu, Can, Zhang, Yizhi, Liu, Junjiang, You, Yanyan, Wu, Fanglong, Zhou, Hongmei. (1403). Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic. سامانه مدیریت نشریات علمی, 21(2), 103-120. doi: 10.22034/iji.2024.99943.2668
Can Hu; Yizhi Zhang; Junjiang Liu; Yanyan You; Fanglong Wu; Hongmei Zhou. "Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic". سامانه مدیریت نشریات علمی, 21, 2, 1403, 103-120. doi: 10.22034/iji.2024.99943.2668
Hu, Can, Zhang, Yizhi, Liu, Junjiang, You, Yanyan, Wu, Fanglong, Zhou, Hongmei. (1403). 'Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic', سامانه مدیریت نشریات علمی, 21(2), pp. 103-120. doi: 10.22034/iji.2024.99943.2668
Hu, Can, Zhang, Yizhi, Liu, Junjiang, You, Yanyan, Wu, Fanglong, Zhou, Hongmei. Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic. سامانه مدیریت نشریات علمی, 1403; 21(2): 103-120. doi: 10.22034/iji.2024.99943.2668

Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic

Iranian Journal of Immunology
دوره 21، شماره 2، شهریور 2024، صفحه 103-120    اصل مقاله (2.66 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22034/iji.2024.99943.2668
نویسندگان
Can Hu1؛ Yizhi Zhang1؛ Junjiang Liu1؛ Yanyan You2؛ Fanglong Wu* 1؛ Hongmei Zhou1
1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Frontier Innovation Center for Dental Medicine Plus, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
2Department of Traditional Chinese Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
چکیده
Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the public. It is increasingly being recognized as a viable option for treating various diseases with minimal side effects. Common avenues of this therapy include herbal medicine, acupuncture, physical exercise, aromatherapy, dietary therapy, and homeopathy etc. Macrophages are highly heterogeneous cells that play multiple regulatory roles. Practices such as herbal medicine, acupuncture, physical exercise, aromatherapy and dietary therapy exert curative effects by modulating the polarization status and the secretory phenotype of macrophages directly. Furthermore, herbal medicine, acupuncture, and physical exercise influence the crosstalk between macrophages and other types of cells, including cancer cells and T cells. Mechanistically, herbal medicine and acupuncture produce curative effects in diverse diseases, including inflammatory diseases and tumors, mainly by influencing the phosphorylation of signaling proteins in macrophages. Therefore, targeting macrophages offers theoretical support for advancing the scientific understanding of this therapy and aids in identifying potential therapeutic options. Hence, in this review, we systematically summarize the different regulations of macrophages in herbal medicine, acupuncture, physical exercise, aromatherapy, dietary therapy and homeopathy, and further highlight the therapeutic potential of targeting macrophages in complementary and alternative medicine.
کلیدواژه‌ها
Complementary Therapies؛ Inflammation؛ Macrophage؛ Tumor
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